Hexon protein
Details
- Name
- Hexon protein
- Synonyms
- CP-H
- Protein II
- Gene Name
- Not Available
- Organism
- HAdV-2
- Amino acid sequence
>lcl|BSEQ0019391|Hexon protein MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATETYFSLNNKFRNPTVAPTHDVTTDR SQRLTLRFIPVDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTA YNALAPKGAPNSCEWEQTEDSGRAVAEDEEEEDEDEEEEEEEQNARDQATKKTHVYAQAP LSGETITKSGLQIGSDNAETQAKPVYADPSYQPEPQIGESQWNEADANAAGGRVLKKTTP MKPCYGSYARPTNPFGGQSVLVPDEKGVPLPKVDLQFFSNTTSLNDRQGNATKPKVVLYS EDVNMETPDTHLSYKPGKGDENSKAMLGQQSMPNRPNYIAFRDNFIGLMYYNSTGNMGVL AGQASQLNAVVDLQDRNTELSYQLLLDSIGDRTRYFSMWNQAVDSYDPDVRIIENHGTED ELPNYCFPLGGIGVTDTYQAIKANGNGSGDNGDTTWTKDETFATRNEIGVGNNFAMEINL NANLWRNFLYSNIALYLPDKLKYNPTNVEISDNPNTYDYMNKRVVAPGLVDCYINLGARW SLDYMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWN FRKDVNMVLQSSLGNDLRVDGASIKFDSICLYATFFPMAHNTASTLEAMLRNDTNDQSFN DYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAFTRLKTKETPSLGSGYDPYYTYSGS IPYLDGTFYLNHTFKKVAITFDSSVSWPGNDRLLTPNEFEIKRSVDGEGYNVAQCNMTKD WFLVQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDDTKYKEYQQVGILHQHN NSGFVGYLAPTMREGQAYPANVPYPLIGKTAVDSITQKKFLCDRTLWRIPFSSNFMSMGA LTDLGQNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHQPHRGVIETVYLRTP FSAGNATT
- Number of residues
- 968
- Molecular Weight
- 109151.995
- Theoretical pI
- 4.84
- GO Classification
- Functionsstructural molecule activityProcessesmicrotubule-dependent intracellular transport of viral material towards nucleus / viral entry into host cellComponentshost cell nucleus / T=25 icosahedral viral capsid
- General Function
- Structural molecule activity
- Specific Function
- Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0006352|2907 bp ATGGCTACCCCTTCGATGATGCCGCAGTGGTCTTACATGCACATCTCGGGCCAGGACGCC TCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTTGCCCGCGCCACCGAGACGTACTTCAGC CTGAATAACAAGTTTAGAAACCCCACGGTGGCACCTACGCACGACGTAACCACAGACCGG TCCCAGCGTTTGACGCTGCGGTTCATCCCTGTGGACCGCGAGGATACCGCGTACTCGTAC AAAGCGCGGTTCACCCTGGCTGTGGGTGACAACCGTGTGCTTGATATGGCTTCCACGTAC TTTGACATCCGCGGCGTGCTGGACAGGGGGCCTACTTTTAAGCCCTACTCCGGCACTGCC TACAACGCTCTAGCTCCCAAGGGCGCTCCTAACTCCTGTGAGTGGGAACAAACCGAAGAT AGCGGCCGGGCAGTTGCCGAGGATGAAGAAGAGGAAGATGAAGATGAAGAAGAGGAAGAA GAAGAGCAAAACGCTCGAGATCAGGCTACTAAGAAAACACATGTCTATGCCCAGGCTCCT TTGTCTGGAGAAACAATTACAAAAAGCGGGCTACAAATAGGATCAGACAATGCAGAAACA CAAGCTAAACCTGTATACGCAGATCCTTCCTATCAACCAGAACCTCAAATTGGCGAATCT CAGTGGAACGAAGCTGATGCTAATGCGGCAGGAGGGAGAGTGCTTAAAAAAACAACTCCC ATGAAACCATGCTATGGATCTTATGCCAGGCCTACAAATCCTTTTGGTGGTCAATCCGTT CTGGTTCCGGATGAAAAAGGGGTGCCTCTTCCAAAGGTTGACTTGCAATTCTTCTCAAAT ACTACCTCTTTGAACGACCGGCAAGGCAATGCTACTAAACCAAAAGTGGTTTTGTACAGT GAAGATGTAAATATGGAAACCCCAGACACACATCTGTCTTACAAACCTGGAAAAGGTGAT GAAAATTCTAAAGCTATGTTGGGTCAACAATCTATGCCAAACAGACCCAATTACATTGCT TTCAGGGACAATTTTATTGGCCTAATGTATTATAACAGCACTGGCAACATGGGTGTTCTT GCTGGTCAGGCATCGCAGCTAAATGCCGTGGTAGATTTGCAAGACAGAAACACAGAGCTG TCCTATCAACTCTTGCTTGATTCCATAGGTGATAGAACCAGATATTTTTCTATGTGGAAT CAGGCTGTAGACAGCTATGATCCAGATGTTAGAATCATTGAAAACCATGGAACTGAGGAT GAATTGCCAAATTATTGTTTTCCTCTTGGGGGTATTGGGGTAACTGACACCTATCAAGCT ATTAAGGCTAATGGCAATGGCTCAGGCGATAATGGAGATACTACATGGACAAAAGATGAA ACTTTTGCAACACGTAATGAAATAGGAGTGGGTAACAACTTTGCCATGGAAATTAACCTA