Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

Documentation Pharmaco-genomics Pharmaco-metabolomics Pharmaco-transcriptomics Pharmaco-proteomics Search

Displaying entries 6326 - 6330 of 6330 in total

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
							Clear
Methadone	Cytochrome P450 2B6 Gene symbol: CYP2B6 UniProt: P20813	CYP2B6 3′UTR	Not Available	c.*1355A > G (rs707265)	pgx review	The presence of the rs707265 allele (CYP2B6 c.*1355A>G) has been shown increase the [(S)-MTD/MTD Dose] plasma ratio, and reduce clearance of (S)-methadone.	Details
Methadone	Cytochrome P450 2B6 Gene symbol: CYP2B6 UniProt: P20813	CYP2B6 3′UTR	Not Available	c.*1277A > T (rs1038376)	pgx review	The presence of the rs1038376 allele (CYP2B6 c.*1277A > T) has been shown to increase the [(S)-MTD/MTD Dose] plasma ratio and reduce (S)-MTD clearance.	Details
Methadone	Cytochrome P450 2B6 Gene symbol: CYP2B6 UniProt: P20813	CYP2B6 intron 1	Not Available	c.172–468 T > G (rs10403955)	pgx review	The presence of the rsl0403955 allele (c.172–468 T>G) has been shown increase the [(S)-MTD/MTD Dose] plasma ratio, and reduce clearance of (S)-methadone.	Details
Methadone	Cytochrome P450 2B6 Gene symbol: CYP2B6 UniProt: P20813	CYP2B6 intron 5	Not Available	c.923–197T > C (rs2279345)		The presence of the rs2279345 allele (CYP2B6 c.923–197T>C) has been shown increase the [(S)-MTD/MTD Dose] plasma ratio, and reduce clearance of (S)-methadone.	Details
Methadone	Cytochrome P450 3A4 Gene symbol: CYP3A4 UniProt: P08684	CYP3A4*1B	Not Available	−392A > G (rs2740574)	pgx review	The presence of the rs2740574 allele (CYP3A4 −392A>G) has been shown to increase (S)-methadone plasma levels.	Details

Displaying entries 6326 - 6330 of 6330 in total