Tripartite terminase subunit 1
Details
- Name
- Tripartite terminase subunit 1
- Synonyms
- Not Available
- Gene Name
- TRM1
- Organism
- Human Cytomegalovirus
- Amino acid sequence
>lcl|BSEQ0051322|Tripartite terminase subunit 1 MEMNLLQKLCVVCSKCNEYAMELECLKYCDPNVLLAESTPFKRNAAAIVYLYRKIYPEVV AQNRTQSSLLTLYLEMLLKALHEDTALLDRALMAYSRQPDRAAFYRTVLRLDRCDRHHTV ELQFTDNVRFSVSLATLNDIERFLCKMNYVYGILAPEAGLEVCAQLLELLRRLCGISPVA RQEVYVEGTTCAQCYEELTIIPNQGRSLNKRLQGLLCNHIAVHRPSSQSDVNIQTVEQDL LDLTTRIPHLAGVLSALKSLFSSSSAYHSYIQEAEEALREYNLFTDIPERIYSLSDFTYW SRTSEVIVKRVGITIQQLNVYHQLCRALMNGISRHLYGEDVEDIFVLGEKALDGEERMFV GSVFAAPNRIIDLITSLSIQAFEDNPVFNKLHESNEMYTKIKHILEEIRRPLPDGTGGDG PEGEVIHLRGREAMSGTGTTLMTASNSSNSSTHSQRNNGGGGRARGGGKKAVGGGANGQD GDGSENGLRVRNCDEHEALDLVDARSRIHNVTREVNVRKRAYLQKVSEVGYGKVIRCIKT QERLTSKLIDVNLVGPLCLDFISKLMNGFLYRSQYHQDQDVVDVGNQFTYDEHLYVVNNL IHKSLPVESLPLLGQQIYELCNGPLFTHCTDRYPLSHNVDMAYACDNAGVLPHVKDDLVK CAEGTVYPSEWMVVKYMGFFNFSDCQDLNVLQKEMWMHVRELVLSVALYNETFGKQLSIA CLRDELHPDRDVILTYNKEWPLLLRHEGSLYKSKDLYLLLYRHLSRPDESGDVPTAPVAK PSTLTAAAAVSGAFREPDRPWLPSPYPSSSTAGVSRRVRATRKRPRRASSLLDLARDEHG IQDLVPGSLR
- Number of residues
- 850
- Molecular Weight
- 95810.305
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / metal ion bindingProcessesviral DNA genome packaging / viral release from host cellComponentshost cell nucleus
- General Function
- Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
- Specific Function
- Atp binding
- Pfam Domain Function
- PRTP (PF01366)
- Transmembrane Regions
- Not Available
- Cellular Location
- Host nucleus
- Gene sequence
>lcl|BSEQ0051323|Tripartite terminase subunit 1 (TRM1) ATGGAGATGAATTTGTTACAGAAACTATGCGTAGTGTGTTCGAAATGCAACGAATACGCC ATGGAGCTGGAGTGTCTAAAGTACTGCGATCCGAACGTGTTACTGGCGGAGTCCACGCCG TTCAAGAGAAACGCGGCGGCTATAGTGTATCTGTACCGGAAGATCTACCCGGAGGTGGTG GCGCAGAATCGTACGCAGAGTTCGCTGCTGACTCTCTATCTGGAGATGCTGCTGAAGGCG CTGCACGAGGATACGGCTTTGCTGGATCGGGCGCTGATGGCCTACTCGCGCCAGCCGGAC CGGGCGGCCTTCTACCGTACCGTCCTCCGTTTGGATCGCTGCGATCGCCATCACACCGTG GAGCTCCAGTTTACGGACAACGTCCGTTTCAGCGTCAGTCTGGCCACACTCAACGACATC GAGCGCTTCCTGTGCAAAATGAACTACGTGTACGGGATCCTGGCGCCGGAGGCCGGCCTG GAGGTCTGCGCGCAGCTGCTGGAGCTCCTCCGTCGCCTATGCGGCATCTCGCCGGTGGCG CGTCAGGAAGTGTACGTCGAAGGGACGACATGCGCCCAATGCTACGAGGAGCTGACCATC ATCCCGAATCAGGGCCGCTCGCTGAACAAGCGGCTGCAGGGCTTGCTGTGCAACCATATA GCGGTCCACCGTCCGTCAAGCCAGTCCGATGTGAATATCCAGACGGTGGAGCAGGACCTG CTGGACCTGACAACGCGCATCCCCCACTTGGCTGGAGTCCTTTCGGCCCTCAAAAGCCTA TTCTCTTCTTCATCGGCCTACCACAGCTACATCCAGGAGGCGGAGGAGGCGCTGAGGGAG TACAACCTGTTTACGGATATACCGGAACGAATATATTCCTTGTCGGATTTTACCTACTGG