Hemopexin

Details

Name
Hemopexin
Synonyms
  • Beta-1B-glycoprotein
Gene Name
HPX
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052381|Hemopexin
MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATT
LDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYP
PEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKER
SWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRN
GTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ
WPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSV
DAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSA
NGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH
Number of residues
462
Molecular Weight
51676.015
Theoretical pI
Not Available
GO Classification
Functions
heme transporter activity / metal ion binding
Processes
cellular iron ion homeostasis / heme metabolic process / heme transport / hemoglobin metabolic process / positive regulation of humoral immune response mediated by circulating immunoglobulin / positive regulation of immunoglobulin production / positive regulation of interferon-gamma-mediated signaling pathway / positive regulation of tyrosine phosphorylation of STAT protein / receptor-mediated endocytosis / viral process
Components
blood microparticle / cell / collagen-containing extracellular matrix / endocytic vesicle lumen / extracellular exosome / extracellular region / extracellular space
General Function
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
Specific Function
Heme transporter activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0052382|Hemopexin (HPX)
ATGGCTAGGGTACTGGGAGCACCCGTTGCACTGGGGTTGTGGAGCCTATGCTGGTCTCTG
GCCATTGCCACCCCTCTTCCTCCGACTAGTGCCCATGGGAATGTTGCTGAAGGCGAGACC
AAGCCAGACCCAGACGTGACTGAACGCTGCTCAGATGGCTGGAGCTTTGATGCTACCACC
CTGGATGACAATGGAACCATGCTGTTTTTTAAAGGGGAGTTTGTGTGGAAGAGTCACAAA
TGGGACCGGGAGTTAATCTCAGAGAGATGGAAGAATTTCCCCAGCCCTGTGGATGCTGCA
TTCCGTCAAGGTCACAACAGTGTCTTTCTGATCAAGGGGGACAAAGTCTGGGTATACCCT
CCTGAAAAGAAGGAGAAAGGATACCCAAAGTTGCTCCAAGATGAATTTCCTGGAATCCCA
TCCCCACTGGATGCAGCTGTGGAATGTCACCGTGGAGAATGTCAAGCTGAAGGCGTCCTC
TTCTTCCAAGGTGACCGCGAGTGGTTCTGGGACTTGGCTACGGGAACCATGAAGGAGCGT
TCCTGGCCAGCTGTTGGGAACTGCTCCTCTGCCCTGAGATGGCTGGGCCGCTACTACTGC
TTCCAGGGTAACCAATTCCTGCGCTTCGACCCTGTCAGGGGAGAGGTGCCTCCCAGGTAC
CCGCGGGATGTCCGAGACTACTTCATGCCCTGCCCTGGCAGAGGCCATGGACACAGGAAT
GGGACTGGCCATGGGAACAGTACCCACCATGGCCCTGAGTATATGCGCTGTAGCCCACAT
CTAGTCTTGTCTGCACTGACGTCTGACAACCATGGTGCCACCTATGCCTTCAGTGGGACC
CACTACTGGCGTCTGGACACCAGCCGGGATGGCTGGCATAGCTGGCCCATTGCTCATCAG
TGGCCCCAGGGTCCTTCAGCAGTGGATGCTGCCTTTTCCTGGGAAGAAAAACTCTATCTG
GTCCAGGGCACCCAGGTATATGTCTTCCTGACAAAGGGAGGCTATACCCTAGTAAGCGGT
TATCCGAAGCGGCTGGAGAAGGAAGTCGGGACCCCTCATGGGATTATCCTGGACTCTGTG
GATGCGGCCTTTATCTGCCCTGGGTCTTCTCGGCTCCATATCATGGCAGGACGGCGGCTG
TGGTGGCTGGACCTGAAGTCAGGAGCCCAAGCCACGTGGACAGAGCTTCCTTGGCCCCAT
GAGAAGGTAGACGGAGCCTTGTGTATGGAAAAGTCCCTTGGCCCTAACTCATGTTCCGCC
AATGGTCCCGGCTTGTACCTCATCCATGGTCCCAATTTGTACTGCTACAGTGATGTGGAG
AAACTGAATGCAGCCAAGGCCCTTCCGCAACCCCAGAATGTGACCAGTCTCCTGGGCTGC
ACTCACTGA
Chromosome Location
11
Locus
11p15.4
External Identifiers
ResourceLink
UniProtKB IDP02790
UniProtKB Entry NameHEMO_HUMAN
HGNC IDHGNC:5171
General References
  1. Altruda F, Poli V, Restagno G, Silengo L: Structure of the human hemopexin gene and evidence for intron-mediated evolution. J Mol Evol. 1988;27(2):102-8. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Law ML, Cai GY, Hartz JA, Jones C, Kao FT: The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11. Genomics. 1988 Jul;3(1):48-52. [Article]
  4. Altruda F, Poli V, Restagno G, Argos P, Cortese R, Silengo L: The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. Nucleic Acids Res. 1985 Jun 11;13(11):3841-59. [Article]
  5. Takahashi N, Takahashi Y, Putnam FW: Complete amino acid sequence of human hemopexin, the heme-binding protein of serum. Proc Natl Acad Sci U S A. 1985 Jan;82(1):73-7. [Article]
  6. Frantikova V, Borvak J, Kluh I, Moravek L: Amino acid sequence of the N-terminal region of human hemopexin. FEBS Lett. 1984 Dec 10;178(2):213-6. [Article]
  7. Takahashi N, Takahashi Y, Putnam FW: Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues. Proc Natl Acad Sci U S A. 1984 Apr;81(7):2021-5. [Article]
  8. Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A, Pandey A: A proteomic analysis of human bile. Mol Cell Proteomics. 2004 Jul;3(7):715-28. Epub 2004 Apr 14. [Article]
  9. Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wisniewski JR: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. Proteomics. 2004 Feb;4(2):454-65. [Article]
  10. Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [Article]
  11. Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J Proteome Res. 2006 Jun;5(6):1493-503. [Article]
  12. Ratra R, Kar-Roy A, Lal SK: The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II. Biochemistry. 2008 Feb 19;47(7):1957-69. doi: 10.1021/bi7016552. Epub 2008 Jan 23. [Article]
  13. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  14. Jia W, Lu Z, Fu Y, Wang HP, Wang LH, Chi H, Yuan ZF, Zheng ZB, Song LN, Han HH, Liang YM, Wang JL, Cai Y, Zhang YK, Deng YL, Ying WT, He SM, Qian XH: A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol Cell Proteomics. 2009 May;8(5):913-23. doi: 10.1074/mcp.M800504-MCP200. Epub 2009 Jan 12. [Article]
  15. Nilsson J, Ruetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G: Enrichment of glycopeptides for glycan structure and attachment site identification. Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18. [Article]
  16. Yang Z, Philips JD, Doty RT, Giraudi P, Ostrow JD, Tiribelli C, Smith A, Abkowitz JL: Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J Biol Chem. 2010 Sep 10;285(37):28874-82. doi: 10.1074/jbc.M110.119131. Epub 2010 Jul 7. [Article]
  17. Halim A, Ruetschi U, Larson G, Nilsson J: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. J Proteome Res. 2013 Feb 1;12(2):573-84. doi: 10.1021/pr300963h. Epub 2013 Jan 11. [Article]
  18. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14533Zinc chlorideapproved, investigationalunknownligandDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknownligandDetails
DB00080Daptomycinapproved, investigationalnobinderDetails