Pyruvate carboxylase
Details
- Name
- Pyruvate carboxylase
- Synonyms
- 6.4.1.1
- Gene Name
- pycA
- Organism
- Staphylococcus aureus (strain Mu50 / ATCC 700699)
- Amino acid sequence
>lcl|BSEQ0007588|Pyruvate carboxylase MKQIKKLLVANRGEIAIRIFRAAAELDISTVAIYSNEDKSSLHRYKADESYLVGSDLGPA ESYLNIERIIDVAKQANVDAIHPGYGFLSENEQFARRCAEEGIKFIGPHLEHLDMFGDKV KARTTAIKADLPVIPGTDGPIKSYELAKEFAEEAGFPLMIKATSGGGGKGMRIVREESEL EDAFHRAKSEAEKSFGNSEVYIERYIDNPKHIEVQVIGDEHGNIVHLFERDCSVQRRHQK VVEVAPSVGLSPTLRQRICDAAIQLMENIKYVNAGTVEFLVSGDEFFFIEVNPRVQVEHT ITEMVTGIDIVKTQILVAAGADLFGEEINMPQQKDITTLGYAIQCRITTEDPLNDFMPDT GTIIAYRSSGGFGVRLDAGDGFQGAEISPYYDSLLVKLSTHAISFKQAEEKMVRSLREMR IRGVKTNIPFLINVMKNKKFTSGDYTTKFIEETPELFDIQPSLDRGTKTLEYIGNVTING FPNVEKRPKPDYELASIPTVSSSKIASFSGTKQLLDEVGPKGVAEWVKKQDDVLLTDTTF RDAHQSLLATRVRTKDMINIASKTADVFKDGFSLEMWGGATFDVAYNFLKENPWERLERL RKAIPNVLFQMLLRASNAVGYKNYPDNVIHKFVQESAKAGIDVFRIFDSLNWVDQMKVAN EAVQEAGKISEGTICYTGDILNPERSNIYTLEYYVKLAKELEREGFHILAIKDMAGLLKP KAAYELIGELKSAVDLPIHLHTHDTSGNGLLTYKQAIDAGVDIIDTAVASMSGLTSQPSA NSLYYALNGFPRHLRTDIEGMESLSHYWSTVRTYYSDFESDIKSPNTEIYQHEMPGGQYS NLSQQAKSLGLGERFDEVKDMYRRVNFLFGDIVKVTPSSKVVGDMALYMVQNDLDEQSVI TDGYKLDFPESVVSFFKGEIGQPVNGFNKDLQAVILKGQEALTARPGEYLEPVDFEKVRE LLEEEQQGPVTEQDIISYVLYPKVYEQYIQTRNQYGNLSLLDTPTFFFGMRNGETVEIEI DKGKRLIIKLETISEPDENGNRTIYYAMNGQARRIYIKDENVHTNANVKPKADKSNPSHI GAQMPGSVTEVKVSVGETVKANQPLLITEAMKMETTIQAPFDGVIKQVTVNNGDTIATGD LLIEIEKATD
- Number of residues
- 1150
- Molecular Weight
- 128556.785
- Theoretical pI
- 4.93
- GO Classification
- FunctionsATP binding / biotin binding / biotin carboxylase activity / metal ion binding / pyruvate carboxylase activityProcessesgluconeogenesis / pyruvate metabolic process
- General Function
- Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0049967|Pyruvate carboxylase (pycA) TTGAAACAAATAAAAAAGTTACTTGTTGCTAACCGTGGAGAAATTGCAATTCGTATATTC AGAGCGGCGGCAGAATTAGACATCAGCACAGTTGCAATTTATTCGAATGAAGACAAAAGT TCATTACATAGATATAAAGCAGATGAATCCTATTTAGTTGGAAGTGATTTAGGTCCTGCT GAAAGTTATTTAAATATTGAGCGTATCATTGATGTAGCAAAACAAGCGAATGTGGATGCG ATTCATCCTGGCTATGGATTTTTAAGTGAAAATGAACAATTTGCGCGTCGTTGTGCAGAA GAAGGAATTAAATTTATTGGTCCTCATTTAGAACATTTAGATATGTTTGGAGATAAAGTT