Acetyl-CoA acetyltransferase

Details

Name
Acetyl-CoA acetyltransferase
Synonyms
  • 2.3.1.9
  • Acetoacetyl-CoA thiolase
Gene Name
phbA
Organism
Zoogloea ramigera
Amino acid sequence
>lcl|BSEQ0010998|Acetyl-CoA acetyltransferase
MSTPSIVIASARTAVGSFNGAFANTPAHELGATVISAVLERAGVAAGEVNEVILGQVLPA
GEGQNPARQAAMKAGVPQEATAWGMNQLCGSGLRAVALGMQQIATGDASIIVAGGMESMS
MAPHCAHLAGGVKMGDFKMIDTMIKDGLTDAFYGYHMGTTAENVAKQWQLSRDEQDAFAV
ASQNKAEAAQKDGRFKDEIVPFIVKGRKGDITVDADEYIRHGATLDSMAKLRPAFDKEGT
VTAGNASGLNDGAAAALLMSEAEASRRGIQPLGRIVSWATVGVDPKVMGTGPIPASRKAL
ERAGWKIGDLDLVEANEAFAAQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGARILNT
LLFEMKRRGARKGLATLCIGGGMGVAMCIESL
Number of residues
392
Molecular Weight
40472.955
Theoretical pI
6.26
GO Classification
Functions
acetyl-CoA C-acetyltransferase activity
Processes
poly-hydroxybutyrate biosynthetic process
Components
cytoplasm
General Function
Acetyl-coa c-acetyltransferase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0002822|1176 bp
ATGAGCACCCCGTCCATCGTCATCGCCAGCGCCCGCACCGCGGTCGGTTCCTTCAACGGC
GCTTTCGCCAACACGCCCGCCCATGAACTCGGGGCGACCGTGATTTCGGCGGTTCTCGAG
CGCGCGGGCGTTGCGGCGGGCGAGGTGAACGAGGTGATTCTCGGCCAGGTGCTGCCGGCC
GGCGAAGGCCAGAACCCGGCCCGCCAGGCCGCCATGAAGGCCGGCGTGCCGCAGGAGGCG
ACCGCCTGGGGCATGAACCAGCTTTGCGGCTCGGGCCTGCGCGCCGTCGCGCTCGGCATG
CAGCAGATCGCCACGGGCGATGCGAGCATCATCGTCGCCGGCGGCATGGAATCCATGTCC
ATGGCCCCGCATTGCGCGCATCTGGCCGGCGTGAAGATGGGCGATTTCAAGATGATCGAC
ACGATGATCAAGGACGGCCTGACCGACGCCTTCTACGGCTACCACATGGGCACGACCGCC
GAGAATGTCGCCAAGCAGTGGCAGCTTTCCCGCGACGAGCAGGACGCCTTCGCCGTCGCC
TCGCAGAACAAGGCCGAGGCCGCCCAGAAGGACGGCCGCTTCAAGGACGAGATCGTTCCC
TTCATCGTCAAGGGCCGCAAGGGCGACATCACGGTCGATGCCGACGAATATATCCGCCAC
GGCGCGACGCTCGATTCCATGGCGAAGCTCCGCCCGGCCTTCGACAAGGAAGGCACGGTG
ACGGCCGGCAACGCCTCCGGCCTCAATGACGGCGCGGCCGCGGCCCTCCTGATGAGCGAA
GCGGAAGCCTCGCGCCGCGGCATCCAGCCGCTCGGCCGCATCGTTTCCTGGGCGACGGTC
GGCGTCGATCCCAAGGTCATGGGCACCGGCCCGATCCCGGCCTCCCGCAAGGCGCTCGAG
CGCGCCGGCTGGAAGATCGGCGATCTCGACCTCGTGGAAGCCAACGAAGCCTTCGCGGCG
CAGGCCTGCGCGGTCAACAAGGACCTCGGCTGGGATCCGTCCATCGTCAACGTCAACGGC
GGTGCCATCGCCATCGGCCACCCGATCGGCGCGTCCGGCGCCCGCATCCTCAACACGCTC
CTCTTCGAGATGAAGCGTCGCGGCGCCCGCAAGGGTCTCGCCACGCTCTGCATCGGCGGC
GGCATGGGCGTGGCGATGTGCATCGAGAGCCTTTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP07097
UniProtKB Entry NameTHIL_ZOORA
GenBank Protein ID155618
GenBank Gene IDJ02631
General References
  1. Peoples OP, Masamune S, Walsh CT, Sinskey AJ: Biosynthetic thiolase from Zoogloea ramigera. III. Isolation and characterization of the structural gene. J Biol Chem. 1987 Jan 5;262(1):97-102. [Article]
  2. Peoples OP, Sinskey AJ: Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16. Characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase. J Biol Chem. 1989 Sep 15;264(26):15293-7. [Article]
  3. Palmer MA, Differding E, Gamboni R, Williams SF, Peoples OP, Walsh CT, Sinskey AJ, Masamune S: Biosynthetic thiolase from Zoogloea ramigera. Evidence for a mechanism involving Cys-378 as the active site base. J Biol Chem. 1991 May 5;266(13):8369-75. [Article]
  4. Modis Y, Wierenga RK: Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase. J Mol Biol. 2000 Apr 14;297(5):1171-82. [Article]
  5. Modis Y, Wierenga RK: A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism. Structure. 1999 Oct 15;7(10):1279-90. [Article]
  6. Kursula P, Ojala J, Lambeir AM, Wierenga RK: The catalytic cycle of biosynthetic thiolase: a conformational journey of an acetyl group through four binding modes and two oxyanion holes. Biochemistry. 2002 Dec 31;41(52):15543-56. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01915S-HydroxycysteineexperimentalunknownDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails
DB02039S-Acetyl-CysteineexperimentalunknownDetails
DB02160S-Butyryl-CysteinexperimentalunknownDetails
DB03045Pantothenyl-Aminoethanol-Acetate Pivalic AcidexperimentalunknownDetails
DB03059Acetoacetyl-CoAexperimentalunknownDetails
DB08328PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACIDexperimentalunknownDetails
DB08408(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoateexperimentalunknownDetails