Phospholipase C

Details

Name
Phospholipase C
Synonyms
  • 3.1.4.3
  • Cereolysin A
  • Phosphatidylcholine cholinephosphohydrolase
  • PLC
Gene Name
plc
Organism
Bacillus cereus
Amino acid sequence
>lcl|BSEQ0011104|Phospholipase C
MKKKVLALAAAITVVAPLQSVAFAHENDGGSKIKIVHRWSAEDKHKEGVNSHLWIVNRAI
DIMSRNTTLVKQDRVAQLNEWRTELENGIYAADYENPYYDNSTFASHFYDPDNGKTYIPF
AKQAKETGAKYFKLAGESYKNKDMKQAFFYLGLSLHYLGDVNQPMHAANFTNLSYPQGFH
SKYENFVDTIKDNYKVTDGNGYWNWKGTNPEEWIHGAAVVAKQDYSGIVNDNTKDWFVKA
AVSQEYADKWRAEVTPMTGKRLMDAQRVTAGYIQLWFDTYGDR
Number of residues
283
Molecular Weight
32383.1
Theoretical pI
7.93
GO Classification
Functions
phosphatidylcholine phospholipase C activity / zinc ion binding
Processes
hemolysis in other organism
General Function
Zinc ion binding
Specific Function
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0003096|852 bp
ATGAAAAAGAAAGTACTTGCTTTAGCAGCAGCTATTACAGTAGTAGCTCCTTTACAAAGC
GTTGCATTTGCTCATGAAAATGATGGGGGAAGTAAAATAAAAATAGTTCACCGCTGGTCT
GCTGAAGATAAACATAAAGAAGGTGTAAATTCTCATTTATGGATTGTAAACCGTGCGATT
GATATTATGTCTCGCAATACAACACTTGTAAAACAAGATCGAGTTGCACAATTAAATGAA
TGGCGTACGGAGTTAGAGAACGGTATTTATGCTGCTGACTATGAAAATCCTTATTATGAT
AATAGCACATTTGCTTCACATTTCTATGATCCAGACAATGGAAAAACATATATTCCATTT
GCAAAGCAGGCAAAAGAAACTGGCGCTAAATATTTTAAATTAGCTGGTGAATCATACAAA
AATAAAGATATGAAACAAGCATTCTTCTATTTAGGATTATCTCTTCATTATTTAGGAGAT
GTAAACCAACCGATGCATGCGGCAAACTTTACAAATCTTTCATATCCACAAGGATTCCAT
TCTAAATATGAAAACTTTGTAGATACGATAAAAGATAATTATAAAGTAACGGATGGAAAT
GGATATTGGAACTGGAAAGGTACAAATCCAGAAGAGTGGATTCATGGAGCGGCAGTAGTA
GCGAAACAAGATTACTCTGGAATTGTAAATGATAATACGAAAGATTGGTTCGTAAAAGCA
GCTGTGTCACAAGAATATGCAGATAAATGGCGCGCTGAAGTTACACCAATGACAGGTAAG
CGATTAATGGATGCACAACGTGTTACTGCTGGATACATTCAGCTTTGGTTTGATACGTAC
GGAGATCGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP09598
UniProtKB Entry NamePHLC_BACCE
GenBank Protein ID312906
GenBank Gene IDX64141
General References
  1. Johansen T, Holm T, Guddal PH, Sletten K, Haugli FB, Little C: Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase C of Bacillus cereus. Gene. 1988 May 30;65(2):293-304. [Article]
  2. Gavrilenko IV, Baida GE, Karpov AV, Kuz'min NP: [Nucleotide sequence of phospholipase C and sphingomyelinase genes from Bacillus cereus BKM-B164]. Bioorg Khim. 1993 Jan;19(1):133-8. [Article]
  3. Yamada A, Tsukagoshi N, Udaka S, Sasaki T, Makino S, Nakamura S, Little C, Tomita M, Ikezawa H: Nucleotide sequence and expression in Escherichia coli of the gene coding for sphingomyelinase of Bacillus cereus. Eur J Biochem. 1988 Aug 1;175(2):213-20. [Article]
  4. Otnaess AB, Little C, Sletten K, Wallin R, Johnsen S, Flengsrud R, Prydz H: Some characteristics of phospholipase C from Bacillus cereus. Eur J Biochem. 1977 Oct 3;79(2):459-68. [Article]
  5. Ikeda K, Inoue S, Amasaki C, Teshima K, Ikezawa H: Kinetics of the hydrolysis of monodispersed and micellar phosphatidylcholines catalyzed by a phospholipase C from Bacillus cereus. J Biochem. 1991 Jul;110(1):88-95. [Article]
  6. Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z: High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature. 1989 Mar 23;338(6213):357-60. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB022251,2-Di-N-Pentanoyl-Sn-Glycero-3-DithiophosphocholineexperimentalunknownDetails
DB03827(3s)-3,4-Di-N-Hexanoyloxybutyl-1-PhosphocholineexperimentalunknownDetails