Glucose-6-phosphate isomerase
Details
- Name
- Glucose-6-phosphate isomerase
- Synonyms
- 5.3.1.9
- AMF
- Autocrine motility factor
- GPI
- Neuroleukin
- NLK
- PGI
- PHI
- Phosphoglucose isomerase
- Phosphohexose isomerase
- SA-36
- Sperm antigen 36
- Gene Name
- GPI
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002385|Glucose-6-phosphate isomerase MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLV TEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMP EVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVA KHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGA HWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGL HHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFT KLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDA STNGLINFIKQQREARVQ
- Number of residues
- 558
- Molecular Weight
- 63146.745
- Theoretical pI
- 8.55
- GO Classification
- Functionsglucose-6-phosphate isomerase activity / intramolecular transferase activity / monosaccharide binding / ubiquitin protein ligase bindingProcessesaldehyde catabolic process / angiogenesis / canonical glycolysis / carbohydrate metabolic process / gene expression / gluconeogenesis / glucose 6-phosphate metabolic process / glucose metabolic process / hemostasis / humoral immune response / learning or memory / methylglyoxal biosynthetic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of neuron apoptotic process / small molecule metabolic process / transcription initiation from RNA polymerase II promoterComponentscytoplasm / cytosol / extracellular exosome / extracellular space / membrane / neuron projection / nucleoplasm / plasma membrane
- General Function
- Ubiquitin protein ligase binding
- Specific Function
- Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
- Pfam Domain Function
- PGI (PF00342)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019079|Glucose-6-phosphate isomerase (GPI) ATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCAC CGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTC AGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTG ACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCC CGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCAC GTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCA GAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGCGGTGAC TGGAAGGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGGCGGCTCC GACCTGGGACCCCTCATGGTGACTGAAGCCCTTAAGCCATACTCTTCAGGAGGTCCCCGC GTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAAC CCCGAGTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACG AATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGGCCAAGGATCCTTCTGCAGTGGCG AAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCT CAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATC GGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCT CACTGGATGGACCAGCACTTCCGCACGACGCCCCTGGAGAAGAACGCCCCCGTCTTGCTG GCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCC TATGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAAT GGGAAATACATCACCAAATCTGGAACCCGTGTGGACCACCAGACAGGCCCCATTGTGTGG GGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAG ATGATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTG CATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACAGAGGCCCTGATGAGGGGAAAA TCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAG AGGCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACC AAGCTCACACCATTCATGCTTGGAGCCTTGGTCGCCATGTATGAGCACAAGATCTTCGTT CAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAG CTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCT TCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAA
- Chromosome Location
- 19
- Locus
- 19q13.1
- External Identifiers
Resource Link UniProtKB ID P06744 UniProtKB Entry Name G6PI_HUMAN GenBank Protein ID 189238 GenBank Gene ID K03515 GenAtlas ID GPI HGNC ID HGNC:4458 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02007 alpha-D-glucose 6-phosphate experimental unknown Details DB02076 6-phospho-D-gluconic acid experimental unknown Details DB02093 5-phospho-D-arabinohydroxamic acid experimental unknown Details DB02548 D-glucitol 6-phosphate experimental unknown Details DB03042 5-Phosphoarabinonic Acid experimental unknown Details DB03581 Glucose-6-Phosphate experimental unknown Details DB03937 D-erythrose 4-phosphate experimental unknown Details DB04493 Fructose-6-phosphate experimental unknown Details DB09130 Copper approved, investigational unknown Details DB11638 Artenimol approved, experimental, investigational unknown ligand Details