Cytosolic 10-formyltetrahydrofolate dehydrogenase

Details

Name

Cytosolic 10-formyltetrahydrofolate dehydrogenase

Synonyms

• 1.5.1.6
• 10-FTHFDH
• Aldehyde dehydrogenase family 1 member L1
• FTHFD

Gene Name

ALDH1L1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0001858|Cytosolic 10-formyltetrahydrofolate dehydrogenase
MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR
AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN
WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV
RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ
KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI
LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL
VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM
PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI
SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI
QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ
VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK
SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH
DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP
RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT
RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF
EY

Number of residues

902

Molecular Weight

98828.505

Theoretical pI

5.76

GO Classification

Functions

aldehyde dehydrogenase (NAD) activity / catalytic activity / formyltetrahydrofolate dehydrogenase activity / hydroxymethyl-, formyl- and related transferase activity / methyltransferase activity

Processes

10-formyltetrahydrofolate catabolic process / biosynthetic process / one-carbon metabolic process

Components

cytoplasm / extracellular exosome / mitochondrion

General Function

Methyltransferase activity

Specific Function

Not Available

Pfam Domain Function

• Aldedh (PF00171)
• PP-binding (PF00550)
• Formyl_trans_N (PF00551)
• Formyl_trans_C (PF02911)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0010656|Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1)
ATGGCAGGTCCTTCCAACCCTCCTGCTACCATGAAGATTGCAGTGATTGGACAGAGCCTG
TTTGGCCAGGAAGTTTACTGCCACCTGAGGAAGGAGGGCCACGAAGTGGTGGGTGTGTTC
ACTGTTCCAGACAAGGATGGAAAGGCCGACCCCCTGGGTCTGGAAGCTGAGAAGGATGGA
GTGCCGGTATTCAAGTACTCCCGGTGGCGTGCAAAAGGACAGGCTTTGCCTGATGTGGTG
GCAAAATACCAGGCTTTGGGGGCCGAGCTCAACGTCCTGCCCTTCTGCAGCCAATTCATC
CCCATGGAGATAATCAGTGCCCCCCGGCATGGCTCCATCATCTATCACCCGTCACTGCTC
CCTAGGCACCGAGGGGCCTCGGCCATCAACTGGACCCTCATTCACGGAGATAAGAAAGGG
GGGTTTTCCATCTTCTGGGCGGATGATGGTCTGGACACCGGAGACCTGCTGCTGCAGAAG
GAGTGTGAGGTGCTCCCGGACGACACCGTGAGCACGCTGTACAACCGCTTCCTCTTCCCT
GAAGGCATCAAAGGGATGGTGCAGGCCGTGAGGCTGATCGCTGAGGGCAAAGCCCCCAGA
CTCCCTCAGCCTGAGGAAGGAGCCACCTATGAGGGGATTCAGAAGAAGGAGACAGCCAAG
