Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.22.-
- p23
- Gene Name
- Not Available
- Organism
- HCV
- Amino acid sequence
>lcl|BSEQ0021384|Genome polyprotein MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKASERSQPRG RRQPIPKARRPEGRAWAQPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPTDPRRRSRNLG KVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLA LLSCLTIPASAYEVRNVSGIYHVTNDCSNSSIVYEAADVIMHTPGCVPCVREGNSSRCWV ALTPTLAARNASVPTTTIRRHVDLLVGTAAFCSAMYVGDLCGSIFLVSQLFTFSPRRHET VQDCNCSIYPGHVSGHRMAWDMMMNWSPTTALVVSQLLRIPQAVVDMVAGAHWGVLAGLA YYSMVGNWAKVLIVALLFAGVDGETHTTGRVAGHTTSGFTSLFSSGASQKIQLVNTNGSW HINRTALNCNDSLQTGFFAALFYAHKFNSSGCPERMASCRPIDWFAQGWGPITYTKPNSS DQRPYCWHYAPRPCGVVPASQVCGPVYCFTPSPVVVGTTDRSGVPTYSWGENETDVMLLN NTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNRTLICPTDCFRKHPEATYTKCGSG PWLTPRCLVDYPYRLWHYPCTLNFSIFKVRMYVGGVEHRLNAACNWTRGERCNLEDRDRS ELSPLLLSTTEWQILPCAFTTLPALSTGLIHLHQNIVDVQYLYGVGSAFVSFAIKWEYIL LLFLLLADARVCACLWMMLLIAQAEAALENLVVLNAASVAGAHGILSFLVFFCAAWYIKG RLAPGAAYAFYGVWPLLLLLLALPPRAYALDREMAASCGGAVLVGLVFLTLSPYYKVFLT RLIWWLQYFITRAEAHMQVWVPPLNVRGGRDAIILLTCAVHPELIFDITKLLLAILGPLM VLQAGITRVPYFVRAQGLIRACMLVRKVAGGHYVQMAFMKLGALTGTYVYNHLTPLRDWA HAGLRDLAVAVEPVVFSAMETKVITWGADTAACGDIILGLPVSARRGKEIFLGPADSLEG QGWRLLAPITAYSQQTRGVLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCINGVCWT VYHGAGSKTLAGPKGPITQMYTNVDLDLVGWQAPPGARSMTPCSCGSSDLYLVTRHADVI PVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGVFRAAVCTRGVAKAVDFIPVES METTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAA TLGFGAYMSKAHGIDPNIRTGVRTITTGGSITYSTYGKFLADGGCSGGAYDIIICDECHS TDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEIGLSNNGEIPFYGKAI PIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPPIGDVVVVATDAL MTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRSGIYR FVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWES VFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHG PTPLLYRLGAVQNEVILTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSV VIVGRIILSGKPAVVPDREVLYQEFDEMEECASQLPYIEQGMQLAEQFKQKALGLLQTAT KQAEAAAPVVESKWRALETFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSP LTTQNTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVA GALVAFKVMSGEVPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLI AFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLRDV WDWICTVLTDFKTWLQSKLLPRLPGVPFLSCQRGYKGVWRGDGIMQTTCPCGAQIAGHVK NGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFH YVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREDVTFQVGLNQYLVGSQL PCEPEPDVTVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTHHD SPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLHAEGDEREISVAAEILRKSRK FPSALPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPTKAPPIPPPRRKRTVVLTESNV SSALAELATKTFGSSGSSAVDSGTATALPDLASDDGDKGSDVESYSSMPPLEGEPGDPDL SDGSWSTVSEEASEDVVCCSMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATT SRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSKF GYGAKDVRNLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQPEKGGRKPARLIV FPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDT RCFDSTVTESDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRA SGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTE AMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETAR HTPINSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQ IIERLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATC GRYLFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHSLSRARPRWFPLCLLLLSV GVGIYLLPNR
- Number of residues
- 3010
- Molecular Weight
- 326763.605
- Theoretical pI
- 8.17
- GO Classification
- Functions14-3-3 protein binding / ATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / protein kinase binding / protein kinase C binding / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / SMAD binding / structural molecule activity / zinc ion bindingProcessesactivation of protein kinase activity / apoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / negative regulation of protein binding / negative regulation of SMAD protein complex assembly / negative regulation of transforming growth factor beta receptor signaling pathway / pore formation by virus in membrane of host cell / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell cytoplasm / host cell cytosol / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell membrane / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
- General Function
- Zinc ion binding
- Specific Function
- Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity).NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity).NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity).NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
- Pfam Domain Function
- Transmembrane Regions
- 169-189 359-379 726-746 758-778 783-803 814-834 882-902 929-949 1658-1678 1806-1826 1829-1849 1851-1871 1882-1902 2990-3010
- Cellular Location
