Tropomyosin alpha-1 chain

Details

Name
Tropomyosin alpha-1 chain
Synonyms
  • Alpha-tropomyosin
  • C15orf13
  • TMSA
  • Tropomyosin-1
Gene Name
TPM1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049787|Tropomyosin alpha-1 chain
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY
SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE
ERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAE
FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Number of residues
284
Molecular Weight
32708.175
Theoretical pI
Not Available
GO Classification
Functions
actin binding / actin filament binding / cytoskeletal protein binding / structural constituent of cytoskeleton / structural constituent of muscle
Processes
actin filament organization / cardiac muscle contraction / cellular response to reactive oxygen species / cytoskeleton organization / in utero embryonic development / movement of cell or subcellular component / muscle contraction / muscle filament sliding / negative regulation of cell migration / negative regulation of vascular associated smooth muscle cell migration / negative regulation of vascular smooth muscle cell proliferation / positive regulation of ATPase activity / positive regulation of cell adhesion / positive regulation of heart rate by epinephrine / positive regulation of stress fiber assembly / regulation of cell shape / regulation of heart contraction / regulation of muscle contraction / ruffle organization / sarcomere organization / ventricular cardiac muscle tissue morphogenesis / wound healing
Components
actin cytoskeleton / actin filament / bleb / cytoskeleton / cytosol / filamentous actin / muscle thin filament tropomyosin / ruffle membrane / sarcomere / stress fiber
General Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Specific Function
Actin binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0049788|Tropomyosin alpha-1 chain (TPM1)
ATGGACGCCATCAAGAAGAAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGAT
CGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGCAAGCAGCTGGAA
GATGAGCTGGTGTCACTGCAAAAGAAACTCAAGGGCACCGAAGATGAACTGGACAAATAC
TCTGAGGCTCTCAAAGATGCCCAGGAGAAGCTGGAGCTGGCAGAGAAAAAGGCCACCGAT
GCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGAT
CGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCA
GATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAA
ATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGC
AAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAG
GAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATG
GATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGA
TATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAG
TTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTG
TACGCTCAGAAACTGAAGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAACGAT
ATGACTTCCATGTAA
Chromosome Location
15
Locus
15q22.2
External Identifiers
ResourceLink
UniProtKB IDP09493
UniProtKB Entry NameTPM1_HUMAN
HGNC IDHGNC:12010
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails