Fimbrial protein

Details

Name
Fimbrial protein
Synonyms
  • MS11 antigen
  • Pilin
Gene Name
pilE1
Organism
Neisseria gonorrhoeae
Amino acid sequence
>lcl|BSEQ0016532|Fimbrial protein
MNTLQKGFTLIELMIVIAIVGILAAVALPAYQDYTARAQVSEAILLAEGQKSAVTEYYLN
HGKWPENNTSAGVASPPSDIKGKYVKEVEVKNGVVTATMLSSGVNNEIKGKKLSLWARRE
NGSVKWFCGQPVTRTDDDTVADAKDGKEIDTKHLPSTCRDNFDAK
Number of residues
165
Molecular Weight
17944.29
Theoretical pI
7.4
GO Classification
Processes
cell adhesion
Components
pilus
General Function
Not Available
Specific Function
This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Fimbrium
Gene sequence
>lcl|BSEQ0003396|501 bp
ATGAATACCCTTCAAAAAGGCTTTACCCTTATCGAGCTGATGATTGTGATCGCTATCGTC
GGCATTTTGGCGGCAGTCGCCCTTCCCGCCTACCAAGACTACACCGCCCGCGCGCAAGTT
TCCGAAGCCATCCTTTTGGCCGAAGGTCAAAAATCAGCCGTCACCGAGTATTACCTGAAT
CACGGCAAATGGCCGGAAAACAACACTTCTGCCGGCGTGGCATCCCCCCCCTCCGACATC
AAAGGCAAATATGTTAAAGAGGTTGAAGTTAAAAACGGCGTCGTTACCGCCACAATGCTT
TCAAGCGGCGTAAACAATGAAATCAAAGGCAAAAAACTCTCCCTGTGGGCCAGGCGTGAA
AACGGTTCGGTAAAATGGTTCTGCGGACAGCCGGTTACGCGCACCGACGACGACACCGTT
GCCGACGCCAAAGACGGCAAAGAAATCGACACCAAGCACCTGCCGTCAACCTGCCGCGAT
AAGGCATCTGATGCCAAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP02974
UniProtKB Entry NameFMM1_NEIGO
GenBank Protein ID150288
GenBank Gene IDK02078
General References
  1. Meyer TF, Billyard E, Haas R, Storzbach S, So M: Pilus genes of Neisseria gonorrheae: chromosomal organization and DNA sequence. Proc Natl Acad Sci U S A. 1984 Oct;81(19):6110-4. [Article]
  2. Bergstrom S, Robbins K, Koomey JM, Swanson J: Piliation control mechanisms in Neisseria gonorrhoeae. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3890-4. [Article]
  3. Jonsson AB, Nyberg G, Normark S: Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly. EMBO J. 1991 Feb;10(2):477-88. [Article]
  4. Jonsson AB, Pfeifer J, Normark S: Neisseria gonorrhoeae PilC expression provides a selective mechanism for structural diversity of pili. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3204-8. [Article]
  5. Hermodson MA, Chen KC, Buchanan TM: Neisseria pili proteins: amino-terminal amino acid sequences and identification of an unusual amino acid. Biochemistry. 1978 Feb 7;17(3):442-5. [Article]
  6. Schoolnik GK, Fernandez R, Tai JY, Rothbard J, Gotschlich EC: Gonococcal pili. Primary structure and receptor binding domain. J Exp Med. 1984 May 1;159(5):1351-70. [Article]
  7. Hegge FT, Hitchen PG, Aas FE, Kristiansen H, Lovold C, Egge-Jacobsen W, Panico M, Leong WY, Bull V, Virji M, Morris HR, Dell A, Koomey M: Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10798-803. Epub 2004 Jul 12. [Article]
  8. Aas FE, Egge-Jacobsen W, Winther-Larsen HC, Lovold C, Hitchen PG, Dell A, Koomey M: Neisseria gonorrhoeae type IV pili undergo multisite, hierarchical modifications with phosphoethanolamine and phosphocholine requiring an enzyme structurally related to lipopolysaccharide phosphoethanolamine transferases. J Biol Chem. 2006 Sep 22;281(38):27712-23. Epub 2006 Jul 5. [Article]
  9. Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA: Structure of the fibre-forming protein pilin at 2.6 A resolution. Nature. 1995 Nov 2;378(6552):32-8. [Article]
  10. Forest KT, Dunham SA, Koomey M, Tainer JA: Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology. Mol Microbiol. 1999 Feb;31(3):743-52. [Article]
  11. Craig L, Volkmann N, Arvai AS, Pique ME, Yeager M, Egelman EH, Tainer JA: Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. Mol Cell. 2006 Sep 1;23(5):651-62. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04079Heptane-1,2,3-TriolexperimentalunknownDetails
DB04522DexfosfoserineexperimentalunknownDetails
DB06838methyl L-phenylalaninateexperimentalunknownDetails