Diphtheria toxin
Details
- Name
- Diphtheria toxin
- Synonyms
- DT
- NAD(+)--diphthamide ADP-ribosyltransferase
- Gene Name
- Not Available
- Organism
- Corynephage omega
- Amino acid sequence
>lcl|BSEQ0016402|Diphtheria toxin MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGI QKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALK VDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQ AKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKT KIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAG ANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIAL SSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYA VSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGR KIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQ KTVDHTKVNSKLSLFFEIKS
- Number of residues
- 560
- Molecular Weight
- 60814.155
- Theoretical pI
- 6.56
- GO Classification
- FunctionsNAD+-diphthamide ADP-ribosyltransferase activityProcessespathogenesisComponentsextracellular region
- General Function
- Nad+-diphthamide adp-ribosyltransferase activity
- Specific Function
- Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. Fragment A is responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002718|1683 bp GTGAGCAGAAAACTGTTTGCGTCAATCTTAATAGGGGCGCTACTGGGGATAGGGGCCCCA CCTTCAGCCCATGCAGGCGCTGATGATGTTGTTGATTCTTCTAAATCTTTTGTGATGGAA AACTTTTCTTCGTACCACGGGACTAAACCTGGTTATGTAGATTCCATTCAAAAAGGTATA CAAAAGCCAAAATCTGGTACACAAGGAAATTATGACGATGATTGGAAAGGGTTTTATAGT ACCGACAATAAATACGACGCTGCGGGATACTCTGTAGATAATGAAAACCCGCTCTCTGGA AAAGCTGGAGGCGTGGTCAAAGTGACGTATCCAGGACTGACGAAGGTTCTCGCACTAAAA GTGGATAATGCCGAAACTATTAAGAAAGAGTTAGGTTTAAGTCTCACTGAACCGTTGATG GAGCAAGTCGGAACGGAAGAGTTTATCAAAAGGTTCGGTGATGGTGCTTCGCGTGTAGTG CTCAGCCTTCCCTTCGCTGAGGGGAGTTCTAGCGTTGAATATATTAATAACTGGGAACAG GCGAAAGCGTTAAGCGTAGAACTTGAGATTAATTTTGAAACCCGTGGAAAACGTGGCCAA GATGCGATGTATGAGTATATGGCTCAAGCCTGTGCAGGAAATCGTGTCAGGCGATCAGTA GGTAGCTCATTGTCATGCATAAATCTTGATTGGGATGTCATAAGGGATAAAACTAAGACA AAGATAGAGTCTTTGAAAGAGCATGGCCCTATCAAAAATAAAATGAGCGAAAGTCCCAAT AAAACAGTATCTGAGGAAAAAGCTAAACAATACCTAGAAGAATTTCATCAAACGGCATTA GAGCATCCTGAATTGTCAGAACTTAAAACCGTTACTGGGACCAATCCTGTATTCGCTGGG GCTAACTATGCGGCGTGGGCAGTAAACGTTGCGCAAGTTATCGATAGCGAAACAGCTGAT AATTTGGAAAAGACAACTGCTGCTCTTTCGATACTTCCTGGTATCGGTAGCGTAATGGGC ATTGCAGACGGTGCCGTTCACCACAATACAGAAGAGATAGTGGCACAATCAATAGCTTTA TCGTCTTTAATGGTTGCTCAAGCTATTCCATTGGTAGGAGAGCTAGTTGATATTGGTTTC GCTGCATATAATTTTGTAGAGAGTATTATCAATTTATTTCAAGTAGTTCATAATTCGTAT AATCGTCCCGCGTATTCTCCGGGGCATAAAACGCAACCATTTCTTCATGACGGGTATGCT GTCAGTTGGAACACTGTTGAAGATTCGATAATCCGAACTGGTTTTCAAGGGGAGAGTGGG CACGACATAAAAATTACTGCTGAAAATACCCCGCTTCCAATCGCGGGTGTCCTACTACCG ACTATTCCTGGAAAGCTGGACGTTAATAAGTCCAAGACTCATATTTCCGTAAATGGTCGG AAAATAAGGATGCGTTGCAGAGCTATAGACGGTGATGTAACTTTTTGTCGCCCTAAATCT CCTGTTTATGTTGGTAATGGTGTGCATGCGAATCTTCACGTGGCATTTCACAGAAGCAGC TCGGAGAAAATTCATTCTAATGAAATTTCGTCGGATTCCATAGGCGTTCTTGGGTACCAG AAAACAGTAGATCACACCAAGGTTAATTCTAAGCTATCGCTATTTTTTGAAATCAAAAGC TGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P00587 UniProtKB Entry Name DTX_COROM GenBank Protein ID 579179 GenBank Gene ID V01536 - General References
- Ratti G, Rappuoli R, Giannini G: The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox+) genome. Nucleic Acids Res. 1983 Oct 11;11(19):6589-95. [Article]