Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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Displaying entries 251 - 275 of 6330 in total

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
							Clear
Clomipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of clomipramine.	Details
Clomipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of clomipramine.	Details
Doxepin	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of doxepin.	Details
Doxepin	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of doxepin.	Details
Doxepin	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of doxepin.	Details
Doxepin	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of doxepin.	Details
Imipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of imipramine.	Details
Imipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of imipramine.	Details
Imipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of imipramine.	Details
Imipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of imipramine.	Details
Trimipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.	Details
Trimipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.	Details
Trimipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.	Details
Trimipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with poor metabolism of trimipramine.	Details
Amitriptyline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with poor metabolism of amitriptyline.	Details
Amitriptyline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of amitriptyline.	Details
Clomipramine	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with poor metabolism of clomipramine.	Details
Clomipramine	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of clomipramine.	Details
Doxepin	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with poor metabolism of doxepin.	Details
Doxepin	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of doxepin.	Details
Imipramine	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with poor metabolism of imipramine.	Details
Imipramine	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of imipramine.	Details
Trimipramine	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with poor metabolism of trimipramine.	Details
Trimipramine	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Effect Directly Studied	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of trimipramine.	Details
Codeine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 results in non-functioning enzyme variant and may be associated with reduced drug mtabolism or reduced therapeutic response when treated with codeine.	Details

Displaying entries 251 - 275 of 6330 in total

Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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