Hemopexin
Details
- Name
- Hemopexin
- Synonyms
- Beta-1B-glycoprotein
- Gene Name
- HPX
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052381|Hemopexin MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATT LDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYP PEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKER SWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRN GTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ WPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSV DAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSA NGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH
- Number of residues
- 462
- Molecular Weight
- 51676.015
- Theoretical pI
- Not Available
- GO Classification
- Functionsheme transporter activity / metal ion bindingProcessescellular iron ion homeostasis / heme metabolic process / heme transport / hemoglobin metabolic process / positive regulation of humoral immune response mediated by circulating immunoglobulin / positive regulation of immunoglobulin production / positive regulation of interferon-gamma-mediated signaling pathway / positive regulation of tyrosine phosphorylation of STAT protein / receptor-mediated endocytosis / viral processComponentsblood microparticle / cell / collagen-containing extracellular matrix / endocytic vesicle lumen / extracellular exosome / extracellular region / extracellular space
- General Function
- Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
- Specific Function
- Heme transporter activity
- Pfam Domain Function
- Hemopexin (PF00045)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052382|Hemopexin (HPX) ATGGCTAGGGTACTGGGAGCACCCGTTGCACTGGGGTTGTGGAGCCTATGCTGGTCTCTG GCCATTGCCACCCCTCTTCCTCCGACTAGTGCCCATGGGAATGTTGCTGAAGGCGAGACC AAGCCAGACCCAGACGTGACTGAACGCTGCTCAGATGGCTGGAGCTTTGATGCTACCACC CTGGATGACAATGGAACCATGCTGTTTTTTAAAGGGGAGTTTGTGTGGAAGAGTCACAAA TGGGACCGGGAGTTAATCTCAGAGAGATGGAAGAATTTCCCCAGCCCTGTGGATGCTGCA TTCCGTCAAGGTCACAACAGTGTCTTTCTGATCAAGGGGGACAAAGTCTGGGTATACCCT CCTGAAAAGAAGGAGAAAGGATACCCAAAGTTGCTCCAAGATGAATTTCCTGGAATCCCA TCCCCACTGGATGCAGCTGTGGAATGTCACCGTGGAGAATGTCAAGCTGAAGGCGTCCTC TTCTTCCAAGGTGACCGCGAGTGGTTCTGGGACTTGGCTACGGGAACCATGAAGGAGCGT TCCTGGCCAGCTGTTGGGAACTGCTCCTCTGCCCTGAGATGGCTGGGCCGCTACTACTGC TTCCAGGGTAACCAATTCCTGCGCTTCGACCCTGTCAGGGGAGAGGTGCCTCCCAGGTAC CCGCGGGATGTCCGAGACTACTTCATGCCCTGCCCTGGCAGAGGCCATGGACACAGGAAT GGGACTGGCCATGGGAACAGTACCCACCATGGCCCTGAGTATATGCGCTGTAGCCCACAT CTAGTCTTGTCTGCACTGACGTCTGACAACCATGGTGCCACCTATGCCTTCAGTGGGACC CACTACTGGCGTCTGGACACCAGCCGGGATGGCTGGCATAGCTGGCCCATTGCTCATCAG TGGCCCCAGGGTCCTTCAGCAGTGGATGCTGCCTTTTCCTGGGAAGAAAAACTCTATCTG GTCCAGGGCACCCAGGTATATGTCTTCCTGACAAAGGGAGGCTATACCCTAGTAAGCGGT TATCCGAAGCGGCTGGAGAAGGAAGTCGGGACCCCTCATGGGATTATCCTGGACTCTGTG GATGCGGCCTTTATCTGCCCTGGGTCTTCTCGGCTCCATATCATGGCAGGACGGCGGCTG TGGTGGCTGGACCTGAAGTCAGGAGCCCAAGCCACGTGGACAGAGCTTCCTTGGCCCCAT GAGAAGGTAGACGGAGCCTTGTGTATGGAAAAGTCCCTTGGCCCTAACTCATGTTCCGCC AATGGTCCCGGCTTGTACCTCATCCATGGTCCCAATTTGTACTGCTACAGTGATGTGGAG AAACTGAATGCAGCCAAGGCCCTTCCGCAACCCCAGAATGTGACCAGTCTCCTGGGCTGC ACTCACTGA
- Chromosome Location
- 11
- Locus
- 11p15.4
- External Identifiers
Resource Link UniProtKB ID P02790 UniProtKB Entry Name HEMO_HUMAN HGNC ID HGNC:5171 - General References
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