Cytochrome P450 2B2
Details
- Name
- Cytochrome P450 2B2
- Synonyms
- 1.14.14.1
- Cyp2b-2
- CYPIIB2
- Cytochrome P450 PB4
- Cytochrome P450E
- Gene Name
- Cyp2b2
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0008614|Cytochrome P450 2B2 MEPSILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLRE KYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGER WKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIIC SIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQE ILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGT ETGSTTLRYGFLLMLKYPHVTEKVQKEIDQVIGSHRPPSLDDRTKMPYTDAVIHEIQRFA DLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDTFNPEHFLDADGTL KKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIAKI PPTYQICFSAR
- Number of residues
- 491
- Molecular Weight
- 55932.02
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessesaging / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / nicotine metabolic process / oxidation-reduction process / response to calcium ion / response to metal ion / response to organic cyclic compound / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0013306|Cytochrome P450 2B2 (Cyp2b2) ATGGAGCCCAGTATCTTGCTCCTCCTTGCTCTCCTTGTGGGCTTCTTGTTACTCTTAGTC AGGGGACACCCAAAGTCCCGTGGCAACTTCCCACCAGGACCTCGTCCCCTTCCCCTCTTG GGGAACCTCCTGCAGTTGGACAGAGGAGGCCTCCTCAATTCCTTCATGCAGTTTCGCGAA AAATATGGAGATGTGTTCACAGTACACCTGGGACCAAGGCCTGTGGTCATGCTATGTGGG ACAGACACCATAAAGGAGGCTCTGGTGGGCCAAGCTGAAGATTTCTCTGGTCGGGGAACA ATCGCTGTGATTGAGCCAATCTTCAAGGAATATGGTGTGTTCTTTGCCAATGGGGAACGC TGGAAGGCCCTTCGGCGATTCTCTCTGGCTACCATGAGAGACTTTGGGATGGGAAAGAGG AGTGTGGAAGAACGGATTCAGGAGGAAGCCCAATGTTTGGTGGAGGAACTGCGGAAATCC CAGGGAGCCCCACTGGATCCCACCTTCCTCTTCCAGTGCATCACAGCCAACATCATCTGC TCCATTGTGTTTGGAGAGCGCTTTGACTACACAGACCGCCAGTTCCTGCGCCTGTTGGAG CTGTTCTACCGGACCTTTTCCCTCCTAAGTTCATTCTCCAGCCAGGTGTTTGAGTTCTTC TCTGGGTTCCTGAAATACTTTCCTGGTGCCCACAGACAAATCTCCAAAAACCTCCAGGAA ATCCTCGATTACATTGGCCATATTGTGGAGAAGCACAGGGCCACCTTAGACCCCAGCGCT CCACGAGACTTCATCGACACTTACCTTCTGCGCATGGAGAAAGTGAGTCCTGCATGGATG AGAGAGGAGAAGTCGAACCACCACACAGAGTTCCATCATGAGAACCTCATGATCTCCCTG CTCTCTCTCTTCTTTGCTGGCACTGAGACCGGCAGCACCACACTCCGCTATGGTTTCCTG CTCATGCTCAAGTACCCCCATGTCACAGAGAAAGTCCAAAAGGAGATTGATCAGGTGATT GGCTCTCACAGGCCACCATCCCTTGATGATCGTACCAAAATGCCATACACTGATGCAGTC ATCCACGAGATTCAGAGATTTGCAGATCTTGCCCCAATTGGTTTACCACACAGAGTCACC AAAGACACCATGTTCCGAGGGTACCTGCTCCCCAAGAACACTGAGGTGTATCCCATCCTG AGTTCAGCTCTCCATGACCCACAGTACTTTGACCATCCAGACACCTTCAATCCTGAGCAC TTCCTGGATGCCGATGGGACACTGAAAAAGAGTGAAGCTTTTATGCCCTTCTCCACAGGA AAGCGCATTTGTCTTGGCGAAGGCATTGCCCGAAATGAATTGTTCCTCTTCTTCACCACC ATCCTCCAGAACTTCTCTGTGTCAAGCCATTTGGCTCCCAAGGACATTGACCTCACGCCC AAGGAGAGTGGCATTGCAAAAATACCTCCAACATACCAGATCTGCTTCTCAGCTCGGTGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P04167 UniProtKB Entry Name CP2B2_RAT - General References
- Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y: Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver. Proc Natl Acad Sci U S A. 1983 Jul;80(13):3958-62. [Article]
- Frey AB, Waxman DJ, Kreibich G: The structure of phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4. Production and characterization of site-specific antibodies. J Biol Chem. 1985 Dec 5;260(28):15253-65. [Article]
- Lacroix D, Desrochers M, Lambert M, Anderson A: Alternative splicing of mRNA encoding rat liver cytochrome P450e (P450IIB2). Gene. 1990 Feb 14;86(2):201-7. [Article]
- Phillips IR, Shephard EA, Ashworth A, Rabin BR: Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics. Gene. 1983 Dec;26(1):41-52. [Article]
- Kumar A, Raphael C, Adesnik M: Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species. J Biol Chem. 1983 Sep 25;258(18):11280-4. [Article]
- Atchison M, Adesnik M: Gene conversion in a cytochrome P-450 gene family. Proc Natl Acad Sci U S A. 1986 Apr;83(8):2300-4. [Article]
- Oesch F, Waxman DJ, Morrissey JJ, Honscha W, Kissel W, Friedberg T: Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. Arch Biochem Biophys. 1989 Apr;270(1):23-32. [Article]
- Affolter M, Anderson A: Segmental homologies in the coding and 3' non-coding sequences of rat liver cytochrome P-450e and P-450b cDNAs and cytochrome P-450e-like genes. Biochem Biophys Res Commun. 1984 Jan 30;118(2):655-62. [Article]
- Hashimoto T, Matsumoto T, Nishizawa M, Kawabata S, Morohashi K, Handa S, Omura T: A mutant rat strain deficient in induction of a phenobarbital-inducible form of cytochrome P-450 in liver microsomes. J Biochem. 1988 Mar;103(3):487-92. [Article]
- Amelizad Z, Narbonne JF, Wolf CR, Robertson LW, Oesch F: Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver. Biochem Pharmacol. 1988 Sep 1;37(17):3245-9. [Article]
- Pyerin W, Taniguchi H: Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450. EMBO J. 1989 Oct;8(10):3003-10. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details