TCCCGTACCTCGGAGGTTATCGTCAAGCGGGTGGGCATCACCATCCAGCAGCTAAATGTG TATCACCAGCTGTGCCGGGCGCTCATGAACGGCATCAGTCGCCATCTGTACGGGGAGGAC GTGGAGGACATCTTCGTGCTCGGGGAAAAGGCGTTGGACGGGGAGGAGCGCATGTTCGTG GGGTCGGTCTTTGCCGCCCCCAACAGGATCATCGACCTCATCACATCCCTCAGCATTCAA GCTTTCGAGGACAACCCGGTGTTCAACAAGCTCCACGAAAGCAACGAGATGTACACCAAA ATCAAGCATATTCTCGAGGAGATTCGACGTCCGCTGCCCGATGGCACGGGGGGCGACGGC CCCGAGGGCGAGGTTATTCACCTGCGTGGACGGGAGGCGATGTCGGGGACGGGTACGACT TTGATGACGGCCAGCAACAGCAGCAACAGCAGTACTCACAGTCAGAGGAATAACGGTGGC GGCGGCCGGGCCCGTGGAGGAGGCAAGAAAGCTGTAGGGGGAGGGGCGAATGGGCAGGAC GGCGACGGCAGCGAAAACGGCTTACGGGTGCGCAACTGCGACGAACACGAAGCTCTCGAC TTGGTGGACGCGCGTTCCCGCATCCACAACGTCACCCGCGAGGTGAACGTGCGCAAACGC GCCTACCTGCAGAAGGTCTCGGAGGTGGGCTATGGCAAGGTGATCCGTTGCATCAAAACG CAGGAGCGTCTGACTAGCAAACTCATCGATGTCAACCTAGTGGGGCCCTTGTGTCTGGAC TTTATCTCTAAGCTCATGAATGGGTTTCTATACCGCAGCCAATACCACCAGGACCAAGAC GTGGTGGACGTGGGGAATCAGTTCACGTACGATGAGCACCTGTATGTGGTCAATAACCTG ATCCACAAGAGTCTGCCTGTGGAATCCCTCCCGCTACTGGGTCAGCAGATCTACGAGTTG TGTAACGGGCCCCTCTTCACACACTGTACCGATCGCTATCCCCTCTCTCACAATGTGGAC ATGGCCTATGCCTGCGACAACGCGGGCGTACTACCCCACGTCAAGGACGATTTGGTCAAA TGCGCGGAAGGTACCGTGTATCCCAGTGAGTGGATGGTGGTGAAGTACATGGGTTTTTTC AATTTTTCGGACTGTCAGGACCTAAACGTGCTGCAGAAGGAGATGTGGATGCACGTGCGG GAGCTCGTGCTCTCCGTCGCACTATATAATGAAACTTTCGGGAAACAACTCTCGATCGCG TGCCTGCGCGACGAACTGCACCCGGACAGAGATGTGATTCTCACGTATAACAAAGAGTGG CCGCTGCTGCTTCGTCACGAAGGAAGTCTTTATAAGTCCAAAGATCTATATCTCCTCCTC TACAGGCATCTGTCCAGACCGGATGAGAGTGGCGACGTGCCAACAGCTCCCGTGGCCAAG CCCTCCACCCTGACGGCCGCCGCGGCCGTCTCGGGTGCCTTCAGGGAGCCGGACCGACCT TGGCTGCCAAGTCCGTACCCCTCCTCCTCGACCGCGGGCGTTTCCCGGAGGGTCCGCGCA ACACGCAAGAGACCACGACGCGCCTCATCGCTGCTGGATTTGGCCCGCGACGAACATGGA ATCCAGGATCTGGTGCCTGGTAGTCTGCGTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID F5HC79 UniProtKB Entry Name TRM1_HCMVM - General References
- Dolan A, Cunningham C, Hector RD, Hassan-Walker AF, Lee L, Addison C, Dargan DJ, McGeoch DJ, Gatherer D, Emery VC, Griffiths PD, Sinzger C, McSharry BP, Wilkinson GW, Davison AJ: Genetic content of wild-type human cytomegalovirus. J Gen Virol. 2004 May;85(Pt 5):1301-12. [Article]
- Scholz B, Rechter S, Drach JC, Townsend LB, Bogner E: Identification of the ATP-binding site in the terminase subunit pUL56 of human cytomegalovirus. Nucleic Acids Res. 2003 Mar 1;31(5):1426-33. [Article]
- Champier G, Couvreux A, Hantz S, Rametti A, Mazeron MC, Bouaziz S, Denis F, Alain S: Putative functional domains of human cytomegalovirus pUL56 involved in dimerization and benzimidazole D-ribonucleoside activity. Antivir Ther. 2008;13(5):643-54. [Article]