- Host endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0008332|9033 bp ATGAGCACGAATCCTAAACCTCAAAGAAAAACCAAACGTAACACCAACCGCCGCCCACAG GACGTCAAGTTCCCGGGCGGTGGTCAGATCGTTGGTGGAGTTTACCTGTTGCCGCGCAGG GGCCCCAGGTTGGGTGTGCGCGCGACTAGGAAGACTTCCGAGCGGTCGCAACCTCGTGGA AGGCGACAACCTATCCCAAAGGCTCGCCAACCCGAGGGCAGGGCCTGGGCTCAGCCCGGG TACCCTTGGCCCCTCTATGGCAATGAGGGCTTGGGGTGGGCAGGATGGCTCCTGTCACCC CGCGGCTCCCGGCCTAGTTGGGGCCCCACGGACCCCCGGCGTAGGTCGCGTAACTTGGGT AAGGTCATCGATACCCTTACATGCGGCTTCGCCGATCTCATGGGGTACATTCCGCTCGTC GGCGCCCCCCTAGGGGGCGCTGCCAGGGCCTTGGCACACGGTGTCCGGGTTCTGGAGGAC GGCGTGAACTATGCAACAGGGAACTTGCCCGGTTGCTCTTTCTCTATCTTCCTCTTGGCT CTGCTGTCCTGTTTGACCATCCCAGCTTCCGCTTATGAAGTGCGCAACGTGTCCGGGATA TACCATGTCACGAACGACTGCTCCAACTCAAGCATTGTGTATGAGGCAGCGGACGTGATC ATGCATACTCCCGGGTGCGTGCCCTGTGTTCGGGAGGGCAACAGCTCCCGTTGCTGGGTA GCGCTCACTCCCACGCTCGCGGCCAGAGATGCCAGCGTCCCCACTACGACAATACGACGC CACGTCGACTTGCTCGTTGGGACGGCTGCTTTCTGCTCCGCTATGTACGTGGGGGATCTC TGCGGATCTATTTTCCTCGTCTCCCAGCTGTTCACCTTCTCGCCTCGCCGGCATGAGACA GTGCAGGACTGCAACTGCTCAATCTATCCCGGCCATGTATCAGGTCACCGCATGGCTTGG GATATGATGATGAACTGGTCACCTACAACAGCCCTAGTGGTGTCGCAGTTGCTCCGGATC CCACAAGCTGTCGTGGACATGGTGGCGGGGGCCCACTGGGGAGTCCTGGCGGGCCTTGCC TACTATTCCATGGTAGGGAACTGGGCTAAGGTTCTGATTGTGGCGCTACTCTTTGCCGGC GTTGACGGGGCGACCTACACGTCGGGGGGGGTGGCCGGCCGCACCACCTCCGGGTTCACG TCCCTCTTCTCATCTGGGGCGTCTCAGAAAATCCAGCTTGTGAATACCAACGGCAGCTGG CACATCAACAGGACTGCCCTAAATTGCAATGACTCCCTCCACACTGGGTTCCTTGCCGCG CTGTTCTACACACACAAGTTCAACTCGTCCGGGTGCCCGGAGCGCATGGCCAGCTGCCGC CCCATTGACGGGTTCGCCCAGGGATGGGGCCCCATCACCTATACTGAGCCTAACAGCCCG GATCAGAGGCCTTATTGCTGGCATTACGCGCCTCGACCGTGTGGTATCGTACCCGCGTCG CAGGTGTGTGGTCCAGTGTATTGTTTCACCCCAAGCCCTGTTGTGGTGGGGACCACCGAT CGTTCCGGTGTCCCTACGTATAGCTGGGGGGAGAATGAGACAGACGTGATGCTCCTCAAC AACACGCGTCCGCCACAAGGCAACTGGTTCGGCTGTACATGGATGAATAGTACTGGGTTC ACTAAGACGTGCGGAGGCCCCCCGTGTAACATCGGGGGGGTCGGTAACCGCACCTTGATC TGCCCCACGGACTGCTTCCGGAAGCACCCCGAGGCTACTTACACAAAATGTGGCTCGGGG CCCTGGTTGACACCTAGGTGCCTAGTAGACTACCCATACAGGCTCTGGCACTACCCCTGC ACTCTCAATTTTTCCATCTTTAAGGTTAGGATGTATGTGGGGGGCGTGGAGCACAGGCTC AATGCCGCATGCAATTGGACTCGAGGAGAGCGCTGTAACTTGGAGGACAGGGATAGGTCA GAACTCAGCCCGCTGCTGCTGTCTACAACAGAGTGGCAGATACTGCCCTGTGCCTTCACC ACCCTACCGGCTTTATCCACTGGTTTGATCCATCTCCATCAGAACATCGTGGACGTGCAA TACCTGTACGGTGTAGGGTCAGCGTTTGTCTCCTTTGCAATCAAATGGGAGTACATCCTG TTGCTTTTCCTTCTCCTGGCAGACGCGCGCGTGTGTGCCTGCTTGTGGATGATGCTGCTG ATAGCCCAGGCTGAGGCCGCCTTAGAGAACTTGGTGGTCCTCAATGCGGCGTCCGTGGCC GGAGCGCATGGTATTCTCTCCTTTCTTGTGTTCTTCTGCGCCGCCTGGTACATTAAGGGC AGGCTGGCTCCTGGGGCGGCGTATGCTTTTTATGGCGTATGGCCGCTGCTCCTGCTCCTA CTGGCGTTACCACCACGAGCTTACGCCTTGGACCGGGAGATGGCTGCATCGTGCGGGGGT GCGGTTCTTGTAGGTCTGGTATTCTTGACCTTGTCACCATACTACAAAGTGTTTCTCACT AGGCTCATATGGTGGTTACAATACTTTATCACCAGAGCCGAGGCGCACATGCAAGTGTGG GTCCCCCCCCTCAACGTTCGGGGAGGCCGCGATGCCATCATCCTCCTCACGTGTGCGGTT