AATGCCAACCTATGGAGAAATTTCCTTTACTCCAATATTGCGCTGTACCTGCCAGACAAG CTAAAATACAACCCCACCAATGTGGAAATATCTGACAACCCCAACACCTACGACTACATG AACAAGCGAGTGGTGGCTCCCGGGCTTGTAGACTGCTACATTAACCTTGGGGCGCGCTGG TCTCTGGACTACATGGACAACGTTAATCCCTTTAACCACCACCGCAATGCGGGCCTCCGT TATCGCTCCATGTTGTTGGGAAACGGCCGCTACGTGCCCTTTCACATTCAGGTGCCCCAA AAGTTTTTTGCCATTAAAAACCTCCTCCTCCTGCCAGGCTCATATACATATGAATGGAAC TTCAGGAAGGATGTTAACATGGTTCTGCAGAGCTCTCTGGGAAACGATCTTAGAGTTGAC GGGGCTAGCATTAAGTTTGACAGCATTTGTCTTTACGCCACCTTCTTCCCCATGGCCCAC AACACGGCCTCCACGCTGGAAGCCATGCTCAGAAATGACACCAACGACCAGTCCTTTAAT GACTACCTTTCCGCCGCCAACATGCTATACCCCATACCCGCCAACGCCACCAACGTGCCC ATCTCCATCCCATCGCGCAACTGGGCAGCATTTCGCGGTTGGGCCTTCACACGCTTGAAG ACAAAGGAAACCCCTTCCCTGGGATCAGGCTACGACCCTTACTACACCTACTCTGGCTCC ATACCATACCTTGACGGAACCTTCTATCTTAATCACACCTTTAAGAAGGTGGCCATTACC TTTGACTCTTCTGTTAGCTGGCCGGGCAACGACCGCCTGCTTACTCCCAATGAGTTTGAG ATTAAACGCTCAGTTGACGGGGAGGGCTACAACGTAGCTCAGTGCAACATGACCAAGGAC TGGTTCCTGGTGCAGATGTTGGCCAACTACAATATTGGCTACCAGGGCTTCTACATTCCA GAAAGCTACAAGGACCGCATGTACTCGTTCTTCAGAAACTTCCAGCCCATGAGCCGGCAA GTGGTTGACGATACTAAATACAAGGAGTATCAGCAGGTTGGAATTCTTCACCAGCATAAC AACTCAGGATTCGTAGGCTACCTCGCTCCCACCATGCGCGAGGGACAGGCTTACCCCGCC AACGTGCCCTACCCACTAATAGGCAAAACCGCGGTTGACAGTATTACCCAGAAAAAGTTT CTTTGCGATCGCACCCTTTGGCGCATCCCATTCTCCAGTAACTTTATGTCCATGGGCGCA CTCACAGACCTGGGCCAAAACCTTCTCTACGCCAACTCCGCCCACGCGCTAGACATGACT TTTGAGGTGGATCCCATGGACGAGCCCACCCTTCTTTATGTTTTGTTTGAAGTCTTTGAC GTGGTCCGTGTGCACCAGCCGCACCGCGGCGTCATCGAGACCGTGTACCTGCGCACGCCC TTCTCGGCCGGCAACGCCACAACATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P03277 UniProtKB Entry Name CAPSH_ADE02 GenBank Gene ID J01917 - General References
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- Jornvall H, Akusjarvi G, Alestrom P, von Bahr-Lindstrom H, Pettersson U, Appella E, Fowler AV, Philipson L: The adenovirus hexon protein. The primary structure of the polypeptide and its correlation with the hexon gene. J Biol Chem. 1981 Jun 25;256(12):6181-6. [Article]
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- Akusjarvi G, Zabielski J, Perricaudet M, Pettersson U: The sequence of the 3' non-coding region of the hexon mRNA discloses a novel adenovirus gene. Nucleic Acids Res. 1981 Jan 10;9(1):1-17. [Article]
- Cepko CL, Sharp PA: Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 1982 Dec;31(2 Pt 1):407-15. [Article]
- Jornvall H, Ohlsson H, Philipson L: An acetylated N-terminus of adenovirus type 2 hexon protein. Biochem Biophys Res Commun. 1974 Jan 23;56(2):304-10. [Article]
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- Wodrich H, Guan T, Cingolani G, Von Seggern D, Nemerow G, Gerace L: Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals. EMBO J. 2003 Dec 1;22(23):6245-55. [Article]
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- Bremner KH, Scherer J, Yi J, Vershinin M, Gross SP, Vallee RB: Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe. 2009 Dec 17;6(6):523-35. doi: 10.1016/j.chom.2009.11.006. [Article]
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- Athappilly FK, Murali R, Rux JJ, Cai Z, Burnett RM: The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 A resolution. J Mol Biol. 1994 Sep 30;242(4):430-55. [Article]