Regulatory protein E2
Details
- Name
- Regulatory protein E2
- Synonyms
- Not Available
- Gene Name
- E2
- Organism
- Human papillomavirus type 11
- Amino acid sequence
>lcl|BSEQ0011202|Regulatory protein E2 MEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVP PLTVSETKGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYEMWLTPPKRCFKKQGNTVEVK FDGCEDNVMEYVVWTHIYLQDNDSWVKVTSSVDAKGIYYTCGQFKTYYVNFNKEAQKYGS TNHWEVCYGSTVICSPASVSSTVREVSIAEPTTYTPAQTTAPTVSACTTEDGVSAPPRKR ARGPSTNNTLCVANIRSVDSTINNIVTDNYNKHQRRNNCHSAATPIVQLQGDSNCLKCFR YRLNDKYKHLFELASSTWHWASPEAPHKNAIVTLTYSSEEQRQQFLNSVKIPPTIRHKVG FMSLHLL
- Number of residues
- 367
- Molecular Weight
- 41709.06
- Theoretical pI
- 7.89
- GO Classification
- FunctionsDNA binding / nucleotide binding / transcription factor activity, sequence-specific DNA bindingProcessesregulation of DNA replication / transcription, DNA-templated / viral DNA genome replicationComponentshost cell nucleus
- General Function
- Transcription factor activity, sequence-specific dna binding
- Specific Function
- Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Host nucleus
- Gene sequence
>lcl|BSEQ0003341|1104 bp ATGGAAGCAATAGCCAAGCGTTTAGATGCGTGCCAGGATCAGTTGTTAGAACTTTATGAA GAAAACAGTATTGATATACACAAACACATTATGCATTGGAAATGCATACGATTGGAAAGT GTATTACTACACAAAGCAAAACAAATGGGCCTGAGCCACATCGGGTTACAAGTAGTACCA CCATTAACTGTGTCAGAGACTAAAGGACATAATGCTATTGAAATGCAAATGCATTTAGAA TCCTTAGCAAAAACTCAGTATGGTGTGGAACCTTGGACATTACAGGACACCAGTTATGAA ATGTGGCTAACACCACCCAAACGGTGCTTTAAAAAACAGGGAAATACTGTGGAGGTAAAA TTTGATGGCTGTGAAGACAATGTAATGGAGTATGTGGTATGGACACATATATACCTGCAG GACAACGACTCATGGGTAAAAGTAACTAGTTCCGTAGATGCCAAGGGCATATATTATACA TGTGGACAATTTAAAACATATTATGTAAATTTTAATAAAGAGGCACAAAAGTATGGTAGT ACCAATCATTGGGAAGTATGTTATGGCAGCACAGTTATATGTTCTCCTGCATCTGTATCT AGCACTGTACGAGAAGTATCCATTGCTGAACCTACTACATACACCCCCGCACAGACCACC GCCCCTACAGTGTCCGCCTGCACCACGGAAGACGGCGTGTCGGCGCCGCCTAGGAAGCGA GCACGTGGACCGTCCACTAACAACACCCTGTGTGTGGCCAACATCAGATCCGTGGACAGT ACAATCAACAACATCGTCACTGACAATTACAACAAGCACCAAAGAAGGAACAACTGTCAC AGTGCAGCTACGCCTATAGTGCAACTGCAAGGTGATTCCAATTGTTTAAAATGTTTTAGA TATAGACTGAATGACAAATATAAACATTTGTTTGAATTAGCATCTTCAACGTGGCATTGG GCCTCACCTGAGGCACCACATAAAAATGCAATTGTAACATTAACATATAGCAGTGAGGAA CAACGTCAGCAATTTTTAAACAGTGTAAAAATACCACCCACCATTAGGCATAAGGTGGGG TTTATGTCATTACATTTATTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P04015 UniProtKB Entry Name VE2_HPV11 GenBank Protein ID 496195 GenBank Gene ID M14119 - General References
- Dartmann K, Schwarz E, Gissmann L, zur Hausen H: The nucleotide sequence and genome organization of human papilloma virus type 11. Virology. 1986 May;151(1):124-30. [Article]