Cholesterol side-chain cleavage enzyme, mitochondrial
Details
- Name
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Synonyms
- 1.14.15.6
- Cholesterol desmolase
- CYP11A
- CYPXIA1
- Cytochrome P450 11A1
- Cytochrome P450(scc)
- Gene Name
- CYP11A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006815|Cholesterol side-chain cleavage enzyme, mitochondrial MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
- Number of residues
- 521
- Molecular Weight
- 60101.87
- Theoretical pI
- 9.18
- GO Classification
- Functionscholesterol binding / cholesterol monooxygenase (side-chain-cleaving) activity / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenProcessesbiphenyl metabolic process / C21-steroid hormone biosynthetic process / cellular response to antibiotic / cellular response to cadmium ion / cellular response to cAMP / cellular response to fibroblast growth factor stimulus / cellular response to follicle-stimulating hormone stimulus / cellular response to interleukin-1 / cellular response to lipopolysaccharide / cellular response to peptide hormone stimulus / cellular response to transforming growth factor beta stimulus / cellular response to tumor necrosis factor / cerebellum development / cholesterol metabolic process / cortisol metabolic process / dibenzo-p-dioxin metabolic process / estrogen biosynthetic process / glucocorticoid biosynthetic process / granulosa cell differentiation / hippocampus development / Leydig cell differentiation / maternal process involved in female pregnancy / mating behavior / oxidation-reduction process / phenol-containing compound metabolic process / phthalate metabolic process / progesterone biosynthetic process / response to alkaloid / response to amino acid / response to corticosterone / response to drug / response to fungicide / response to gamma radiation / response to genistein / response to hydrogen peroxide / response to insecticide / response to L-ascorbic acid / response to salt stress / response to vitamin E / Schwann cell differentiation / secondary metabolite biosynthetic process / small molecule metabolic process / steroid metabolic process / sterol metabolic process / testosterone biosynthetic process / vitamin D metabolic process / xenobiotic metabolic processComponentsmitochondrial crista / mitochondrial inner membrane / mitochondrial matrix / mitochondrion / perikaryon
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
- Specific Function
- Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion membrane
- Gene sequence
>lcl|BSEQ0012463|Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTGCCAGACCTTTCTG AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC ATCCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG CAGTGA
- Chromosome Location
- 15
- Locus
- 15q23-q24
- External Identifiers
Resource Link UniProtKB ID P05108 UniProtKB Entry Name CP11A_HUMAN GenBank Protein ID 181376 GenBank Gene ID M14565 HGNC ID HGNC:2590 - General References
- Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL: Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proc Natl Acad Sci U S A. 1986 Dec;83(23):8962-6. [Article]
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- Hu MC, Guo IC, Lin JH, Chung BC: Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. Biochem J. 1991 Mar 15;274 ( Pt 3):813-7. [Article]
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- Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW: Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10139-43. doi: 10.1073/pnas.1019441108. Epub 2011 Jun 2. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00169 Cholecalciferol approved, nutraceutical unknown substrate Details DB00390 Digoxin approved unknown inhibitor Details DB00624 Testosterone approved, investigational unknown inhibitor Details DB01396 Digitoxin approved, investigational unknown inhibitor Details DB00357 Aminoglutethimide approved, investigational yes inhibitor Details DB02901 Stanolone illicit, investigational unknown substrate Details DB01437 Glutethimide approved, illicit unknown inhibitor Details DB13943 Testosterone cypionate approved unknown inhibitor Details DB13944 Testosterone enanthate approved unknown inhibitor Details DB13946 Testosterone undecanoate approved, investigational unknown inhibitor Details DB00153 Ergocalciferol approved, nutraceutical no substrate Details DB05667 Levoketoconazole approved, investigational yes inhibitor Details