AAAGCTCGTACAACGGCTATCAAGGCAGATTTACCAGTTATTCCTGGTACAGACGGTCCA ATTAAATCATATGAATTAGCAAAAGAATTTGCAGAAGAAGCTGGTTTCCCGCTAATGATT AAAGCCACAAGTGGTGGCGGCGGTAAAGGTATGAGAATCGTTCGTGAAGAAAGTGAATTA GAAGATGCTTTCCATAGAGCAAAATCAGAAGCTGAAAAATCATTTGGTAATAGTGAAGTT TACATAGAAAGATACATTGATAATCCAAAGCATATTGAAGTACAAGTCATAGGTGACGAA CATGGAAATATCGTACACTTATTTGAACGTGATTGTTCAGTACAACGTCGTCATCAAAAA GTTGTAGAAGTTGCACCATCAGTTGGATTATCACCAACATTACGTCAACGTATTTGTGAT GCTGCAATTCAATTGATGGAAAATATTAAATATGTCAATGCAGGTACTGTTGAATTTCTA GTATCTGGTGACGAATTCTTCTTTATAGAAGTTAACCCTCGTGTACAAGTAGAGCATACA ATTACAGAGATGGTAACAGGAATTGATATTGTTAAGACACAAATTTTAGTTGCAGCAGGT GCCGATTTATTTGGTGAAGAGATTAATATGCCGCAACAAAAAGATATTACAACATTAGGC TATGCCATCCAATGTCGTATTACAACAGAAGATCCGTTAAATGATTTCATGCCGGATACT GGAACAATCATTGCTTATCGTTCAAGCGGTGGCTTTGGTGTACGTCTTGATGCTGGAGAT GGTTTCCAAGGTGCTGAGATATCACCTTATTATGATTCATTACTCGTAAAATTATCTACA CATGCGATATCATTTAAACAAGCAGAAGAAAAAATGGTACGTTCATTACGAGAAATGCGT ATTCGTGGTGTTAAAACTAATATTCCATTCTTAATTAATGTAATGAAGAATAAAAAGTTC ACAAGTGGTGATTACACAACTAAATTTATTGAAGAAACACCAGAACTTTTCGACATTCAG CCGTCTCTAGATAGAGGTACTAAAACATTAGAATATATAGGTAATGTAACAATTAATGGT TTCCCAAATGTTGAGAAACGTCCGAAACCAGACTATGAATTAGCATCAATTCCAACTGTA TCTTCAAGTAAAATCGCTTCATTTAGTGGTACGAAACAATTGCTTGATGAAGTAGGTCCA AAAGGTGTAGCTGAATGGGTTAAAAAGCAGGATGATGTCTTACTAACAGATACAACCTTT AGAGATGCACACCAATCATTATTAGCTACACGAGTTAGAACTAAGGATATGATTAATATC GCATCCAAAACAGCGGACGTATTTAAAGATGGTTTCTCACTAGAAATGTGGGGCGGTGCT ACATTTGATGTGGCATATAATTTCTTGAAGGAAAACCCATGGGAACGACTTGAACGTCTA CGTAAAGCTATCCCAAATGTATTATTCCAAATGTTGTTACGTGCTTCAAACGCAGTTGGT TATAAAAACTATCCTGATAATGTTATTCATAAATTCGTACAAGAAAGTGCTAAAGCAGGC ATAGATGTCTTTAGAATTTTCGATTCATTAAACTGGGTAGATCAAATGAAAGTTGCCAAT GAAGCAGTACAAGAAGCGGGCAAAATCTCTGAAGGTACTATTTGTTATACAGGTGACATT TTAAATCCTGAGCGATCAAACATTTATACTTTAGAGTATTATGTCAAACTAGCTAAAGAG TTAGAACGTGAAGGTTTCCATATTTTAGCGATTAAAGATATGGCAGGCTTATTAAAACCT AAAGCCGCTTACGAATTGATTGGTGAGTTAAAATCAGCTGTAGATTTACCAATTCATCTT CACACTCATGATACAAGTGGTAATGGTTTATTAACATACAAACAAGCAATAGATGCTGGG GTCGATATCATTGATACTGCTGTTGCTTCAATGAGTGGTTTAACAAGTCAGCCAAGCGCC AATTCGTTATATTATGCATTAAATGGCTTCCCACGCCACCTTAGAACTGATATTGAAGGT ATGGAGTCACTTAGTCATTATTGGTCAACTGTACGTACTTATTATTCAGACTTTGAAAGT