Aquaporin-9
Details
- Name
- Aquaporin-9
- Synonyms
- AQP-9
- Aquaglyceroporin-9
- Small solute channel 1
- SSC1
- Gene Name
- AQP9
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052498|Aquaporin-9 MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITI NVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATV FGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF DSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAG NNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM
- Number of residues
- 295
- Molecular Weight
- 31430.77
- Theoretical pI
- Not Available
- GO Classification
- Functionsamine transmembrane transporter activity / carboxylic acid transmembrane transporter activity / glycerol channel activity / polyol transmembrane transporter activity / purine nucleobase transmembrane transporter activity / pyrimidine nucleobase transmembrane transporter activity / urea channel activity / urea transmembrane transporter activity / water channel activity / water transmembrane transporter activityProcessesamine transport / canalicular bile acid transport / carboxylic acid transport / cellular response to cAMP / excretion / glycerol transport / polyol transport / purine nucleobase transport / pyrimidine nucleobase transport / response to mercury ion / response to organic substance / response to osmotic stress / urea transmembrane transport / water homeostasis / water transportComponentsbasolateral plasma membrane / integral component of membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / plasma membrane
- General Function
- Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.
- Specific Function
- Amine transmembrane transporter activity
- Pfam Domain Function
- MIP (PF00230)
- Transmembrane Regions
- 28-48 55-75 100-124 159-179 190-209 246-266
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052499|Aquaporin-9 (AQP9) ATGCAGCCTGAGGGAGCAGAAAAGGGAAAAAGCTTCAAGCAGAGACTGGTCTTGAAGAGC AGCTTAGCGAAAGAAACCCTCTCTGAGTTCTTGGGCACGTTCATCTTGATTGTCCTTGGA TGTGGCTGTGTTGCCCAAGCTATTCTCAGTCGAGGACGTTTTGGAGGGGTCATCACTATC AATGTTGGATTTTCAATGGCAGTTGCAATGGCCATTTATGTGGCTGGCGGTGTCTCTGGT GGTCACATCAACCCAGCTGTGTCTTTAGCAATGTGTCTCTTTGGACGGATGAAATGGTTC AAATTGCCATTTTATGTGGGAGCCCAGTTCTTGGGAGCCTTTGTGGGGGCTGCAACCGTC TTTGGCATTTACTATGATGGACTTATGTCCTTTGCTGGTGGAAAACTGCTGATCGTGGGA GAAAATGCAACAGCACACATTTTTGCAACATACCCAGCTCCGTATCTATCTCTGGCGAAC GCATTTGCAGATCAAGTGGTGGCCACCATGATACTCCTCATAATCGTCTTTGCCATCTTT GACTCCAGAAACTTGGGAGCCCCCAGAGGCCTAGAGCCCATTGCCATCGGCCTCCTGATT ATTGTCATTGCTTCCTCCCTGGGACTGAACAGTGGCTGTGCCATGAACCCAGCTCGAGAC CTGAGTCCCAGACTTTTCACTGCCTTGGCAGGCTGGGGGTTTGAAGTCTTCAGAGCTGGA AACAACTTCTGGTGGATTCCTGTAGTGGGCCCTTTGGTTGGTGCTGTCATTGGAGGCCTC ATCTATGTTCTTGTCATTGAAATCCACCATCCAGAGCCTGACTCAGTCTTTAAGACAGAA CAATCTGAGGACAAACCAGAGAAATATGAACTCAGTGTCATCATGTAG
- Chromosome Location
- 15
- Locus
- 15q21.3
- External Identifiers
Resource Link UniProtKB ID O43315 UniProtKB Entry Name AQP9_HUMAN HGNC ID HGNC:643 - General References
- Ishibashi K, Kuwahara M, Gu Y, Tanaka Y, Marumo F, Sasaki S: Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. Biochem Biophys Res Commun. 1998 Mar 6;244(1):268-74. [Article]
- Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA: Functional and molecular characterization of the human neutral solute channel aquaporin-9. Am J Physiol. 1999 Nov;277(5 Pt 2):F685-96. [Article]
- Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
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- Gotfryd K, Mosca AF, Missel JW, Truelsen SF, Wang K, Spulber M, Krabbe S, Helix-Nielsen C, Laforenza U, Soveral G, Pedersen PA, Gourdon P: Human adipose glycerol flux is regulated by a pH gate in AQP10. Nat Commun. 2018 Nov 12;9(1):4749. doi: 10.1038/s41467-018-07176-z. [Article]