CATCCAGAGTTAATTTTTGACATCACCAAACTCCTGCTCGCCATACTCGGCCCGCTCATG GTGCTCCAGGCTGGCATAACGAGAGTGCCGTACTTCGTGCGCGCTCAAGGGCTCATTCGT GCATGCATGTTAGTGCGGAAAGTCGCCGGGGGTCATTATGTCCAAATGGCCTTCATGAAG CTGGGCGCGCTGACAGGTACGTACGTTTATAACCATCTTACCCCACTGCGGGACTGGGCC CACGCGGGCCTACGAGACCTTGCGGTGGCGGTAGAGCCCGTCGTCTTCTCCGCCATGGAG ACCAAGGTCATCACCTGGGGAGCAGACACCGCAGCATGTGGAGACATCATCTTGGGCCTA CCCGTCTCCGCCCGAAGGGGGAAGGAGATATTTTTGGGACCGGCTGATAGTCTCGAAGGG CAAGGGTGGCGACTCCTTGCGCCCATCACGGCCTACTCCCAACAAACGCGGGGCGTACTT GGTTGCATCATCACTAGCCTCACAGGCCGGGACAAGAACCAGGTCGAGGGGGAGGTTCAA GTGGTTTCTACCGCAACACAATCTTTCCTGGCGACCTGCATCAACGGCGTGTGCTGGACT GTCTACCATGGCGCTGGCTCGAAGACCCTAGCCGGTCCAAAAGGTCCAATCACCCAAATG TACACCAATGTAGACCTGGACCTCGTCGGCTGGCAGGCGCCCCCCGGGGCGCGCTCCATG ACACCATGCAGCTGTGGCAGCTCGGACCTTTACTTGGTCACGAGACATGCTGATGTCATT CCGGTGCGCCGGCGAGGCGACAGCAGGGGAAGTCTACTCTCCCCCAGGCCCGTCTCCTAC CTGAAGGGCTCCTCGGGTGGTCCATTGCTTTGCCCTTCGGGGCACGTCGTGGGCGTCTTC CGGGCTGCTGTGTGCACCCGGGGGGTCGCGAAGGCGGTGGACTTCATACCCGTTGAGTCT ATGGAAACTACCATGCGGTCTCCGGTCTTCACAGACAACTCATCCCCCCCGGCTGTACCG CAGACATTCCAAGTGGCACATCTGCACGCTCCTACTGGCAGCGGCAAGAGCACTAAAGTG CCGGCTGCGTATGCAGCCCAAGGGTACAAGGTGCTCGTCCTGAACCCGTCCGTTGCCGCC ACCTTAGGGTTTGGGGCGTATATGTCCAAGGCACACGGTATCGACCCTAACATCAGAACT GGGGTAAGGACCATTACCACGGGCGGCTCCATTACGTACTCCACCTATGGCAAGTTCCTT GCCGACGGTGGCTGCTCCGGGGGCGCCTATGACATCATAATATGTGATGAGTGCCACTCA ACTGACTCGACTACCATCTTGGGCATCGGCACAGTCCTGGACCAAGCGGAGACGGCTGGA GCGCGGCTTGTCGTGCTCGCCACCGCTACACCTCCGGGATCGGTTACCGTGCCACACCCC AATATCGAGGAAATAGGCCTGTCCAACAATGGAGAGATCCCCTTCTATGGCAAAGCCATC CCCATTGAGGCCATCAAGGGGGGGAGGCATCTCATTTTCTGCCATTCCAAGAAGAAATGT GACGAGCTCGCCGCAAAGCTGACAGGCCTCGGACTGAATGCTGTAGCATATTACCGGGGC CTTGATGTGTCCGTCATACCGCCTATCGGAGACGTCGTTGTCGTGGCAACAGACGCTCTA ATGACGGGTTTCACCGGCGATTTTGACTCAGTGATCGACTGCAACACATGTGTCACCCAG ACAGTCGACTTCAGCTTGGATCCCACCTTCACCATTGAGACGACGACCGTGCCCCAAGAC GCGGTGTCGCGCTCGCAACGGCGAGGTAGAACTGGCAGGGGTAGGAGTGGCATCTACAGG TTTGTGACTCCAGGAGAACGGCCCTCGGGCATGTTCGATTCTTCGGTCCTGTGTGAGTGC TATGACGCGGGCTGTGCTTGGTATGAGCTCACGCCCGCTGAGACCTCGGTTAGGTTGCGG GCTTACCTAAATACACCAGGGTTGCCCGTCTGCCAGGACCATCTGGAGTTCTGGGAGAGC GTCTTCACAGGCCTCACCCACATAGATGCCCACTTCCTGTCCCAGACTAAACAGGCAGGA GACAACTTTCCTTACCTGGTGGCATATCAAGCTACAGTATGCGCCAGGGCTCAAGCTCCA CCTCCATCGTGGGACCAAATGTGGAAGTGTCTCATACGGCTGAAACCTACACTGCACGGG CCAACACCCCTGCTGTATAGGCTAGGAGCCGTCCAAAATGAGGTCATCCTCACACACCCC ATAACTAAATACATCATGGCATGCATGTCGGCTGACCTGGAGGTCGTCACTAGCACCTGG GTGCTGGTAGGCGGAGTCCTTGCAGCTTTGGCCGCATATTGCCTGACGACAGGCAGTGTG GTCATTGTGGGCAGGATCATCTTGTCCGGGAAGCCAGCTGTCGTTCCCGACAGGGAAGTC CTCTACCAGGAGTTCGATGAGATGGAAGAGTGTGCCTCACAACTTCCTTACATCGAGCAG