Matrix protein

Details

Name

Matrix protein

Synonyms

• Phosphoprotein M2

Gene Name

M

Organism

Rabies virus (strain Pasteur vaccins / PV)

Amino acid sequence

>lcl|BSEQ0052125|Matrix protein
MNFLRKIVKNCRDEDTQKPSPVSAPLDDDDLWLPPPEYVPLKELTSKKNRRNFCINGGVK
VCSPNGYSFGILRHILRSFDEIYSGNHRMVGLVKVVIGLALSGAPVPEGMNWVYKLRRTL
IFQWADSRGPLEGEELEYSQEITWDDNTEFVGLQIRVSAKQCHIRGRIWCINMNSRAGQL
WSDMSLQTQRSEEDKDSSLLLE

Number of residues

202

Molecular Weight

23157.225

Theoretical pI

Not Available

GO Classification

Functions

structural constituent of virion

Processes

viral budding via host ESCRT complex

Components

host cell endomembrane system / viral envelope / virion membrane

General Function

Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).

Specific Function

Structural constituent of virion

Pfam Domain Function

• Rhabdo_M2 (PF04785)

Transmembrane Regions

Not Available

Cellular Location

Virion membrane

Gene sequence

>lcl|BSEQ0052126|Matrix protein (M)
ATGAACTTTCTACGTAAGATAGTGAAAAATTGCAGGGACGAGGACACTCAAAAACCCTCT
CCCGTGTCAGCCCCTCTGGATGACGATGACTTGTGGCTTCCACCCCCTGAATACGTCCCG
CTAAAAGAACTTACAAGCAAGAAGAACAGGAGGAACTTTTGTATCAACGGAGGGGTTAAA
GTGTGTAGCCCGAATGGTTACTCGTTCGGGATCCTGCGGCACATTCTGAGATCATTCGAC
GAGATATATTCTGGGAATCATAGGATGGTCGGGTTAGTCAAAGTAGTTATTGGACTGGCT
TTGTCAGGAGCTCCAGTCCCTGAGGGCATGAACTGGGTATACAAGTTGAGGAGAACCCTT
ATCTTCCAGTGGGCTGATTCCAGGGGCCCTCTTGAAGGGGAGGAGTTGGAATACTCTCAG
GAGATCACTTGGGATGATAATACTGAGTTCGTCGGATTGCAAATAAGAGTGAGTGCAAAA
CAGTGTCATATCCGGGGCAGAATCTGGTGTATCAACATGAACTCGAGAGCAGGTCAACTA
TGGTCTGACATGTCTCTTCAGACACAAAGGTCCGAAGAGGACAAAGATTCCTCTCTGCTT
CTAGAATAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P08671
UniProtKB Entry Name	MATRX_RABVP

General References

1. Tordo N, Poch O, Ermine A, Keith G, Rougeon F: Walking along the rabies genome: is the large G-L intergenic region a remnant gene? Proc Natl Acad Sci U S A. 1986 Jun;83(11):3914-8. doi: 10.1073/pnas.83.11.3914. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB11603	Rabies immune globulin, human	approved	yes	antibody	Details