Trypsin-2

Details

Name
Trypsin-2
Synonyms
  • 3.4.21.4
  • Anionic trypsinogen
  • Serine protease 2
  • TRY2
  • TRYP2
  • Trypsin II
Gene Name
PRSS2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0017464|Trypsin-2
MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVIN
SRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT
NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK
DTIAANS
Number of residues
247
Molecular Weight
26487.55
Theoretical pI
Not Available
GO Classification
Functions
calcium ion binding / serine-type endopeptidase activity
Processes
collagen catabolic process / digestion / extracellular matrix disassembly / extracellular matrix organization / innate immune response / positive regulation of cell adhesion / positive regulation of cell growth / proteolysis
Components
extracellular matrix / extracellular region / extracellular space
General Function
Serine-type endopeptidase activity
Specific Function
In the ileum, may be involved in defensin processing, including DEFA5.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP07478
UniProtKB Entry NameTRY2_HUMAN
HGNC IDHGNC:9483
General References
  1. Emi M, Nakamura Y, Ogawa M, Yamamoto T, Nishide T, Mori T, Matsubara K: Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene. 1986;41(2-3):305-10. [Article]
  2. Kimland M, Russick C, Marks WH, Borgstrom A: Immunoreactive anionic and cationic trypsin in human serum. Clin Chim Acta. 1989 Sep 15;184(1):31-46. [Article]
  3. Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL: Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun;3(6):583-90. Epub 2002 May 20. [Article]
  4. Sahin-Toth M, Kukor Z, Nemoda Z: Human cationic trypsinogen is sulfated on Tyr154. FEBS J. 2006 Nov;273(22):5044-50. [Article]
  5. Szabo A, Salameh MA, Ludwig M, Radisky ES, Sahin-Toth M: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids. PLoS One. 2014 Jul 10;9(7):e102063. doi: 10.1371/journal.pone.0102063. eCollection 2014. [Article]
  6. Ronai Z, Witt H, Rickards O, Destro-Bisol G, Bradbury AR, Sahin-Toth M: A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). Biochem J. 2009 Feb 15;418(1):155-61. doi: 10.1042/BJ20081848. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01805MonoisopropylphosphorylserineexperimentalunknownDetails
DB01973O-Benzylsulfonyl-SerineexperimentalunknownDetails
DB03976PhosphorylisopropaneexperimentalunknownDetails
DB02464BenzylamineexperimentalunknownDetails
DB03127BenzamidineexperimentalunknownDetails
DB04325PhenethylamineexperimentalunknownDetails
DB044103-PhenylpropylamineexperimentalunknownDetails