GGAATGCAGCTCGCCGAGCAATTTAAGCAAAAGGCGCTCGGGTTGTTGCAAACGGCCACC AAGCAAGCGGAGGCTGCTGCTCCCGTGGTGGAGTCCAAGTGGCGAGCCCTTGAGACCTTC TGGGCGAAGCACATGTGGAATTTCATCAGCGGGATACAGTACCTAGCAGGCTTATCCACT CTGCCTGGGAACCCCGCGATAGCATCATTGATGGCATTTACAGCTTCTATCACTAGCCCG CTCACCACCCAAAACACCCTCCTGTTTAACATCTTGGGGGGATGGGTGGCTGCCCAACTC GCTCCTCCCAGCGCTGCGTCAGCTTTCGTGGGCGCCGGCATCGCCGGAGCGGCTGTTGGC AGCATAGGCCTTGGGAAGGTGCTCGTGGACATCTTGGCGGGCTATGGGGCAGGGGTAGCC GGCGCACTCGTGGCCTTTAAGGTCATGAGCGGCGAGGTGCCCTCCACCGAGGACCTGGTC AACTTACTCCCTGCCATCCTCTCTCCTGGTGCCCTGGTCGTCGGGGTCGTGTGCGCAGCA ATACTGCGTCGGCACGTGGGCCCGGGAGAGGGGGCTGTGCAGTGGATGAACCGGCTGATA GCGTTCGCTTCGCGGGGTAACCACGTCTCCCCCACGCACTATGTGCCTGAGAGCGACGCT GCAGCACGTGTCACTCAGATCCTCTCTAGCCTTACCATCACTCAACTGCTGAAGCGGCTT CACCAGTGGATTAATGAGGACTGCTCTACGCCATGCTCCGGCTCGTGGCTAAGGGATGTT TGGGATTGGATATGCACGGTGTTGACTGACTTCAAGACCTGGCTCCAGTCCAAGCTCCTG CCGCGGTTACCGGGAGTCCCTTTCCTGTCATGCCAACGCGGGTACAAGGGAGTCTGGCGG GGGGACGGCATCATGCAAACCACCTGCCCATGTGGAGCACAGATCGCCGGACATGTCAAA AACGGTTCCATGAGGATCGTAGGGCCTAGAACCTGCAGCAACACGTGGCACGGAACGTTC CCCATCAACGCATACACCACGGGACCCTGCACACCCTCCCCGGCGCCCAACTATTCCAGG GCGCTATGGCGGGTGGCTGCTGAGGAGTACGTGGAGGTTACGCGTGTGGGAGATTTCCAC TACGTGACGGGCATGACCACTGACAACGTAAAGTGCCCATGCCAGGTTCCGGCCCCCGAA TTCTTCACGGAGGTGGATGGAGTGCGGTTGCACAGGTACGCTCCGGCGTGCAAACCTCTC CTACGGGAGGACGTCACGTTCCAGGTCGGGCTCAACCAATACTTGGTCGGGTCGCAGCTC CCATGCGAGCCCGAACCGGACGTAACAGTGCTTACTTCCATGCTCACCGATCCCTCCCAC ATTACAGCAGAGACGGCTAAGCGTAGGCTGGCTAGAGGGTCCCCCCCCTCTTTAGCCAGC TCATCAGCTAGCCAGTTGTCTGCGCCTTCTTTGAAGGCGACATGCACTACCCACCATGAC TCCCCGGACGCTGACCTCATCGAGGCCAACCTCTTGTGGCGGCAGGAGATGGGCGGAAAC ATCACTCGCGTGGAGTCAGAGAATAAGGTAGTAATTCTGGACTCTTTCGAACCGCTTCAC GCGGAGGGGGATGAGAGGGAGATATCCGTCGCGGCGGAGATCCTGCGAAAATCCAGGAAG TTCCCCTCAGCGTTGCCCATATGGGCACGCCCGGACTACAATCCTCCACTGCTAGAGTCC TGGAAGGACCCGGACTACGTCCCTCCGGTGGTACACGGATGCCCATTGCCACCTACCAAG GCTCCTCCAATACCACCTCCACGGAGAAAGAGGACGGTTGTCCTGACAGAATCCAATGTG TCTTCTGCCTTGGCGGAGCTCGCCACTAAGACCTTCGGTAGCTCCGGATCGTCGGCCGTT GATAGCGGCACGGCGACCGCCCTTCCTGACCTGGCCTCCGACGACGGTGACAAAGGGTCC GACGTTGAGTCGTACTCCTCCATGCCCCCCCTTGAAGGGGAGCCGGGGGACCCCGATCTC AGCGACGGGTCTTGGTCTACCGTGAGTGAGGAGGCTAGTGAGGACGTCGTCTGCTGCTCA ATGTCCTATACGTGGACAGGCGCCCTGATCACGCCATGCGCTGCGGAGGAAAGTAAGCTG CCCATCAACCCGTTGAGCAACTCTTTGCTGCGTCACCACAACATGGTCTACGCCACAACA TCCCGCAGCGCAAGCCTCCGGCAGAAGAAGGTCACCTTTGACAGATTGCAAGTCCTGGAT GACCATTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCTAAG CTTCTATCTATAGAGGAGGCCTGCAAGCTGACGCCCCCACATTCGGCCAAATCCAAATTT GGCTATGGGGCAAAGGACGTCCGGAACCTATCCAGCAGGGCCGTTAACCACATCCGCTCC GTGTGGGAGGACTTGCTGGAAGACACTGAAACACCAATTGACACCACCATCATGGCAAAA