| Venlafaxine | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*5 | Not Available | - Whole gene deletion, homozygote
| Effect Directly Studied | Patients with this genotype have reduced metabolism of venlafaxine. | Details |
| Venlafaxine | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of remission when using venlafaxine to treat major depressive disorder | Details |
| Venlafaxine | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have increased risk of adverse events with venlafaxine | Details |
| Bleomycin | Bleomycin hydrolase
Gene symbol: BLMH
UniProt: Q13867 | --- | (G;G) | | Effect Directly Studied | Patients with this genotype have reduced survival time and increased frequency of early relapse when using bleomycin to treat testicular cancer. | Details |
| Morphine | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;T) / (T;T) | | Effect Directly Studied | Patients with this genotype may have an increased analgesic response to morphine. | Details |
| Morphine | Mu-type opioid receptor
Gene symbol: OPRM1
UniProt: P35372 | --- | (A;A) | | Effect Directly Studied | Patients with this genotype may have an increased analgesic response to morphine. | Details |
| Zolmitriptan | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene symbol: GNB3
UniProt: P16520 | --- | (C;T) / (T;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of responding to zolmitriptan when treating (condition: cluster headache). | Details |
| Gefitinib | ATP-binding cassette sub-family G member 2
Gene symbol: ABCG2
UniProt: Q9UNQ0 | --- | (A;C) | | ADR Directly Studied | Patients with this genotype have an increased risk of diarrhea with gefitinib. | Details |
| Gefitinib | Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533 | L858R | (G;G) / (G;T) | | Effect Directly Studied | The presence of this polymorphism in EGFR is associated with a higher response rate to gefitinib. | Details |
| Gefitinib | Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533 | G719A/C | (A;A) / (A;G) / (C;C) / (C;G) / (G;T) / (T;T) | | Effect Directly Studied | The presence of this polymorphism in EGFR is associated with a higher response rate to gefitinib. | Details |
| Gefitinib | Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533 | L861Q | (A;A) / (A;T) / (G;G) / (G;T) | | Effect Directly Studied | The presence of this polymorphism in EGFR is associated with a higher response rate to gefitinib. | Details |
| Codeine | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of codeine. | Details |
| Codeine | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*6 | (-;-) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of codeine. | Details |
| Codeine | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*5 | Not Available | - Whole gene deletion, homozygote
| Effect Directly Studied | Patients with this genotype have reduced metabolism of codeine. | Details |
| Amitriptyline | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of amitriptyline. | Details |
| Amitriptyline | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of remission when using amitriptyline to treat major depressive disorder | Details |
| Amitriptyline | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*2 | (A;A) / (A;G) | | Directly Studied Effect | Patients with this genotype have reduced metabolism of amitriptyline. | Details |
| Amitriptyline | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have increased risk of adverse events with amitriptyline | Details |
| Olanzapine | 5-hydroxytryptamine receptor 1A
Gene symbol: HTR1A
UniProt: P08908 | --- | (C;C) | - CC Allele (homozygous) (rs6295)
| Effect Directly Studied | The presence of this polymorphism in HTR1A may indicate a higher level of efficacy in improving negative symptoms of schizophrenia when treated with olanzapine. | Details |
| Atenolol | Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588 | --- | (C;C) / (C;G) | | Effect Directly Studied | Patients with this genotype have a greater reduction in blood pressure with atenolol. | Details |
| Omeprazole | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*2 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of omeprazole. | Details |
| Omeprazole | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*3 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of omeprazole. | Details |
| Diltiazem | Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588 | --- | (C;G) / (G;G) | | Effect Directly Studied | Patients with this genotype require a lower dosage of diltiazem to achieve a favourable rate-control response when treating atrial fibrillation. | Details |
| Clobazam | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*2 | (A;A) / (A;G) | | ADR Directly Studied | Patients with this genotype have reduced metabolism of clobazam. | Details |
| Clozapine | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene symbol: GNB3
UniProt: P16520 | --- | (T;T) | | ADR Directly Studied | Patients with this genotype have increased weight gain with clozapine. | Details |