Aurora kinase A


Aurora kinase A
  • AIK
  • AIRK1
  • ARK-1
  • ARK1
  • AURA
  • Aurora 2
  • Aurora-related kinase 1
  • Aurora/IPL1-related kinase 1
  • AYK1
  • Breast tumor-amplified kinase
  • BTAK
  • hARK1
  • IAK1
  • Serine/threonine-protein kinase 15
  • Serine/threonine-protein kinase 6
  • Serine/threonine-protein kinase aurora-A
  • STK15
  • STK6
Gene Name
Amino acid sequence
>lcl|BSEQ0001973|Aurora kinase A
Number of residues
Molecular Weight
Theoretical pI
GO Classification
ATP binding / histone serine kinase activity / protein kinase activity / protein kinase binding / protein serine/threonine kinase activity / protein serine/threonine/tyrosine kinase activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process / anterior/posterior axis specification / cell division / centrosome localization / G2/M transition of mitotic cell cycle / mitotic cell cycle / mitotic centrosome separation / mitotic nuclear division / mitotic spindle organization / negative regulation of apoptotic process / negative regulation of protein binding / neuron projection extension / positive regulation of mitotic nuclear division / positive regulation of oocyte maturation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein autophosphorylation / protein localization to centrosome / protein phosphorylation / regulation of centrosome cycle / regulation of cytokinesis / regulation of protein stability / response to estradiol / spindle assembly involved in female meiosis I / spindle stabilization
axon hillock / centriole / centrosome / chromosome passenger complex / cilium / condensed nuclear chromosome, centromeric region / cytosol / germinal vesicle / meiotic spindle / microtubule / microtubule cytoskeleton / midbody / mitotic spindle / nucleus / perinuclear region of cytoplasm / pronucleus / spindle / spindle midzone / spindle pole centrosome
General Function
Protein serine/threonine/tyrosine kinase activity
Specific Function
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Gene sequence
>lcl|BSEQ0016278|Aurora kinase A (AURKA)
Chromosome Location
External Identifiers
UniProtKB IDO14965
GenBank Protein ID2641948
GenBank Gene IDD84212
General References
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  8. Walter AO, Seghezzi W, Korver W, Sheung J, Lees E: The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene. 2000 Oct 5;19(42):4906-16. [Article]
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  18. Dutertre S, Cazales M, Quaranta M, Froment C, Trabut V, Dozier C, Mirey G, Bouche JP, Theis-Febvre N, Schmitt E, Monsarrat B, Prigent C, Ducommun B: Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci. 2004 May 15;117(Pt 12):2523-31. Epub 2004 May 5. [Article]
  19. Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S: Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004 Jan;36(1):55-62. Epub 2003 Dec 14. [Article]
  20. Sasayama T, Marumoto T, Kunitoku N, Zhang D, Tamaki N, Kohmura E, Saya H, Hirota T: Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1. Genes Cells. 2005 Jul;10(7):627-38. [Article]
  21. Zhao ZS, Lim JP, Ng YW, Lim L, Manser E: The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell. 2005 Oct 28;20(2):237-49. [Article]
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  25. Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA: HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell. 2007 Jun 29;129(7):1351-63. [Article]
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  33. Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G: Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci. 2009 May 1;122(Pt 9):1334-41. doi: 10.1242/jcs.044321. Epub 2009 Apr 7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails