2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Details

Name

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Synonyms

• 4.6.1.12

Gene Name

ispF

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Amino acid sequence

>lcl|BSEQ0022337|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
MMLPRVGLGTDVHPIEAGRPCRLLCLEFDDADGCAGHSDGDVAAHALCDALLSAAGLGDL
GTIFGTDRPQWRGASGADMIRHVRGLVENAGFVIGNATVQVIGNRPKVGPRREEAQQVLS
ELVGAPVSVSATTTDGLGLTGRGEGLAAIATALVAAEPVGDAK

Number of residues

163

Molecular Weight

16546.59

Theoretical pI

4.74

GO Classification

Functions

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity / metal ion binding / nucleotide binding

Processes

terpenoid biosynthetic process

General Function

Nucleotide binding

Specific Function

Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).

Pfam Domain Function

• YgbB (PF02542)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0022338|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
ATGATGCTGCCTCGCGTCGGGCTCGGCACCGACGTCCACCCGATCGAGGCAGGCCGCCCG
TGTCGTCTGCTGTGCCTGGAATTCGACGACGCCGACGGCTGCGCAGGCCACTCCGACGGA
GACGTCGCGGCCCACGCGCTGTGTGATGCGCTACTCAGCGCGGCCGGGCTGGGCGATCTC
GGCACGATATTCGGCACCGACCGCCCGCAGTGGCGCGGTGCCAGCGGCGCCGACATGATT
CGCCACGTGCGCGGGCTCGTCGAGAACGCGGGCTTCGTCATCGGCAACGCAACGGTACAG
GTCATCGGCAATCGGCCCAAGGTGGGCCCACGGCGCGAAGAGGCACAGCAGGTGCTCTCC
GAGCTGGTGGGAGCCCCGGTGTCGGTGTCGGCCACCACCACCGACGGCCTCGGGCTGACC
GGCCGCGGCGAGGGTCTGGCAGCCATCGCCACGGCCCTCGTGGCCGCCGAACCGGTCGGT
GATGCAAAGTAG

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	A0R559
UniProtKB Entry Name	A0R559_MYCS2
GenBank Protein ID	118169404
GenBank Gene ID	CP000480

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04714	ISOPENTENYL PYROPHOSPHATE	experimental	unknown		Details