N-acetylglucosamine-6-phosphate deacetylase

Details

Name
N-acetylglucosamine-6-phosphate deacetylase
Synonyms
  • 3.5.1.25
  • GlcNAc 6-P deacetylase
Gene Name
nagA
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0011203|N-acetylglucosamine-6-phosphate deacetylase
MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMI
DIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAA
EESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPE
EDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIG
TALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSV
TVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSV
TVGKDADLVIVSSDCEVILTICRGNIAFISKEADQI
Number of residues
396
Molecular Weight
42621.955
Theoretical pI
5.4
GO Classification
Functions
iron ion binding / N-acetylglucosamine-6-phosphate deacetylase activity / protein homodimerization activity
Processes
carbohydrate metabolic process / N-acetylglucosamine catabolic process / N-acetylneuraminate catabolic process
General Function
Protein homodimerization activity
Specific Function
Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011204|N-acetylglucosamine-6-phosphate deacetylase (nagA)
ATGGCAGAGAGTCTTCTTATCAAAGACATTGCGATCGTGACAGAAAATGAAGTAATCAAA
AACGGCTATGTCGGAATCAATGACGGAAAAATCAGCACAGTTTCAACAGAACGGCCCAAG
GAGCCATATTCAAAAGAGATTCAAGCACCTGCGGATTCCGTTTTGCTTCCCGGCATGATT
GACATTCATATCCACGGCGGCTATGGCGCAGATACAATGGATGCTAGCTTTTCCACGCTC
GACATCATGTCGTCAAGACTGCCCGAAGAAGGCACGACGAGCTTTTTAGCCACAACGATT
ACCCAAGAGCATGGGAACATTTCTCAAGCTTTGGTGAACGCAAGAGAGTGGAAAGCGGCT
GAAGAGTCCTCTTTATTAGGTGCAGAACTGCTCGGCATTCATTTAGAGGGCCCCTTTGTT
TCGCCTAAAAGAGCCGGAGCGCAGCCAAAGGAGTGGATTAGGCCTTCGGATGTTGAGCTT
TTCAAAAAGTGGCAGCAGGAGGCGGGCGGACTGATCAAAATTGTTACACTTGCGCCGGAG
GAGGATCAGCATTTTGAACTGATCCGCCATTTGAAAGACGAATCGATTATCGCATCCATG
GGGCACACGGATGCCGATTCCGCATTGCTGTCGGATGCCGCAAAAGCAGGGGCGAGCCAT
ATGACTCATCTGTACAACGCGATGAGCCCGTTTCATCACCGAGAGCCCGGAGTGATCGGA
ACGGCGCTGGCCCATGATGGGTTTGTGACAGAGCTTATCGCCGATGGCATTCACTCCCAT
CCTTTAGCTGCAAAGCTTGCTTTTTTGGCGAAAGGCAGCAGCAAGCTCATTTTAATTACC
GATTCCATGAGGGCAAAAGGACTGAAAGACGGCGTATATGAGTTCGGCGGCCAAAGTGTG
ACGGTAAGAGGACGAACAGCACTTCTTTCAGACGGAACCCTTGCCGGTTCGATCCTCAAA
ATGAACGAAGGCGCACGGCATATGCGTGAGTTTACAAATTGCTCTTGGACGGATATAGCT
AATATAACTTCTGAAAACGCGGCCAAACAGCTGGGCATCTTTGACCGAAAAGGCAGTGTG
ACTGTGGGAAAAGATGCAGATTTGGTGATTGTCAGCAGTGATTGCGAGGTGATTCTCACC
ATTTGCCGCGGAAACATTGCATTTATATCCAAGGAGGCTGACCAGATATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO34450
UniProtKB Entry NameNAGA_BACSU
GenBank Gene IDAF017113
General References
  1. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  2. Vincent F, Yates D, Garman E, Davies GJ, Brannigan JA: The three-dimensional structure of the N-acetylglucosamine-6-phosphate deacetylase, NagA, from Bacillus subtilis: a member of the urease superfamily. J Biol Chem. 2004 Jan 23;279(4):2809-16. Epub 2003 Oct 13. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02657Glucosamine 6-PhosphateexperimentalunknownDetails