GATATCAAATCACCGAATACTGAAATTTATCAACATGAAATGCCTGGTGGACAGTATTCG AATTTAAGTCAACAAGCTAAAAGTTTAGGTTTAGGCGAAAGATTTGATGAAGTCAAAGAT ATGTATCGCAGAGTGAATTTCTTATTTGGTGATATCGTAAAAGTAACTCCATCGTCTAAA GTAGTTGGTGATATGGCACTTTATATGGTACAAAATGATCTTGATGAACAATCCGTGATT ACAGATGGCTATAAATTAGATTTCCCAGAATCAGTAGTGTCGTTCTTCAAAGGCGAAATA GGACAACCTGTAAATGGTTTTAATAAAGATTTACAAGCGGTTATTTTAAAAGGCCAAGAA GCACTAACAGCTCGTCCAGGTGAATATCTAGAGCCAGTTGATTTTGAAAAAGTCCGTGAG TTGCTTGAAGAAGAGCAACAAGGTCCTGTTACGGAGCAAGATATTATTAGTTATGTATTA TATCCAAAAGTATATGAACAATATATTCAAACTAGAAATCAATACGGAAACTTATCGTTA CTTGATACGCCTACATTCTTCTTTGGAATGCGTAATGGTGAAACAGTAGAAATCGAAATC GATAAGGGTAAACGATTAATTATTAAACTAGAAACGATTAGTGAACCAGATGAAAATGGT AATAGAACGATTTACTATGCGATGAATGGTCAAGCGAGACGTATTTACATTAAAGATGAA AATGTGCATACAAATGCGAACGTTAAGCCAAAAGCAGATAAGAGTAATCCAAGTCATATC GGTGCTCAAATGCCAGGTTCAGTAACTGAAGTCAAGGTTAGTGTTGGTGAAACTGTGAAA GCTAATCAGCCGTTGCTAATTACTGAAGCTATGAAAATGGAAACAACAATTCAAGCACCA TTTGACGGTGTGATTAAACAAGTAACTGTAAATAATGGTGACACAATAGCGACAGGCGAT TTATTAATCGAAATTGAAAAAGCAACTGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID A0A0H3JRU9 UniProtKB Entry Name A0A0H3JRU9_STAAM GenBank Protein ID 14245768 GenBank Gene ID BA000017 - General References
- Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, Murakami H, Hosoyama A, Mizutani-Ui Y, Takahashi NK, Sawano T, Inoue R, Kaito C, Sekimizu K, Hirakawa H, Kuhara S, Goto S, Yabuzaki J, Kanehisa M, Yamashita A, Oshima K, Furuya K, Yoshino C, Shiba T, Hattori M, Ogasawara N, Hayashi H, Hiramatsu K: Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet. 2001 Apr 21;357(9264):1225-40. [Article]
- Xiang S, Tong L: Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct Mol Biol. 2008 Mar;15(3):295-302. doi: 10.1038/nsmb.1393. Epub 2008 Feb 24. [Article]
- Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L: A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10;17(6):823-32. doi: 10.1016/j.str.2009.04.008. [Article]
- Yu LP, Chou CY, Choi PH, Tong L: Characterizing the importance of the biotin carboxylase domain dimer for Staphylococcus aureus pyruvate carboxylase catalysis. Biochemistry. 2013 Jan 22;52(3):488-96. doi: 10.1021/bi301294d. Epub 2013 Jan 9. [Article]