Tyrosine-protein kinase Fyn
Details
- Name
- Tyrosine-protein kinase Fyn
- Synonyms
- 2.7.10.2
- p59-Fyn
- Proto-oncogene c-Fyn
- Proto-oncogene Syn
- SLK
- Src-like kinase
- Gene Name
- FYN
- UniProtKB Entry
- P06241Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037856|Tyrosine-protein kinase Fyn MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
- Number of residues
- 537
- Molecular Weight
- 60761.49
- Theoretical pI
- 6.65
- GO Classification
- Functionsalpha-tubulin binding / disordered domain specific binding / enzyme binding / identical protein binding / phospholipase activator activity / phospholipase binding / scaffold protein binding / signaling receptor binding / tau protein binding / tau-protein kinase activity / transmembrane transporter binding / type 5 metabotropic glutamate receptor bindingProcessescell surface receptor protein tyrosine kinase signaling pathway / cellular response to amyloid-beta / cellular response to glycine / cellular response to hydrogen peroxide / cellular response to L-glutamate / dendritic spine maintenance / G protein-coupled glutamate receptor signaling pathway / gene expression / heart process / modulation of chemical synaptic transmission / negative regulation of dendritic spine maintenance / negative regulation of hydrogen peroxide biosynthetic process / negative regulation of inflammatory response to antigenic stimulus / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of cysteine-type endopeptidase activity / positive regulation of protein localization to membrane / positive regulation of protein targeting to membrane / positive regulation of tyrosine phosphorylation of STAT protein / protein catabolic process / protein ubiquitination / reelin-mediated signaling pathway / regulation of calcium ion import across plasma membrane / regulation of glutamate receptor signaling pathway / regulation of peptidyl-tyrosine phosphorylation / response to amyloid-beta / response to singlet oxygenComponentscell body / dendrite / glial cell projection / membrane raft / perikaryon / perinuclear endoplasmic reticulum / perinuclear region of cytoplasm / Schaffer collateral - CA1 synapse
- General Function
- Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity)
- Specific Function
- alpha-tubulin binding
- Pfam Domain Function
- SH3_1 (PF00018)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010591|Tyrosine-protein kinase Fyn (FYN) ATGGGCTGTGTGCAATGTAAGGATAAAGAAGCAACAAAACTGACGGAGGAGAGGGACGGC AGCCTGAACCAGAGCTCTGGGTACCGCTATGGCACAGACCCCACCCCTCAGCACTACCCC AGCTTCGGTGTGACCTCCATCCCCAACTACAACAACTTCCACGCAGCCGGGGGCCAAGGA CTCACCGTCTTTGGAGGTGTGAACTCTTCGTCTCATACGGGGACCTTGCGTACGAGAGGA GGAACAGGAGTGACACTCTTTGTGGCCCTTTATGACTATGAAGCACGGACAGAAGATGAC CTGAGTTTTCACAAAGGAGAAAAATTTCAAATATTGAACAGCTCGGAAGGAGATTGGTGG GAAGCCCGCTCCTTGACAACTGGAGAGACAGGTTACATTCCCAGCAATTATGTGGCTCCA GTTGACTCTATCCAGGCAGAAGAGTGGTACTTTGGAAAACTTGGCCGAAAAGATGCTGAG CGACAGCTATTGTCCTTTGGAAACCCAAGAGGTACCTTTCTTATCCGCGAGAGTGAAACC ACCAAAGGTGCCTATTCACTTTCTATCCGTGATTGGGATGATATGAAAGGAGACCATGTC AAACATTATAAAATTCGCAAACTTGACAATGGTGGATACTACATTACCACCCGGGCCCAG TTTGAAACACTTCAGCAGCTTGTACAACATTACTCAGAGAGAGCTGCAGGTCTCTGCTGC CGCCTAGTAGTTCCCTGTCACAAAGGGATGCCAAGGCTTACCGATCTGTCTGTCAAAACC AAAGATGTCTGGGAAATCCCTCGAGAATCCCTGCAGTTGATCAAGAGACTGGGAAATGGG CAGTTTGGGGAAGTATGGATGGGTACCTGGAATGGAAACACAAAAGTAGCCATAAAGACT CTTAAACCAGGCACAATGTCCCCCGAATCATTCCTTGAGGAAGCGCAGATCATGAAGAAG CTGAAGCACGACAAGCTGGTCCAGCTCTATGCAGTGGTGTCTGAGGAGCCCATCTACATC GTCACCGAGTATATGAACAAAGGAAGTTTACTGGATTTCTTAAAAGATGGAGAAGGAAGA GCTCTGAAATTACCAAATCTTGTGGACATGGCAGCACAGGTGGCTGCAGGAATGGCTTAC ATCGAGCGCATGAATTATATCCATAGAGATCTGCGATCAGCAAACATTCTAGTGGGGAAT GGACTCATATGCAAGATTGCTGACTTCGGATTGGCCCGATTGATAGAAGACAATGAGTAC ACAGCAAGACAAGGTGCAAAGTTCCCCATCAAGTGGACGGCCCCCGAGGCAGCCCTGTAC GGGAGGTTCACAATCAAGTCTGACGTGTGGTCTTTTGGAATCTTACTCACAGAGCTGGTC ACCAAAGGAAGAGTGCCATACCCAGGCATGAACAACCGGGAGGTGCTGGAGCAGGTGGAG CGAGGCTACAGGATGCCCTGCCCGCAGGACTGCCCCATCTCTCTGCATGAGCTCATGATC CACTGCTGGAAAAAGGACCCTGAAGAACGCCCCACTTTTGAGTACTTGCAGAGCTTCCTG GAAGACTACTTTACCGCGACAGAGCCCCAGTACCAACCTGGTGAAAACCTGTAA
- Chromosome Location
- 6
- Locus
- 6q21
- External Identifiers
Resource Link UniProtKB ID P06241 UniProtKB Entry Name FYN_HUMAN GenBank Protein ID 338228 GenBank Gene ID M14333 GeneCard ID FYN GenAtlas ID FYN HGNC ID HGNC:4037 PDB ID(s) 1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 2MQI, 2MRJ, 2MRK, 3H0F, 3H0H, 3H0I, 3UA6, 3UA7, 4D8D, 4EIK, 4U17, 4U1P, 4ZNX, 5ZAU, 6EDF, 6IPY, 6IPZ, 7A2J, 7A2K, 7A2L, 7A2M, 7A2N, 7A2O, 7A2P, 7A2Q, 7A2R, 7A2S, 7A2T, 7A2U, 7A2V, 7A2W, 7A2X, 7A2Y, 7A2Z, 7UD6, 8KDX KEGG ID hsa:2534 IUPHAR/Guide To Pharmacology ID 2026 NCBI Gene ID 2534 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Tyrosine-protein kinase Fyn (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dasatinib approved, investigational yes target inhibitormultitarget Details Triglyme experimental yes target inhibitor Details Fostamatinib approved, investigational unknown target inhibitor Details Zotiraciclib investigational unknown target inhibitor Details