Asialoglycoprotein receptor 2
Details
- Name
- Asialoglycoprotein receptor 2
- Synonyms
- ASGP-R 2
- ASGPR 2
- C-type lectin domain family 4 member H2
- CLEC4H2
- Hepatic lectin H2
- HL-2
- Gene Name
- ASGR2
- UniProtKB Entry
- P07307Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037163|Asialoglycoprotein receptor 2 MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFS LLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGS VGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVN WVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDS DGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVC EKRRNATGEVA
- Number of residues
- 311
- Molecular Weight
- 35092.04
- Theoretical pI
- 6.34
- GO Classification
- FunctionsD-mannose binding / fucose bindingProcessesendocytosisComponentsendoplasmic reticulum quality control compartment / external side of plasma membrane / perinuclear region of cytoplasm / plasma membrane
- General Function
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface
- Specific Function
- asialoglycoprotein receptor activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 59-79
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0011535|Asialoglycoprotein receptor 2 (ASGR2) ATGGCCAAGGACTTTCAAGATATCCAGCAGCTGAGCTCGGAGGAAAATGACCATCCTTTC CATCAAGGTGAGGGGCCAGGCACTCGCAGGCTGAATCCCAGGAGAGGAAATCCATTTTTG AAAGGGCCACCTCCTGCCCAGCCCCTGGCACAGCGTCTCTGCTCCATGGTCTGCTTCAGT CTGCTTGCCCTGAGCTTCAACATCCTGCTGCTGGTGGTCATCTGTGTGACTGGGTCCCAA AGTGAGGGTCACAGGGGTGCACAGCTGCAAGCCGAGCTGCGGAGCCTGAAGGAAGCTTTC AGCAACTTCTCCTCGAGCACCCTGACGGAGGTCCAGGCAATCAGCACCCACGGAGGCAGC GTGGGTGACAAGATCACATCCCTAGGAGCCAAGCTGGAGAAACAGCAGCAGGACCTGAAA GCAGATCACGATGCCCTGCTCTTCCATCTGAAGCACTTCCCCGTGGACCTGCGCTTCGTG GCCTGCCAGATGGAGCTCCTCCACAGCAACGGCTCCCAAAGGACCTGCTGCCCCGTCAAC TGGGTGGAGCACCAAGGCAGCTGCTACTGGTTCTCTCACTCCGGGAAGGCCTGGGCTGAG GCGGAGAAGTACTGCCAGCTGGAGAACGCACACCTGGTGGTCATCAACTCCTGGGAGGAG CAGAAATTCATTGTACAACACACGAACCCCTTCAATACCTGGATAGGTCTCACGGACAGT GATGGCTCTTGGAAATGGGTGGATGGCACAGACTATAGGCACAACTACAAGAACTGGGCT GTCACTCAGCCAGATAATTGGCACGGGCACGAGCTGGGTGGAAGTGAAGACTGTGTTGAA GTCCAGCCGGATGGCCGCTGGAACGATGACTTCTGCCTGCAGGTGTACCGCTGGGTGTGT GAGAAAAGGCGGAATGCCACCGGCGAGGTGGCCTGA
- Chromosome Location
- 17
- Locus
- 17p13.1
- External Identifiers
Resource Link UniProtKB ID P07307 UniProtKB Entry Name ASGR2_HUMAN GenBank Protein ID 179081 GenBank Gene ID M11025 GeneCard ID ASGR2 GenAtlas ID ASGR2 HGNC ID HGNC:743 PDB ID(s) 8URF KEGG ID hsa:433 NCBI Gene ID 433 - General References
- Spiess M, Lodish HF: Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. Proc Natl Acad Sci U S A. 1985 Oct;82(19):6465-9. [Article]
- Paietta E, Stockert RJ, Racevskis J: Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. Hepatology. 1992 Mar;15(3):395-402. [Article]
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- Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. Genomics. 2001 Sep;77(1-2):58-64. [Article]
- Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [Article]
- Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Asialoglycoprotein receptor 2 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Antihemophilic factor, human recombinant approved, investigational unknown target binder Details Lonoctocog alfa approved, investigational unknown target binder Details Moroctocog alfa approved unknown target binder Details