ABC multidrug transporter MDR2

Details

Name
ABC multidrug transporter MDR2
Synonyms
  • Multidrug resistance protein 2
Gene Name
MDR2
Organism
Trichophyton interdigitale (strain MR816)
Amino acid sequence
>lcl|BSEQ0052180|ABC multidrug transporter MDR2
MVEVSEKPNTQDDGVSKQENRNPASSSSSTSDKEKVAKKGNSDATKSSTPEDLDAQLAHL
PEHEREILKQQLFIPDAKATYGTLFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSL
AGTFRDIALHRITYDEFNSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAK
YLHAILRQNIGFFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVR
YWKLALICSSTIVAMILVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQ
EKLARQYEVHLKEARKWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSA
IVNILLAIVIGSFSIGNVAPNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEG
TIEFRGIKHIYPSRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGS
VLLDGRDIKTLNLRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIV
SAAKEANAHDFIMGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSAL
DTKSEGVVQAALDAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGT
YLQLVEAQKINEERGEESEDEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDT
KKSLSSVILSQKRSQEKETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSV
FFAKGITTLSLPPSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRAR
SKSFRAMLRQDIAFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTV
ALAFGWKLALVCISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVAS
LTREQGVMEIYEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEY
NAFQFFLCISCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESPDGEKLE
TVEGTIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDT
LSGGVYIDGKDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAAC
KAANIYDFIMSLPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSE
SEKVVQAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYE
LVHMQSLEKTQ
Number of residues
1331
Molecular Weight
145278.17
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / ATPase activity / ATPase-coupled transmembrane transporter activity
Components
integral component of membrane / plasma membrane
General Function
Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including terbinafine, 4-nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). May play a role in pathogenicity (PubMed:19141731).
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
93-113 147-167 219-239 242-262 325-345 358-378 762-782 810-830 884-904 910-930 995-1015 1025-1045
Cellular Location
Cell membrane
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDA0A059JJ46
UniProtKB Entry NameMDR2_TRIIM
General References
  1. Persinoti GF, Martinez DA, Li W, Dogen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioglu-Polat S, Ilkit M, Graser Y, Martinez-Rossi NM, White TC, Heitman J, Cuomo CA: Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. Genetics. 2018 Apr;208(4):1657-1669. doi: 10.1534/genetics.117.300573. Epub 2018 Feb 21. [Article]
  2. Fachin AL, Ferreira-Nozawa MS, Maccheroni W Jr, Martinez-Rossi NM: Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum. J Med Microbiol. 2006 Aug;55(Pt 8):1093-9. doi: 10.1099/jmm.0.46522-0. [Article]
  3. Paiao FG, Segato F, Cursino-Santos JR, Peres NT, Martinez-Rossi NM: Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs. FEMS Microbiol Lett. 2007 Jun;271(2):180-6. doi: 10.1111/j.1574-6968.2007.00710.x. Epub 2007 Apr 10. [Article]
  4. Maranhao FC, Paiao FG, Fachin AL, Martinez-Rossi NM: Membrane transporter proteins are involved in Trichophyton rubrum pathogenesis. J Med Microbiol. 2009 Feb;58(Pt 2):163-8. doi: 10.1099/jmm.0.002907-0. [Article]
  5. Martins MP, Franceschini ACC, Jacob TR, Rossi A, Martinez-Rossi NM: Compensatory expression of multidrug-resistance genes encoding ABC transporters in dermatophytes. J Med Microbiol. 2016 Jul;65(7):605-610. doi: 10.1099/jmm.0.000268. Epub 2016 Apr 26. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownsubstrateDetails