Pro-cathepsin H

Details

Name
Pro-cathepsin H
Synonyms
  • CPSB
Gene Name
CTSH
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012762|Pro-cathepsin H
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
Number of residues
335
Molecular Weight
37393.43
Theoretical pI
8.19
GO Classification
Functions
aminopeptidase activity / cysteine-type endopeptidase activator activity involved in apoptotic process / cysteine-type endopeptidase activity / cysteine-type peptidase activity / endopeptidase activity / HLA-A specific activating MHC class I receptor activity / peptidase activity / serine-type endopeptidase activity / thyroid hormone binding
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process / adaptive immune response / antigen processing and presentation / bradykinin catabolic process / cellular protein metabolic process / cellular response to thyroid hormone stimulus / dichotomous subdivision of terminal units involved in lung branching / ERK1 and ERK2 cascade / immune response-regulating signaling pathway / membrane protein proteolysis / metanephros development / negative regulation of apoptotic process / neuropeptide catabolic process / positive regulation of angiogenesis / positive regulation of apoptotic signaling pathway / positive regulation of cell migration / positive regulation of cell proliferation / positive regulation of epithelial cell migration / positive regulation of gene expression / positive regulation of peptidase activity / protein destabilization / proteolysis / proteolysis involved in cellular protein catabolic process / response to retinoic acid / surfactant homeostasis / T cell mediated cytotoxicity / zymogen activation
Components
alveolar lamellar body / cytosol / extracellular exosome / extracellular space / lysosome / multivesicular body lumen
General Function
Thyroid hormone binding
Specific Function
Important for the overall degradation of proteins in lysosomes.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Lysosome
Gene sequence
>lcl|BSEQ0012763|Pro-cathepsin H (CTSH)
ATGTGGGCCACGCTGCCGCTGCTCTGCGCCGGGGCCTGGCTCCTGGGAGTCCCCGTCTGC
GGTGCCGCCGAACTGTGCGTGAACTCCTTAGAGAAGTTTCACTTCAAGTCATGGATGTCT
AAGCACCGTAAGACCTACAGTACGGAGGAGTACCACCACAGGCTGCAGACGTTTGCCAGC
AACTGGAGGAAGATAAACGCCCACAACAATGGGAACCACACATTTAAAATGGCACTGAAC
CAATTTTCAGACATGAGCTTTGCTGAAATAAAACACAAGTATCTCTGGTCAGAGCCTCAG
AATTGCTCAGCCACCAAAAGTAACTACCTTCGAGGTACTGGTCCCTACCCACCTTCCGTG
GACTGGCGGAAAAAAGGAAATTTTGTCTCACCTGTGAAAAATCAGGGTGCCTGCGGCAGT
TGCTGGACTTTCTCCACCACTGGGGCCCTGGAGTCTGCGATCGCCATCGCAACCGGAAAG
ATGCTGTCCTTGGCGGAACAGCAGCTGGTGGACTGCGCCCAGGACTTCAATAATCACGGC
TGCCAAGGGGGTCTCCCCAGCCAGGCTTTCGAGTATATCCTGTACAACAAGGGGATCATG
GGTGAAGACACCTACCCCTACCAGGGCAAGGATGGTTATTGCAAGTTCCAACCTGGAAAG
GCCATCGGCTTTGTCAAGGATGTAGCCAACATCACAATCTATGACGAGGAAGCGATGGTG
GAGGCTGTGGCCCTCTACAACCCTGTGAGCTTTGCCTTTGAGGTGACTCAGGACTTCATG
ATGTATAGAACGGGCATCTACTCCAGTACTTCCTGCCATAAAACTCCAGATAAAGTAAAC
CATGCAGTACTGGCTGTTGGGTATGGAGAAAAAAATGGGATCCCTTACTGGATCGTGAAA
AACTCTTGGGGTCCCCAGTGGGGAATGAACGGGTACTTCCTCATCGAGCGCGGAAAGAAC
ATGTGTGGCCTGGCTGCCTGCGCCTCCTACCCCATCCCTCTGGTGTGA
Chromosome Location
15
Locus
15q24-q25
External Identifiers
ResourceLink
UniProtKB IDP09668
UniProtKB Entry NameCATH_HUMAN
GenBank Protein ID29708
GenBank Gene IDX07549
HGNC IDHGNC:2535
General References
  1. Fuchs R, Gassen HG: Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase. Nucleic Acids Res. 1989 Nov 25;17(22):9471. [Article]
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  6. Fuchs R, Machleidt W, Gassen HG: Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H. Biol Chem Hoppe Seyler. 1988 Jun;369(6):469-75. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03120p-Toluenesulfonic acidexperimentalunknownDetails
DB02140N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-SuccinamideexperimentalunknownDetails
DB04126N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-ButaneexperimentalunknownDetails
DB08526CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONEexperimentalunknownDetails