5-hydroxytryptamine receptor 3E
Details
- Name
- 5-hydroxytryptamine receptor 3E
- Synonyms
- 5-HT3-E
- Serotonin receptor 3E
- Gene Name
- HTR3E
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008663|5-hydroxytryptamine receptor 3E MEGSWFHRKRFSFYLLLGFLLQGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNI SVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNL WLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTF SSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFY VAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLL PTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRC CPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHS VELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
- Number of residues
- 456
- Molecular Weight
- 51437.415
- Theoretical pI
- Not Available
- GO Classification
- Functionsserotonin receptor activity / serotonin-activated cation-selective channel activityProcessescation transmembrane transport / ion transmembrane transport / neurological system process / regulation of membrane potential / serotonin receptor signaling pathway / transmembrane transportComponentsintegral component of membrane / neuron projection / plasma membrane / synapse
- General Function
- Serotonin-activated cation-selective channel activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
- Pfam Domain Function
- Transmembrane Regions
- 249-269 283-303 308-328 434-454
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0021420|5-hydroxytryptamine receptor 3E (HTR3E) ATGGAAGGAAGCTGGTTCCACAGGAAAAGATTTTCCTTCTACCTCCTTCTCGGTTTTCTG CTTCAAGGAAGGGGCGTTACTTTCACCATCAATTGCTCAGGGTTTGGCCAGCACGGGGCG GATCCCACTGCTCTGAATTCAGTGTTTAATAGAAAGCCCTTCCGTCCGGTCACCAACATC AGCGTCCCCACCCAAGTCAACATCTCCTTCGCGATGTCTGCCATCCTAGATGTGAATGAA CAGCTGCACCTCTTGTCATCATTCCTGTGGCTGGAAATGGTTTGGGATAACCCATTTATC AGCTGGAACCCAGAGGAATGTGAGGGCATCACGAAGATGAGTATGGCAGCCAAGAACCTG TGGCTCCCAGACATTTTCATCATTGAACTCATGGATGTGGATAAGACCCCAAAAGGCCTC ACAGCATATGTAAGTAATGAAGGTCGCATCAGGTATAAGAAACCCATGAAGGTGGACAGT ATCTGTAACCTGGACATCTTCTACTTCCCCTTCGACCAGCAGAACTGCACACTCACCTTC AGCTCATTCCTCTACACAGTGGACAGCATGTTGCTGGACATGGAGAAAGAAGTGTGGGAA ATAACAGACGCATCCCGGAACATCCTTCAGACCCATGGAGAATGGGAGCTCCTGGGCCTC AGCAAGGCCACCGCAAAGTTGTCCAGGGGAGGCAACCTGTATGATCAGATCGTGTTCTAT GTGGCCATCAGGCGCAGGCCCAGTCTCTATGTCATAAACCTTCTCGTGCCCAGTGGCTTT CTGGTTGCCATCGATGCCCTCAGCTTCTACCTGCCAGTGAAAAGTGGGAATCGTGTCCCA TTCAAGATAACGCTCCTGCTGGGCTACAACGTCTTCCTGCTCATGATGAGTGACTTGCTC CCCACCAGTGGCACCCCCCTCATCGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTG GGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCC CCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGC TGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCC GGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTG ACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCA GTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTG CTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTCTGGAACACCTAG
- Chromosome Location
- 3
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID A5X5Y0 UniProtKB Entry Name 5HT3E_HUMAN HGNC ID HGNC:24005 - General References
- Niesler B, Frank B, Kapeller J, Rappold GA: Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene. 2003 May 22;310:101-11. [Article]
- Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW, Roberds SL: A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene. 2003 Nov 13;319:137-48. [Article]
- Niesler B, Walstab J, Combrink S, Moller D, Kapeller J, Rietdorf J, Bonisch H, Gothert M, Rappold G, Bruss M: Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol. 2007 Jul;72(1):8-17. Epub 2007 Mar 28. [Article]
- Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP, Courtenay N, Luck J, Rhodes A, Modha S, Moore SE, Sanger GJ, Gunthorpe MJ: Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J Neurochem. 2009 Jan;108(2):384-96. doi: 10.1111/j.1471-4159.2008.05775.x. Epub 2008 Nov 29. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB13025 Tiapride investigational yes antagonist Details DB09304 Setiptiline experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB12141 Gilteritinib approved, investigational no inhibitor Details DB00715 Paroxetine approved, investigational unknown Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn yes inhibitor Details DB00898 Ethanol approved unknown Details DB00246 Ziprasidone approved unknown antagonist Details