Cytochrome P450 3A2

Details

Name
Cytochrome P450 3A2
Synonyms
  • 1.14.14.1
  • Cyp3a-2
  • Cyp3a11
  • CYPIIIA2
  • Cytochrome P450-PCN2
  • Cytochrome P450/6-beta-A
  • Testosterone 6-beta-hydroxylase
Gene Name
Cyp3a2
Organism
Rat
Amino acid sequence
>lcl|BSEQ0013302|Cytochrome P450 3A2
MDLLSALTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYKGLGRF
DMECYKKYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSV
AKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYS
MDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICM
FPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQS
VIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMV
LNETLRLYPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERF
SKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSR
QAILEPEKPIVLKVLPRDAVINGA
Number of residues
504
Molecular Weight
57731.215
Theoretical pI
Not Available
GO Classification
Functions
aromatase activity / demethylase activity / heme binding / iron ion binding / monooxygenase activity / testosterone 6-beta-hydroxylase activity
Processes
drug metabolic process / oxidative demethylation
Components
endoplasmic reticulum membrane
General Function
Testosterone 6-beta-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0013303|Cytochrome P450 3A2 (Cyp3a2)
ATGGACCTGCTTTCAGCTCTCACACTGGAAACCTGGGTCCTCCTGGCAGTCATCCTGGTG
CTTCTCTACCGACTTGGAACCCATAGACATGGAATTTTTAAGAAACAAGGAATTCCTGGG
CCAAAACCTCTGCCCTTTTTAGGCACTGTGCTGAATTACTACAAGGGCTTAGGGAGATTT
GACATGGAGTGCTATAAAAAGTATGGAAAAATATGGGGGTTGTTTGATGGTCAAACGCCT
GTGTTTGCCATCATGGACACAGAGATGATTAAGAATGTACTAGTGAAGGAATGCTTTTCT
GTCTTCACAAACCGGCGGGATTTTGGCCCAGTGGGGATTATGGGGAAAGCTGTCTCTGTA
GCTAAGGATGAGGAGTGGAAGAGATATAGAGCCTTGCTGTCCCCCACGTTCACCAGTGGA
AGACTCAAGGAGATGTTCCCCATCATTGAACAGTATGGAGACATTTTGGTAAAGTACTTG
AAGCAAGAGGCGGAGACAGGCAAGCCTGTCACCATGAAAAAAGTGTTTGGTGCCTACAGC
ATGGATGTGATCACCAGCACATCATTTGGAGTGAACGTCGATTCCCTTAACAACCCAAAG
GATCCTTTTGTGGAGAAAACCAAGAAATTGTTAAGATTTGACTTTTTTGATCCGTTGTTC
TTGTCAGTAGTACTCTTTCCATTCCTCACCCCAATATATGAGATGCTAAATATCTGCATG
TTCCCAAAGGATTCAATAGCATTTTTCCAAAAATTTGTGCACAGAATAAAGGAAACCCGT
CTGGATTCTAAGCATAAGCACCGAGTGGATTTTCTCCAGCTGATGCTGAACGCTCATAAT
AATTCCAAAGACGAAGTGTCTCATAAAGCCCTGTCTGATGTTGAAATCATAGCCCAGTCA
GTTATCTTTATTTTTGCTGGCTATGAAACCACCAGCAGCACACTCTCCTTTGTCTTGTAT
TTCCTGGCCACTCACCCTGATATTCAGAAGAAACTGCAGGAGGAGATCGATGGGGCCCTG
CCGAGTAAGGCACCTCCTACCTACGATATTGTGATGGAAATGGAATACCTGGATATGGTG
TTGAATGAAACTCTCAGATTGTATCCAATTGGTAATAGACTTGAGAGAGTCTGTAAAAAA
GATATAGAACTTGATGGTTTGTTTATACCCAAAGGGTCAGTAGTGACGATTCCAACATAT
GCTCTTCATCATGACCCACAGCACTGGCCAAAGCCTGAGGAATTTCATCCAGAAAGGTTT
AGCAAGGAGAACAAGGGAAGCATTCATCCTTATGTATATCTGCCCTTTGGAAATGGACCC
AGGAACTGCATTGACATGAGGTTTGCTCTCATGAATATGAAACTCGCTCTCACTAAAGTT
CTGCAAAACTTCTCCTTCCAGCCTTGCAAGGAAACACAGATACCTCTGAAATTGAGTAGA
CAAGCAATTCTTGAACCAGAAAAACCCATTGTTCTAAAGGTTCTGCCACGGGATGCAGTC
ATAAATGGAGCCTGA
Chromosome Location
12
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP05183
UniProtKB Entry NameCP3A2_RAT
General References
  1. Gonzalez FJ, Song BJ, Hardwick JP: Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Mol Cell Biol. 1986 Aug;6(8):2969-76. [Article]
  2. Miyata M, Nagata K, Yamazoe Y, Kato R: A gene structure of testosterone 6 beta-hydroxylase (P450IIIA). Biochem Biophys Res Commun. 1991 May 31;177(1):68-73. [Article]
  3. Miyata M, Nagata K, Shimada M, Yamazoe Y, Kato R: Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. Arch Biochem Biophys. 1994 Nov 1;314(2):351-9. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Telhada MB, Pereira TM, Lechner MC: Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. Arch Biochem Biophys. 1992 Nov 1;298(2):715-25. [Article]
  6. Nagata K, Gonzalez FJ, Yamazoe Y, Kato R: Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. J Biochem. 1990 May;107(5):718-25. [Article]
  7. Cooper KO, Reik LM, Jayyosi Z, Bandiera S, Kelley M, Ryan DE, Daniel R, McCluskey SA, Levin W, Thomas PE: Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch Biochem Biophys. 1993 Mar;301(2):345-54. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08834Tauroursodeoxycholic acidapproved, investigationalunknowninducerDetails
DB13975Black cohoshexperimentalnoinhibitorinducerDetails
DB13746Bioallethrinapproved, experimentalnosubstrateDetails
DB01645GenisteininvestigationalunknownsubstrateDetails
DB00869DorzolamideapprovednosubstrateDetails