| Fluorouracil | Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882 | --- | (A;A) / (A;G) | | ADR Directly Studied | Patients with this genotype have reduced metabolism of fluorouracil and increased risk of toxicity. | Details |
| Fluorouracil | Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882 | --- | (A;A) / (A;T) | | ADR Directly Studied | Patients with this genotype have reduced metabolism of fluorouracil and increased risk of toxicity. | Details |
| Methotrexate | Canalicular multispecific organic anion transporter 1
Gene symbol: ABCC2
UniProt: Q92887 | ABCC2 IVS 23+56 | (C;C) / (C;T) | | ADR Directly Studied | Patients with this genotype have increased risk of toxicity with methotrexate. | Details |
| Methotrexate | Methylenetetrahydrofolate reductase
Gene symbol: MTHFR
UniProt: P42898 | --- | (C;T) / (T;T) | | ADR Directly Studied | Patients with this genotype have increased risk of toxicity with methotrexate. | Details |
| Carbamazepine | Heat shock 70 kDa protein 1-like
Gene symbol: HSPA1L
UniProt: P34931 | --- | (C;T) / (T;T) | | ADR Directly Studied | Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine. | Details |
| Carbamazepine | Heat shock 70 kDa protein 1A/1B
Gene symbol: HSPA1A
UniProt: P08107 | --- | (C;C) / (C;G) / (C;T) | | ADR Directly Studied | Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine. | Details |
| Carbamazepine | HLA class I histocompatibility antigen, B-15 alpha chain
Gene symbol: HLA-B
UniProt: P30464 | --- | (G;T) / (T;T) | | ADR Directly Studied | Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine. | Details |
| Carbamazepine | HLA class I histocompatibility antigen, A-31 alpha chain
Gene symbol: HLA-A
UniProt: P16189 | --- | (C;G) / (G;G) | | ADR Directly Studied | Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine. | Details |
| Carbamazepine | Promotilin
Gene symbol: MLN
UniProt: P12872 | --- | (A;A) / (A;C) | | ADR Directly Studied | Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine. | Details |
| Carbamazepine | Sodium channel protein type 1 subunit alpha
Gene symbol: SCN1A
UniProt: P35498 | --- | (A;A) / (A;G) | | Effect Directly Studied | Patients with this genotype have increased resistance to the anti-epileptic effects of carbamazepine. | Details |
| Carbamazepine | Flotillin-1
Gene symbol: FLOT1
UniProt: O75955 | HLA-B*1502 | (C;G) / (G;G) | | ADR Directly Studied | Taiwanese, Chinese, Indians, and Chinese–American patients with this genotype have increased risk of Stevens-Johnson syndrome or toxic epidermal necrolysis with carbamazepine. | Details |
| Carbamazepine | Mucin-21
Gene symbol: MUC21
UniProt: Q5SSG8 | HLA-B*1502 | (A;G) / (G;G) | | ADR Directly Studied | Taiwanese, Chinese, Indians, and Chinese–American patients with this genotype have increased risk of Stevens-Johnson syndrome or toxic epidermal necrolysis with carbamazepine. | Details |
| Simvastatin | Kinesin-like protein KIF6
Gene symbol: KIF6
UniProt: Q6ZMV9 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have a greater reduction in risk of a major cardiovascular event with high dose simvastatin. | Details |
| Simvastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene symbol: HMGCR
UniProt: P04035 | --- | (A;T) | | Effect Directly Studied | Patients with this genotype have a lesser reduction in LDL cholesterol with simvastatin. | Details |
| Verapamil | Beta-1 adrenergic receptor
Gene symbol: ADRB1
UniProt: P08588 | --- | (C;G) / (G;G) | | Effect Directly Studied | Patients with this genotype require a lower dosage of verapamil to achieve a favourable rate-control response when treating atrial fibrillation. | Details |
| Sumatriptan | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene symbol: GNB3
UniProt: P16520 | --- | (C;T) / (T;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of responding to sumatriptan when treating (condition: cluster headache). | Details |
| Tamoxifen | Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of tamoxifen resulting in reduced plasma concentrations its active form endoxifen. | Details |
| Tamoxifen | Coagulation factor V
Gene symbol: F5
UniProt: P12259 | --- | (A;A) / (A;G) | | ADR Directly Studied | Patients with this genotype have increased risk of a thromboembolic event with tamoxifen. | Details |
| Warfarin | Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712 | CYP2C9*2 | (C;T) / (T;T) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of warfarin. | Details |
| Daunorubicin | Cytochrome P450 1B1
Gene symbol: CYP1B1
UniProt: Q16678 | --- | (C;G) / (G;G) | | ADR Directly Studied | The presence of this genotype in CYP1B1 may be associated with an increased risk of drug-induced cytotoxicity from daunorubicin therapy. | Details |
| Daunorubicin | Heterogeneous nuclear ribonucleoprotein D0
Gene symbol: HNRNPD
UniProt: Q14103 | --- | (A;A) / (A;G) | | ADR Directly Studied | The presence of this genotype in HNRNPD may be associated with an increased risk of drug-induced cytotoxicity from daunorubicin therapy. | Details |
| Daunorubicin | SEC14-like protein 3
Gene symbol: SEC14L3
UniProt: Q9UDX4 | --- | (G;T) / (T;T) | | ADR Directly Studied | The presence of this genotype in SEC14L3 may be associated with an increased risk of drug-induced cytotoxicity from daunorubicin therapy. | Details |
| Daunorubicin | Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Gene symbol: IKBKE
UniProt: Q14164 | --- | (A;A) / (A;G) | | ADR Directly Studied | The presence of this genotype in IKBKE may be associated with an increased risk of drug-induced cytotoxicity from daunorubicin therapy. | Details |
| Naltrexone | Mu-type opioid receptor
Gene symbol: OPRM1
UniProt: P35372 | --- | (A;G) / (G;G) | | Effect Directly Studied | Patients with this genotype have an increased number of abstinent days when using naltrexone to treat alcohol addiction. | Details |
| Paroxetine | Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of remission when using paroxetine to treat major depressive disorder. | Details |