Pyruvate decarboxylase

Details

Name
Pyruvate decarboxylase
Synonyms
  • 4.1.1.1
  • PDC
Gene Name
pdc
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Amino acid sequence
>lcl|BSEQ0017043|Pyruvate decarboxylase
MSYTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGY
ARAKGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKTD
YHYQLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMPCAAPGP
ASALFNDEASDEASLNAAVEETLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADALGGAV
ATMAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFNDYSTTGWTDIPD
PKKLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKKTGALDFFKSLNAGELKKAAPAD
PSAPLVNAEIARQVEALLTPNTTVIAETGDSWFNAQRMKLPNGARVEYEMQWGHIGWSVP
AAFGYAVGAPERRNILMVGDGSFQLTAQEVAQMVRLKLPVIIFLINNYGYTIEVMIHDGP
YNNIKNWDYAGLMEVFNGNGGYDSGAGKGLKAKTGGELAEAIKVALANTDGPTLIECFIG
REDCTEELVKWGKRVAAANSRKPVNKLL
Number of residues
568
Molecular Weight
60925.005
Theoretical pI
5.96
GO Classification
Functions
magnesium ion binding / pyruvate decarboxylase activity / thiamine pyrophosphate binding
General Function
Thiamine pyrophosphate binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017044|Pyruvate decarboxylase (pdc)
ATGAGTTATACTGTCGGTACCTATTTAGCGGAGCGGCTTGTCCAGATTGGTCTCAAGCAT
CACTTCGCAGTCGCGGGCGACTACAACCTCGTCCTTCTTGACAACCTGCTTTTGAACAAA
AACATGGAGCAGGTTTATTGCTGTAACGAACTGAACTGCGGTTTCAGTGCAGAAGGTTAT
GCTCGTGCCAAAGGCGCAGCAGCAGCCGTCGTTACCTACAGCGTCGGTGCGCTTTCCGCA
TTTGATGCTATCGGTGGCGCCTATGCAGAAAACCTTCCGGTTATCCTGATCTCCGGTGCT
CCGAACAACAATGATCACGCTGCTGGTCACGTGTTGCATCACGCTCTTGGCAAAACCGAC
TATCACTATCAGTTGGAAATGGCCAAGAACATCACGGCCGCCGCTGAAGCGATTTACACC
CCGGAAGAAGCTCCGGCTAAAATCGATCACGTGATTAAAACTGCTCTTCGTGAGAAGAAG
CCGGTTTATCTCGAAATCGCTTGCAACATTGCTTCCATGCCCTGCGCCGCTCCTGGACCG
GCAAGCGCATTGTTCAATGACGAAGCCAGCGACGAAGCTTCTTTGAATGCAGCGGTTGAA
GAAACCCTGAAATTCATCGCCAACCGCGACAAAGTTGCCGTCCTCGTCGGCAGCAAGCTG
CGCGCAGCTGGTGCTGAAGAAGCTGCTGTCAAATTTGCTGATGCTCTCGGTGGCGCAGTT
GCTACCATGGCTGCTGCAAAAAGCTTCTTCCCAGAAGAAAACCCGCATTACATCGGCACC
TCATGGGGTGAAGTCAGCTATCCGGGCGTTGAAAAGACGATGAAAGAAGCCGATGCGGTT
ATCGCTCTGGCTCCTGTCTTCAACGACTACTCCACCACTGGTTGGACGGATATTCCTGAT
CCTAAGAAACTGGTTCTCGCTGAACCGCGTTCTGTCGTCGTTAACGGCATTCGCTTCCCC
AGCGTCCATCTGAAAGACTATCTGACCCGTTTGGCTCAGAAAGTTTCCAAGAAAACCGGT
GCATTGGACTTCTTCAAATCCCTCAATGCAGGTGAACTGAAGAAAGCCGCTCCGGCTGAT
CCGAGTGCTCCGTTGGTCAACGCAGAAATCGCCCGTCAGGTCGAAGCTCTTCTGACCCCG
AACACGACGGTTATTGCTGAAACCGGTGACTCTTGGTTCAATGCTCAGCGCATGAAGCTC
CCGAACGGTGCTCGCGTTGAATATGAAATGCAGTGGGGTCACATTGGTTGGTCCGTTCCT
GCCGCCTTCGGTTATGCCGTCGGTGCTCCGGAACGTCGCAACATCCTCATGGTTGGTGAT
GGTTCCTTCCAGCTGACGGCTCAGGAAGTCGCTCAGATGGTTCGCCTGAAACTGCCGGTT
ATCATCTTCTTGATCAATAACTATGGTTACACCATCGAAGTTATGATCCATGATGGTCCG
TACAACAACATCAAGAACTGGGATTATGCCGGTCTGATGGAAGTGTTCAACGGTAACGGT
GGTTATGACAGCGGTGCTGGTAAAGGCCTGAAGGCTAAAACCGGTGGCGAACTGGCAGAA
GCTATCAAGGTTGCTCTGGCAAACACCGACGGCCCAACCCTGATCGAATGCTTCATCGGT
CGTGAAGACTGCACTGAAGAATTGGTCAAATGGGGTAAGCGCGTTGCTGCCGCCAACAGC
CGTAAGCCTGTTAACAAGCTCCTCTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP06672
UniProtKB Entry NamePDC_ZYMMO
GenBank Gene IDM15368
General References
  1. Neale AD, Scopes RK, Wettenhall RE, Hoogenraad NJ: Pyruvate decarboxylase of Zymomonas mobilis: isolation, properties, and genetic expression in Escherichia coli. J Bacteriol. 1987 Mar;169(3):1024-8. [Article]
  2. Neale AD, Scopes RK, Wettenhall RE, Hoogenraad NJ: Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis. Nucleic Acids Res. 1987 Feb 25;15(4):1753-61. [Article]
  3. Conway T, Osman YA, Konnan JI, Hoffmann EM, Ingram LO: Promoter and nucleotide sequences of the Zymomonas mobilis pyruvate decarboxylase. J Bacteriol. 1987 Mar;169(3):949-54. [Article]
  4. Reynen M, Sahm H: Comparison of the structural genes for pyruvate decarboxylase in different Zymomonas mobilis strains. J Bacteriol. 1988 Jul;170(7):3310-3. [Article]
  5. Seo JS, Chong H, Park HS, Yoon KO, Jung C, Kim JJ, Hong JH, Kim H, Kim JH, Kil JI, Park CJ, Oh HM, Lee JS, Jin SJ, Um HW, Lee HJ, Oh SJ, Kim JY, Kang HL, Lee SY, Lee KJ, Kang HS: The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4. Nat Biotechnol. 2005 Jan;23(1):63-8. Epub 2004 Dec 12. [Article]
  6. Candy JM, Koga J, Nixon PF, Duggleby RG: The role of residues glutamate-50 and phenylalanine-496 in Zymomonas mobilis pyruvate decarboxylase. Biochem J. 1996 May 1;315 ( Pt 3):745-51. [Article]
  7. Candy JM, Duggleby RG: Structure and properties of pyruvate decarboxylase and site-directed mutagenesis of the Zymomonas mobilis enzyme. Biochim Biophys Acta. 1998 Jun 29;1385(2):323-38. [Article]
  8. Dobritzsch D, Konig S, Schneider G, Lu G: High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis. Implications for substrate activation in pyruvate decarboxylases. J Biol Chem. 1998 Aug 7;273(32):20196-204. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04272Citric acidapproved, nutraceutical, vet_approvedunknownDetails