Phosphoprotein
Details
- Name
- Phosphoprotein
- Synonyms
- Protein M1
- Protein P
- Gene Name
- P
- Organism
- Rabies virus (strain Pasteur vaccins / PV)
- Amino acid sequence
>lcl|BSEQ0052117|Phosphoprotein MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDNLPEDMGRLHLDD GKSPNPGEMAKVGEGKYREDFQMDEGEDPSLLFQSYLDNVGVQIVRQIRSGERFLKIWSQ TVEEIISYVAVNFPNPPGKSSEDKSTQTTGRELKKETTPTPSQRESQSSKARMAAQTASG PPALEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGILLYNFEQLKMNLDDIVKE AKNVPGVTRLARDGSKLPLRCVLGWVALANSKKFQLLVESNKLSKIMQDDLNRYTSC
- Number of residues
- 297
- Molecular Weight
- 33165.98
- Theoretical pI
- Not Available
- GO Classification
- FunctionsRNA-directed 5'-3' RNA polymerase activityProcessesmicrotubule-dependent intracellular transport of viral material towards nucleus / suppression by virus of host STAT1 activity / suppression by virus of host STAT2 activity / suppression by virus of host type I interferon-mediated signaling pathway / viral entry into host cell / viral transcriptionComponentshost cell cytoplasm / host cell nucleus / virion
- General Function
- Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).
- Specific Function
- Rna-directed 5'-3' rna polymerase activity
- Pfam Domain Function
- PP_M1 (PF03012)
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0052118|Phosphoprotein (P) ATGAGCAAGATCTTTGTCAATCCTAGTGCTATTAGAGCCGGTCTGGCCGATCTTGAGATG GCTGAAGAAACTGTTGATCTGATCAATAGAAATATCGAAGACAATCAGGCTCATCTCCAA GGGGAACCCATAGAAGTGGACAATCTCCCTGAGGATATGGGGCGACTTCACCTGGATGAT GGAAAATCGCCCAACCCTGGTGAGATGGCCAAGGTGGGAGAAGGCAAGTATCGAGAGGAC TTTCAGATGGATGAAGGAGAGGATCCTAGCCTCCTGTTCCAGTCATACCTGGACAATGTT GGAGTCCAAATAGTCAGACAAATAAGGTCAGGAGAGAGATTTCTCAAGATATGGTCACAG ACCGTAGAAGAGATTATATCCTATGTCGCGGTCAACTTTCCCAACCCTCCAGGAAAGTCT TCAGAGGATAAATCAACCCAGACTACCGGCCGAGAGCTCAAGAAGGAGACAACACCCACT CCTTCTCAGAGAGAAAGCCAATCCTCGAAAGCCAGGATGGCGGCTCAAACTGCTTCTGGC CCTCCAGCCCTTGAATGGTCGGCCACCAATGAAGAGGATGATCTATCAGTGGAGGCTGAG ATCGCTCACCAGATTGCAGAAAGTTTCTCCAAAAAATATAAGTTTCCCTCTCGATCCTCA GGGATACTCTTGTATAATTTTGAGCAATTGAAAATGAACCTTGATGATATAGTTAAAGAG GCAAAAAATGTACCAGGTGTGACCCGTTTAGCCCGTGACGGGTCCAAACTCCCCCTAAGA TGTGTACTGGGATGGGTCGCCTTGGCCAACTCTAAGAAATTCCAGTTGTTAGTCGAATCC AACAAGCTGAGTAAAATCATGCAAGATGACTTGAATCGCTATACATCTTGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06747 UniProtKB Entry Name PHOSP_RABVP - General References
- Tordo N, Poch O, Ermine A, Keith G, Rougeon F: Walking along the rabies genome: is the large G-L intergenic region a remnant gene? Proc Natl Acad Sci U S A. 1986 Jun;83(11):3914-8. doi: 10.1073/pnas.83.11.3914. [Article]