AGTGAGGTTTTCTGCGTCCAACCAGAGAAGGGAGGCCGCAAGCCAGCTCGCCTTATCGTA TTCCCAGACCTGGGAGTTCGTGTATGCGAGAAGATGGCCCTTTACGACGTGGTCTCCACC CTTCCTCAGGCCGTGATGGGCTCCTCATACGGATTTCAATACTCCCCCAAGCAGCGGGTC GAGTTCCTGGTGAATACCTGGAAATCAAAGAAATGCCCTATGGGCTTCTCATATGACACC CGCTGTTTTGACTCAACGGTCACTGAGAGTGACATTCGTGTTGAGGAGTCAATTTACCAA TGTTGTGACTTGGCCCCCGAGGCCAGACAGGCCATAAGGTCGCTCACGGAGCGGCTTTAC ATCGGGGGTCCCCTGACTAACTCAAAAGGGCAGAACTGCGGTTATCGCCGGTGCCGCGCA AGTGGCGTGCTGACGACTAGCTGCGGTAATACCCTCACATGTTACTTGAAGGCCACTGCG GCCTGTCGAGCTGCAAAGCTCCAGGACTGCACGATGCTCGTGAACGGAGACGACCTTGTC GTTATCTGTGAAAGCGCGGGAACCCAGGAGGATGCGGCGGCCCTACGAGCCTTCACGGAG GCTATGACTAGGTACTCCGCCCCCCCCGGGGATCCGCCCCAACCAGAATACGACCTGGAG CTGATAACATCATGTTCCTCCAATGTGTCAGTCGCGCACGATGCATCTGGCAAAAGGGTA TACTACCTCACCCGTGACCCCACCACCCCCCTTGCACGGGCTGCGTGGGAGACAGCTAGA CACACTCCAATCAACTCTTGGCTAGGCAATATCATCATGTATGCGCCCACCCTATGGGCA AGGATGATTCTGATGACTCACTTTTTCTCCATCCTTCTAGCTCAAGAGCAACTTGAAAAA GCCCTGGATTGTCAGATCTACGGGGCCTGCTACTCCATTGAGCCACTTGACCTACCTCAG ATCATTGAACGACTCCATGGTCTTAGCGCATTTACACTCCACAGTTACTCTCCAGGTGAG ATCAATAGGGTGGCTTCATGCCTCAGGAAACTTGGGGTACCACCCTTGCGAACCTGGAGA CATCGGGCCAGAAGTGTCCGCGCTAAGCTACTGTCCCAGGGGGGGAGGGCCGCCACTTGT GGCAGATACCTCTTTAACTGGGCAGTAAGGACCAAGCTTAAACTCACTCCAATCCCGGCT GCGTCCCAGCTGGACTTGTCCGGCTGGTTCGTCGCTGGTTACAGCGGGGGAGACATATAT CACAGCCTGTCTCGTGCCCGACCCCGCTGGTTTCCGTTGTGCCTACTCCTACTTTTTGTA GGGGTAGGCATTTACCTGCTCCCCAACCGATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O92972 UniProtKB Entry Name POLG_HCVJ4 GenBank Protein ID 221607 GenBank Gene ID D10750 - General References
- Okamoto H, Kojima M, Okada S, Yoshizawa H, Iizuka H, Tanaka T, Muchmore EE, Peterson DA, Ito Y, Mishiro S: Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology. 1992 Oct;190(2):894-9. [Article]
- Yanagi M, St Claire M, Shapiro M, Emerson SU, Purcell RH, Bukh J: Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo. Virology. 1998 Apr 25;244(1):161-72. [Article]
- Clarke D, Griffin S, Beales L, Gelais CS, Burgess S, Harris M, Rowlands D: Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro. J Biol Chem. 2006 Dec 1;281(48):37057-68. Epub 2006 Oct 10. [Article]
- Cramer J, Jaeger J, Restle T: Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4). Biochemistry. 2006 Mar 21;45(11):3610-9. [Article]
- Kim CS, Seol SK, Song OK, Park JH, Jang SK: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol. 2007 Apr;81(8):3852-65. Epub 2007 Jan 17. [Article]
- O'Farrell D, Trowbridge R, Rowlands D, Jager J: Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J Mol Biol. 2003 Feb 28;326(4):1025-35. [Article]