ATP synthase subunit a


ATP synthase subunit a
  • ATP6
  • F-ATPase protein 6
  • MTATP6
Gene Name
Amino acid sequence
>lcl|BSEQ0049741|ATP synthase subunit a
Number of residues
Molecular Weight
Theoretical pI
Not Available
GO Classification
hydrogen ion transmembrane transporter activity / transmembrane transporter activity
aging / ATP biosynthetic process / mitochondrial ATP synthesis coupled proton transport / response to hyperoxia
extracellular exosome / integral component of membrane / mitochondrial inner membrane / mitochondrial proton-transporting ATP synthase complex / proton-transporting ATP synthase complex, coupling factor F(o)
General Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Specific Function
Hydrogen ion transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
6-26 68-88 97-117 138-158 164-184 189-209
Cellular Location
Mitochondrion inner membrane
Gene sequence
>lcl|BSEQ0049742|ATP synthase subunit a (MT-ATP6)
Chromosome Location
Not Available
Not Available
External Identifiers
UniProtKB IDP00846
UniProtKB Entry NameATP6_HUMAN
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00783Estradiolapproved, investigational, vet_approvedunknowninhibitorDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownDetails