Cytochrome P450 2C11
Details
- Name
- Cytochrome P450 2C11
- Synonyms
- 1.14.14.1
- Cyp2c
- Cyp2c-11
- CYPIIC11
- Cytochrome P-450(M-1)
- Cytochrome P450-UT-2
- Cytochrome P450-UT-A
- Cytochrome P450H
- Gene Name
- Cyp2c11
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0051630|Cytochrome P450 2C11 MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKV YGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQW KEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICS IIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYI KNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTE TTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYID LVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFK KSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLP PFYEACFIPVQRADSLSSHL
- Number of residues
- 500
- Molecular Weight
- 57180.595
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / caffeine oxidase activity / drug binding / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / steroid hydroxylase activity / testosterone 16-alpha-hydroxylase activityProcessescellular amide metabolic process / drug catabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / hematopoietic progenitor cell differentiation / monocarboxylic acid metabolic process / monoterpenoid metabolic process / oxidation-reduction process / oxidative demethylation / steroid metabolic process / urea metabolic process / xenobiotic metabolic processComponentsendoplasmic reticulum membrane / intracellular membrane-bounded organelle / organelle membrane
- General Function
- Metabolizes testosterone mainly in positions 2 alpha and 16 alpha.
- Specific Function
- Arachidonic acid epoxygenase activity
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0051631|Cytochrome P450 2C11 (Cyp2c11) ATGGATCCAGTCCTAGTCCTGGTGCTCACTCTCTCCTCTCTGCTTCTCCTCTCACTCTGG AGACAGAGCTTTGGGAGAGGGAAGCTCCCTCCTGGTCCAACACCTCTCCCAATCATTGGA AACACCCTTCAGATATATATGAAGGACATCGGCCAATCAATAAAAAAGTTTTCAAAAGTC TACGGCCCTATATTTACTCTGTATTTGGGCATGAAGCCCTTTGTGGTGTTGCATGGGTAT GAAGCTGTGAAGGAAGCTCTTGTTGATCTAGGAGAGGAATTTTCTGGAAGAGGCAGTTTT CCAGTATCTGAAAGAGTTAACAAGGGCCTTGGAGTCATTTTTAGCAATGGGATGCAATGG AAGGAGATCCGGCGTTTCTCCATCATGACCCTGAGGACTTTTGGGATGGGCAAGAGGACC ATTGAGGACCGTATTCAAGAGGAGGCTCAGTGCCTTGTGGAGGAACTGAGGAAGAGCAAA GGTGCCCCTTTTGATCCCACCTTTATCCTGGGCTGTGCTCCCTGCAATGTGATATGCTCC ATTATTTTCCAGAATCGCTTTGATTATAAAGATCCGACTTTTCTTAACTTGATGCACAGA TTTAATGAAAACTTCAGGCTTTTCAGCTCCCCATGGCTACAGGTCTGCAATACTTTCCCT GCCATTATTGATTACTTCCCTGGAAGTCATAACCAAGTACTTAAGAATTTCTTCTATATA AAAAACTATGTTTTGGAGAAAGTAAAAGAACACCAAGAGTCCTTGGACAAGGACAATCCT CGGGACTTCATTGATTGTTTCTTGAACAAAATGGAACAGGAAAAGCACAATCCGCAGTCT GAGTTTACCCTTGAAAGCTTGGTGGCTACTGTAACTGACATGTTTGGAGCTGGCACAGAA ACAACAAGTACCACTCTGAGGTATGGACTCCTGCTGCTGCTGAAACACGTGGATGTCACA GCTAAAGTCCAGGAAGAGATAGAACGTGTAATTGGCAGAAACCGGAGCCCCTGCATGAAA GACAGGAGCCAGATGCCCTACACGGATGCTGTAGTGCATGAGATCCAGAGATATATTGAC CTTGTCCCCACAAACCTGCCTCATTTAGTGACACGTGATATAAAATTCAGAAACTACTTC ATTCCCAAGGGTACCAATGTGATAGTATCGCTGTCATCCATACTGCATGATGACAAAGAA TTTCCTAATCCAGAGAAGTTTGACCCTGGTCACTTTCTAGATGAGAGAGGTAACTTTAAG AAGAGTGACTACTTTATGCCATTCTCAGCAGGAAAGAGGATATGTGCAGGAGAAGCCCTG GCTCGCACGGAGCTGTTTTTGTTCTTCACCACCATTTTACAGAATTTTAACCTGAAGTCT CTGGTTGATGTAAAAGACATTGACACAACACCAGCTATCAGTGGATTTGGCCATTTGCCC CCTTTTTACGAGGCTTGTTTTATTCCTGTGCAAAGGGCAGACTCTCTAAGCTCTCATCTG TAA
- Chromosome Location
- 1
- Locus
- 1q53
- External Identifiers
Resource Link UniProtKB ID P08683 UniProtKB Entry Name CP2CB_RAT - General References
- Yoshioka H, Morohashi K, Sogawa K, Miyata T, Kawajiri K, Hirose T, Inayama S, Fujii-Kuriyama Y, Omura T: Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers. J Biol Chem. 1987 Feb 5;262(4):1706-11. [Article]
- Morishima N, Yoshioka H, Higashi Y, Sogawa K, Fujii-Kuriyama Y: Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver. Biochemistry. 1987 Dec 15;26(25):8279-85. [Article]
- Strom A, Mode A, Zaphiropoulos P, Nilsson AG, Morgan E, Gustafsson JA: Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver. Acta Endocrinol (Copenh). 1988 Jun;118(2):314-20. [Article]
- Biagini C, Celier C: cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells. Arch Biochem Biophys. 1996 Feb 15;326(2):298-305. doi: 10.1006/abbi.1996.0079. [Article]
- Zaphiropoulos PG, Mode A, Strom A, Husman B, Andersson G, Gustafsson JA: Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha. Acta Med Scand Suppl. 1988;723:161-7. [Article]
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- Strom A, Eguchi H, Mode A, Legraverend C, Tollet P, Stromstedt PE, Gustafsson JA: Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver. DNA Cell Biol. 1994 Aug;13(8):805-19. [Article]
- Matsumoto T, Emi Y, Kawabata S, Omura T: Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. J Biochem. 1986 Nov;100(5):1359-71. [Article]