Microsomal glutathione S-transferase 3

Details

Name
Microsomal glutathione S-transferase 3
Synonyms
  • 2.5.1.18
  • Microsomal GST-3
  • Microsomal GST-III
Gene Name
MGST3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0011641|Microsomal glutathione S-transferase 3
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
Number of residues
152
Molecular Weight
16516.185
Theoretical pI
9.68
GO Classification
Functions
glutathione peroxidase activity / glutathione transferase activity / peroxidase activity
Processes
glutathione derivative biosynthetic process / lipid metabolic process / response to organonitrogen compound / signal transduction / small molecule metabolic process / xenobiotic metabolic process
Components
endoplasmic reticulum membrane / extracellular exosome / integral component of membrane / intracellular membrane-bounded organelle / membrane / nuclear envelope
General Function
Peroxidase activity
Specific Function
Also functions as a glutathione peroxidase.
Pfam Domain Function
Transmembrane Regions
9-29 71-91 120-140
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011642|Microsomal glutathione S-transferase 3 (MGST3)
ATGGCTGTCCTCTCTAAGGAATATGGTTTTGTGCTTCTAACTGGTGCTGCCAGCTTTATA
ATGGTGGCCCACCTAGCCATCAATGTTTCCAAGGCCCGCAAGAAGTACAAAGTGGAGTAT
CCTATCATGTACAGCACGGACCCTGAAAATGGGCACATCTTCAACTGCATTCAGCGAGCC
CACCAGAACACGTTGGAAGTGTATCCTCCCTTCTTATTTTTTCTAGCTGTTGGAGGTGTT
TACCACCCGCGTATAGCTTCTGGCCTGGGCTTGGCCTGGATTGTTGGACGAGTTCTTTAT
GCTTATGGCTATTACACGGGAGAACCCAGCAAGCGTAGTCGAGGAGCCCTGGGGTCCATC
GCCCTCCTGGGCTTGGTGGGCACAACTGTGTGCTCTGCTTTCCAGCATCTTGGTTGGGTT
AAAAGTGGCTTGGGCAGTGGACCCAAATGCTGCCATTAA
Chromosome Location
1
Locus
1q23
External Identifiers
ResourceLink
UniProtKB IDO14880
UniProtKB Entry NameMGST3_HUMAN
GenBank Protein ID2583081
GenBank Gene IDAF026977
GenAtlas IDMGST3
HGNC IDHGNC:7064
General References
  1. Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW: Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. J Biol Chem. 1997 Sep 5;272(36):22934-9. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00143Glutathioneapproved, investigational, nutraceuticalunknownDetails
DB14924Ritlecitinibapproved, investigationalunknownsubstrateDetails