Cytochrome P450 2B2

Details

Name
Cytochrome P450 2B2
Synonyms
  • 1.14.14.1
  • Cyp2b-2
  • CYPIIB2
  • Cytochrome P450 PB4
  • Cytochrome P450E
Gene Name
Cyp2b2
Organism
Rat
Amino acid sequence
>lcl|BSEQ0008614|Cytochrome P450 2B2
MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLRE
KYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGER
WKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIIC
SIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQE
ILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGT
ETGSTTLRYGFLLMLKYPHVTEKVQKEIDQVIGSHRPPSLDDRTKMPYTDAVIHEIQRFA
DLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDTFNPEHFLDADGTL
KKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIAKI
PPTYQICFSAR
Number of residues
491
Molecular Weight
55932.02
Theoretical pI
Not Available
GO Classification
Functions
arachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activity
Processes
aging / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / nicotine metabolic process / oxidation-reduction process / response to calcium ion / response to metal ion / response to organic cyclic compound / xenobiotic metabolic process
Components
cytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0013306|Cytochrome P450 2B2 (Cyp2b2)
ATGGAGCCCAGTATCTTGCTCCTCCTTGCTCTCCTTGTGGGCTTCTTGTTACTCTTAGTC
AGGGGACACCCAAAGTCCCGTGGCAACTTCCCACCAGGACCTCGTCCCCTTCCCCTCTTG
GGGAACCTCCTGCAGTTGGACAGAGGAGGCCTCCTCAATTCCTTCATGCAGTTTCGCGAA
AAATATGGAGATGTGTTCACAGTACACCTGGGACCAAGGCCTGTGGTCATGCTATGTGGG
ACAGACACCATAAAGGAGGCTCTGGTGGGCCAAGCTGAAGATTTCTCTGGTCGGGGAACA
ATCGCTGTGATTGAGCCAATCTTCAAGGAATATGGTGTGTTCTTTGCCAATGGGGAACGC
TGGAAGGCCCTTCGGCGATTCTCTCTGGCTACCATGAGAGACTTTGGGATGGGAAAGAGG
AGTGTGGAAGAACGGATTCAGGAGGAAGCCCAATGTTTGGTGGAGGAACTGCGGAAATCC
CAGGGAGCCCCACTGGATCCCACCTTCCTCTTCCAGTGCATCACAGCCAACATCATCTGC
TCCATTGTGTTTGGAGAGCGCTTTGACTACACAGACCGCCAGTTCCTGCGCCTGTTGGAG
CTGTTCTACCGGACCTTTTCCCTCCTAAGTTCATTCTCCAGCCAGGTGTTTGAGTTCTTC
TCTGGGTTCCTGAAATACTTTCCTGGTGCCCACAGACAAATCTCCAAAAACCTCCAGGAA
ATCCTCGATTACATTGGCCATATTGTGGAGAAGCACAGGGCCACCTTAGACCCCAGCGCT
CCACGAGACTTCATCGACACTTACCTTCTGCGCATGGAGAAAGTGAGTCCTGCATGGATG
AGAGAGGAGAAGTCGAACCACCACACAGAGTTCCATCATGAGAACCTCATGATCTCCCTG
CTCTCTCTCTTCTTTGCTGGCACTGAGACCGGCAGCACCACACTCCGCTATGGTTTCCTG
CTCATGCTCAAGTACCCCCATGTCACAGAGAAAGTCCAAAAGGAGATTGATCAGGTGATT
GGCTCTCACAGGCCACCATCCCTTGATGATCGTACCAAAATGCCATACACTGATGCAGTC
ATCCACGAGATTCAGAGATTTGCAGATCTTGCCCCAATTGGTTTACCACACAGAGTCACC
AAAGACACCATGTTCCGAGGGTACCTGCTCCCCAAGAACACTGAGGTGTATCCCATCCTG
AGTTCAGCTCTCCATGACCCACAGTACTTTGACCATCCAGACACCTTCAATCCTGAGCAC
TTCCTGGATGCCGATGGGACACTGAAAAAGAGTGAAGCTTTTATGCCCTTCTCCACAGGA
AAGCGCATTTGTCTTGGCGAAGGCATTGCCCGAAATGAATTGTTCCTCTTCTTCACCACC
ATCCTCCAGAACTTCTCTGTGTCAAGCCATTTGGCTCCCAAGGACATTGACCTCACGCCC
AAGGAGAGTGGCATTGCAAAAATACCTCCAACATACCAGATCTGCTTCTCAGCTCGGTGA
Chromosome Location
1
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP04167
UniProtKB Entry NameCP2B2_RAT
General References
  1. Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y: Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver. Proc Natl Acad Sci U S A. 1983 Jul;80(13):3958-62. [Article]
  2. Frey AB, Waxman DJ, Kreibich G: The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies. J Biol Chem. 1985 Dec 5;260(28):15253-65. [Article]
  3. Lacroix D, Desrochers M, Lambert M, Anderson A: Alternative splicing of mRNA encoding rat liver cytochrome P450e (P450IIB2). Gene. 1990 Feb 14;86(2):201-7. [Article]
  4. Phillips IR, Shephard EA, Ashworth A, Rabin BR: Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics. Gene. 1983 Dec;26(1):41-52. [Article]
  5. Kumar A, Raphael C, Adesnik M: Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species. J Biol Chem. 1983 Sep 25;258(18):11280-4. [Article]
  6. Atchison M, Adesnik M: Gene conversion in a cytochrome P-450 gene family. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2300-4. [Article]
  7. Oesch F, Waxman DJ, Morrissey JJ, Honscha W, Kissel W, Friedberg T: Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. Arch Biochem Biophys. 1989 Apr;270(1):23-32. [Article]
  8. Affolter M, Anderson A: Segmental homologies in the coding and 3' non-coding sequences of rat liver cytochrome P-450e and P-450b cDNAs and cytochrome P-450e-like genes. Biochem Biophys Res Commun. 1984 Jan 30;118(2):655-62. [Article]
  9. Hashimoto T, Matsumoto T, Nishizawa M, Kawabata S, Morohashi K, Handa S, Omura T: A mutant rat strain deficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes. J Biochem. 1988 Mar;103(3):487-92. [Article]
  10. Amelizad Z, Narbonne JF, Wolf CR, Robertson LW, Oesch F: Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver. Biochem Pharmacol. 1988 Sep 1;37(17):3245-9. [Article]
  11. Pyerin W, Taniguchi H: Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450. EMBO J. 1989 Oct;8(10):3003-10. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails