| Amlodipine | Natriuretic peptides A
Gene symbol: NPPA
UniProt: P01160 | --- | (A;A) | | Effect Directly Studied | Patients with this genotype have increased risk of adverse cardiovascular outcomes with diuretics. | Details |
| Gemcitabine | Ribonucleoside-diphosphate reductase large subunit
Gene symbol: RRM1
UniProt: P23921 | --- | (A;A) | | ADR Directly Studied | Patients with this genotype have increased risk of neutropenia and neurotoxicity with gemcitabine. | Details |
| Lansoprazole | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*2 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of lansoprazole. | Details |
| Lansoprazole | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*3 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of lansoprazole. | Details |
| Lansoprazole | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;T) | | Effect Directly Studied | Patients with this genotype have increased plasma concentration of lansoprazole. | Details |
| Imipramine | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of imipramine. | Details |
| Celecoxib | Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712 | CYP2C9*3 | (A;C) / (C;C) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of celecoxib. | Details |
| Dextromethorphan | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of dextromethorphan. | Details |
| Dextromethorphan | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*6 | (-;-) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of dextromethorphan. | Details |
| Cisplatin | Glutathione S-transferase Mu 1
Gene symbol: GSTM1
UniProt: P09488 | GSTM1 | Not Available | - presence of functional GSTM1
| ADR Directly Studied | Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin]. | Details |
| Cisplatin | Low-density lipoprotein receptor-related protein 2
Gene symbol: LRP2
UniProt: P98164 | --- | (A;A) / (A;G) | Not Available | ADR Directly Studied | Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin]. | Details |
| Cisplatin | Glutathione S-transferase P
Gene symbol: GSTP1
UniProt: P09211 | --- | (A;G) / (G;G) | Not Available | ADR Directly Studied | Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin]. | Details |
| Cisplatin | DNA repair protein complementing XP-C cells
Gene symbol: XPC
UniProt: Q01831 | --- | (C;C) | Not Available | ADR Directly Studied | Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin]. | Details |
| Erlotinib | Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533 | G719A/C | (A;A) / (A;G) / (C;C) / (C;G) / (G;T) / (T;T) | | Effect Directly Studied | The presence of this polymorphism in EGFR is associated with a higher response rate to erlotinib. | Details |
| Erlotinib | Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533 | L861Q | (A;A) / (A;T) / (G;G) / (G;T) | | Effect Directly Studied | The presence of this polymorphism in EGFR is associated with a higher response rate to erlotinib. | Details |
| Erlotinib | Epidermal growth factor receptor
Gene symbol: EGFR
UniProt: P00533 | L858R | (G;G) / (G;T) | | Effect Directly Studied | The presence of this polymorphism in EGFR is associated with a higher response rate to erlotinib. | Details |
| Cyclophosphamide | Cytochrome P450 3A4
Gene symbol: CYP3A4
UniProt: P08684 | CYP3A4*1B | (A;G) / (G;G) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of cyclophosphamide to its active form and reduced disease free survival time when using cyclophosphamide to treat node-positive breast cancer. | Details |
| Cyclophosphamide | Cytochrome P450 2B6
Gene symbol: CYP2B6
UniProt: P20813 | CYP2B6*1G | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of cyclophosphamide to its active form. | Details |
| Mephenytoin | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*3 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of mephenytoin. | Details |
| Mephenytoin | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*8 | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of mephenytoin. | Details |
| Mephenytoin | Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261 | CYP2C19*7 | (A;A) / (A;T) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of mephenytoin. | Details |
| Nortriptyline | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of nortriptyline. | Details |
| Fluorouracil | Thymidylate synthase
Gene symbol: TYMS
UniProt: P04818 | TSER*2 | Not Available | | ADR Directly Studied | Patients with this genotype have increased risk of severe neutropenia or severe diarrhea with [drug; fluorouracil]. | Details |
| Fluorouracil | Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882 | --- | (A;G) / (G;G) | | ADR Directly Studied | Patients with this genotype have reduced metabolism of fluorouracil and increased risk of toxicity. | Details |
| Fluorouracil | Glutathione S-transferase P
Gene symbol: GSTP1
UniProt: P09211 | --- | (A;A) / (A;G) | | ADR Directly Studied | Patients with this genotype have increased risk of toxicity with fluorouracil | Details |