Guanylate cyclase soluble subunit beta-2

Details

Name

Guanylate cyclase soluble subunit beta-2

Synonyms

• 4.6.1.2
• GCS-beta-2

Gene Name

GUCY1B2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052580|Guanylate cyclase soluble subunit beta-2
MSGYDRMLRTLGGNLMEFIENLDALHSYLALSYQEMNAPSFRVERGADGKMFLHYYSDRS
GLCHIVPGIIEAVAKDFFDIDVIMDILDMNEEVERTGKKEHVVFLIVQKAHRKMRKTKPK
RLQDSQGMERDQEALQAAFLKMKEKYLNVSACPVKKSHWDVVRSIVMFGKGHLMNTFEPI
YPERLWIEEKTFCNAFPFHIVFDESLQVKQARVNIQKYVPGLQTQNIQLDEYFSIIHPQV
TFNIFSIRRFINSQFVLKTRREMMPVAWQSRTTLKLQGQMIWMESMWCMVYLCSPKLRSL
QELEELNMHLSDIAPNDTTRDLILLNQQRLAEIELSNQLERKKEELQVLSKHLAIEKKKT
ETLLYAMLPKHVANQLREGKKVAAGEFKSCTILFSDVVTFTNICTACEPIQIVNVLNSMY
SKFDRLTSVHAVYKVETIGDAYMVVGGVPVPIGNHAQRVANFALGMRISAKEVTNPVTGE
PIQLRVGIHTGPVLADVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAYRALKNQ
GFKIIERGEIEVKGKGRMTTYFLIQNLNATEDEIMGRSKTPVDHKGSTQKASLPTTKLQG
SVQPSCPEHSSLASWLL

Number of residues

617

Molecular Weight

70367.22

Theoretical pI

Not Available

GO Classification

Functions

GTP binding / guanylate cyclase activity / heme binding / metal ion binding

Processes

cGMP-mediated signaling

Components

cytoplasm

General Function

Not Available

Specific Function

Gtp binding

Pfam Domain Function

• Guanylate_cyc (PF00211)
• HNOB (PF07700)
• HNOBA (PF07701)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	O75343
UniProtKB Entry Name	GCYB2_HUMAN
HGNC ID	HGNC:4686

General References

1. Behrends S, Vehse K: The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma. Biochem Biophys Res Commun. 2000 Apr 29;271(1):64-9. doi: 10.1006/bbrc.2000.2596. [Article]
2. Behrends S, Kazmierczak B, Steenpa A, Knauf B, Bullerdiek J, Scholz H, Eiberg H: Assignment of GUCY1B2, the gene coding for the beta2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155. Genomics. 1999 Jan 1;55(1):126-7. doi: 10.1006/geno.1998.5613. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB09401	Isosorbide	approved, investigational	yes	activator	Details