Monocarboxylate transporter 3
Details
- Name
- Monocarboxylate transporter 3
- Synonyms
- MCT 3
- MCT3
- Solute carrier family 16 member 8
- Gene Name
- SLC16A8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010110|Monocarboxylate transporter 3 MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWV SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTG LGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLL GGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRR RLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDI VARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMV GALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEV ALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALE VLSARGEPTEPEIEARPRLAAESV
- Number of residues
- 504
- Molecular Weight
- 52318.215
- Theoretical pI
- 5.32
- GO Classification
- Functionslactate transmembrane transporter activity / symporter activityProcessesblood coagulation / cellular metabolic process / lactate transport / leukocyte migration / plasma membrane lactate transport / pyruvate metabolic process / small molecule metabolic process / transmembrane transportComponentsbasal plasma membrane / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Symporter activity
- Specific Function
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 15-35 59-79 86-106 116-136 144-164 173-193 255-275 290-310 319-335 343-363 377-397 411-431
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010111|Monocarboxylate transporter 3 (SLC16A8) ATGGGCGCTGGCGGCCCCCGGCGGGGCGAGGGCCCCCCAGACGGCGGCTGGGGCTGGGTG GTGCTGGGCGCCTGCTTTGTGGTCACCGGCTTCGCCTACGGCTTCCCCAAAGCCGTGAGC GTCTTCTTCCGCGCGCTCATGCGCGACTTCGACGCCGGCTACAGCGACACGGCCTGGGTG TCCTCCATCATGCTAGCCATGCTCTACGGCACGGGCCCCGTGTCCAGCATCCTCGTGACC CGCTTTGGCTGTCGCCCGGTGATGCTGGCGGGTGGGCTGCTGGCTTCCGCGGGCATGATC CTAGCTTCCTTTGCCACGCGCCTCCTGGAGCTCTACCTGACCGCTGGGGTGCTCACAGGC CTGGGCCTGGCCCTCAACTTCCAGCCGTCGCTCATCATGCTGGGGCTGTACTTCGAGCGG CGGCGGCCTCTGGCCAACGGGCTGGCGGCGGCGGGCAGCCCCGTGTTCCTGTCCGCGCTG TCGCCGCTCGGCCAGCAGCTGCTGGAGCGCTTCGGCTGGCGCGGCGGCTTCCTGCTGCTC GGCGGGCTCCTGCTGCACTGCTGCGCCTGCGGGGCTGTCATGAGGCCGCCGCCCGGGCCG GGCCCGCGACCGCGCAGGGACAGCGCCGGCGACCGCGCCGGGGACGCTCCGGGCGAGGCG GAGGCTGACGGTGCGGGGCTGCAGCTGCGCGAGGCATCCCCCAGGGTCCGGCCCCGCCGG CGCCTGCTGGACTTGGCAGTGTGCACCGACCGCGCCTTCGCCGTGTACGCCGTCACCAAG TTCCTGATGGCGCTCGGGCTCTTCGTCCCCGCCATCCTGCTGGTGAACTACGCCAAGGAC GCGGGCGTGCCCGACACCGACGCCGCCTTCCTGCTGTCCATCGTGGGCTTCGTGGACATC GTGGCGCGCCCGGCGTGCGGCGCCCTGGCGGGCCTGGCGCGTCTGCGGCCGCACGTCCCG TATCTGTTCAGCCTGGCCCTGCTGGCCAATGGGCTCACAGACCTGAGCAGCGCACGCGCG CGCTCCTACGGCGCCCTCGTCGCCTTCTGCGTCGCCTTCGGCCTCTCCTACGGCATGGTG GGCGCGCTGCAGTTCGAGGTGCTCATGGCGGCTGTGGGCGCGCCCCGCTTCCCCAGTGCG CTGGGCCTGGTGTTGCTCGTGGAGGCCGCGGCTGTGCTCATCGGACCGCCCTCTGCCGGC CGCCTGGTGGATGTGTTGAAGAACTATGAGATCATCTTCTACCTGGCCGGCTCTGAGGTG GCCCTGGCTGGGGTCTTCATGGCTGTCGCCACCAACTGCTGCCTGCGTTGTGCTAAAGCT GCCCCGTCAGGCCCAGGCACTGAGGGCGGAGCCAGTGACACTGAGGACGCTGAGGCTGAA GGGGACTCTGAGCCCCTGCCTGTTGTTGCAGAGGAACCCGGCAACCTGGAGGCCCTGGAG GTGCTCAGCGCCCGGGGCGAGCCCACAGAACCAGAAATAGAGGCGAGGCCGAGGCTGGCT GCCGAGTCTGTATAA
- Chromosome Location
- 22
- Locus
- 22q12.3-q13.2
- External Identifiers
Resource Link UniProtKB ID O95907 UniProtKB Entry Name MOT3_HUMAN GenBank Protein ID 6103363 GenBank Gene ID AF132610 GenAtlas ID SLC16A8 HGNC ID HGNC:16270 - General References
- Yoon H, Donoso LA, Philp NJ: Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Genomics. 1999 Sep 15;60(3):366-70. [Article]
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]