ATCAACTGGGACCAGCCGGCAGAGGCCATTCACAACTGGATCCGCGGGAACGACAAGGTG
CCGGGAGCCTGGACAGAGGCCTGTGAACAGAAACTGACATTTTTCAACTCAACGCTGAAC
ACTTCAGGCCTGGTGCCCGAGGGAGACGCTTTGCCCATCCCAGGAGCCCATCGGCCAGGG
GTGGTCACCAAAGCAGGACTCATCCTCTTTGGGAATGATGACAAAATGCTGCTGGTGAAG
AATATTCAGCTGGAGGATGGCAAAATGATCCTGGCCTCGAACTTCTTTAAGGGGGCAGCC
AGCAGTGTCCTTGAGCTGACAGAGGCAGAGCTGGTTACTGCGGAGGCTGTGCGGAGTGTT
TGGCAGCGGATCCTCCCCAAAGTCCTGGAGGTTGAAGACTCCACTGATTTCTTCAAGTCA
GGGGCCGCGTCTGTGGACGTTGTGAGGCTGGTGGAGGAAGTGAAGGAGCTGTGTGATGGC
CTGGAGTTAGAAAATGAAGATGTGTACATGGCATCCACCTTTGGGGACTTCATCCAGCTG
TTAGTGAGGAAGCTGCGAGGGGACGATGAGGAGGGCGAGTGCAGCATTGACTACGTGGAA
ATGGCAGTGAACAAGCGCACTGTCCGCATGCCCCACCAGCTCTTCATTGGGGGGGAGTTC
GTGGATGCCGAGGGCGCCAAGACCTCTGAGACCATCAATCCCACCGATGGAAGTGTCATC
TGCCAGGTATCCCTGGCCCAAGTCACCGACGTCGACAAGGCAGTGGCCGCAGCCAAGGAT
GCCTTTGAGAATGGACGGTGGGGGAAGATCAGTGCGCGGGACCGGGGCCGGCTGATGTAC
AGGTTGGCAGATCTCATGGAGCAGCACCAGGAGGAGCTGGCCACCATTGAGGCCCTGGAT
GCGGGTGCCGTCTACACGCTGGCCCTGAAGACCCACGTGGGCATGTCCATCCAGACCTTC
CGCTACTTTGCTGGCTGGTGTGACAAGATCCAGGGCTCCACCATCCCCATCAACCAGGCC
AGACCCAACCGCAACCTGACCTTGACCAGGAAGGAGCCTGTTGGGGTTTGTGGCATCATC
ATCCCCTGGAACTATCCCCTGATGATGCTGTCCTGGAAGACAGCTGCCTGCCTGGCTGCC
GGGAACACAGTGGTGATCAAGCCTGCTCAGGTGACCCCACTCACAGCCTTGAAGTTTGCA
GAGCTGACATTAAAGGCCGGCATTCCCAAAGGTGTGGTTAACGTCCTCCCAGGATCTGGC
TCCCTGGTCGGCCAGAGACTCTCAGACCATCCTGATGTGAGGAAAATCGGGTTCACAGGC
TCCACAGAGGTGGGCAAGCACATCATGAAAAGCTGTGCCATAAGTAACGTGAAGAAGGTG
TCCCTGGAACTGGGCGGGAAGTCACCCCTCATCATCTTTGCTGACTGTGACCTCAACAAG
GCTGTGCAGATGGGGATGAGTTCTGTTTTCTTCAACAAAGGAGAGAATTGCATTGCAGCA
GGCCGACTCTTTGTGGAGGACTCCATTCATGATGAGTTCGTGCGGAGAGTGGTAGAAGAG
GTGCGGAAGATGAAGGTGGGCAACCCGCTGGACAGGGACACCGACCACGGGCCGCAGAAT
CACCATGCCCACCTTGTGAAGCTGATGGAGTACTGCCAGCATGGCGTGAAGGAAGGGGCC
ACACTGGTCTGCGGCGGGAATCAGGTCCCTCGGCCAGGGTTCTTCTTTGAGCCAACTGTT
TTCACAGACGTGGAAGACCACATGTTCATAGCCAAGGAGGAGTCCTTCGGGCCTGTCATG
ATCATCTCTCGGTTTGCTGATGGGGACTTGGATGCCGTGCTGTCTCGGGCCAATGCCACG
GAATTTGGCCTGGCTTCTGGTGTCTTCACCAGGGACATCAACAAGGCCCTGTATGTCAGT
GACAAGCTCCAGGCAGGCACTGTGTTTGTCAACACGTACAACAAGACCGACGTGGCCGCT
CCCTTCGGAGGATTCAAACAGTCTGGATTTGGCAAAGATCTAGGAGAGGCGGCTCTGAAC
GAGTACCTGCGGGTCAAGACAGTGACCTTCGAATACTGA

Chromosome Location

3

Locus

3q21.2

External Identifiers

Resource	Link
UniProtKB ID	O75891
UniProtKB Entry Name	AL1L1_HUMAN
GenBank Protein ID	3560541
GenBank Gene ID	AF052732
GenAtlas ID	ALDH1L1
HGNC ID	HGNC:3978

General References

1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
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4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00116	Tetrahydrofolic acid	nutraceutical	unknown	cofactor	Details