Methionine aminopeptidase
Details
- Name
- Methionine aminopeptidase
- Synonyms
- 3.4.11.18
- MAP
- Peptidase M
- Gene Name
- map
- Organism
- Staphylococcus aureus (strain MW2)
- Amino acid sequence
>lcl|BSEQ0010919|Methionine aminopeptidase MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDE NFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQ KVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAH VLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTK DGPILTTKIEEE
- Number of residues
- 252
- Molecular Weight
- 27502.085
- Theoretical pI
- 4.94
- GO Classification
- Functionsmetal ion binding / metalloaminopeptidase activityProcessesprotein initiator methionine removal
- General Function
- Metalloaminopeptidase activity
- Specific Function
- Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
- Pfam Domain Function
- Peptidase_M24 (PF00557)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0002619|759 bp CTATTCTTCTTCAATTTTTGTCGTTAAAATCGGACCATCCTTAGTCACGATAACCGTATG CTCAATTTGAGCAACAAAACTTTTATCGCTCGTTTCAAAAGCCCATTCATTTTTACCTTC TGTAACAAATGATGCATTTGATGAGATAAACGGTTCAATAGCTAATACCATACCTTCAGT TAATAATGTTTTGTCTTTTGGATCAAAGTAATTAAGTACATGTGCTGGTGCTTCATGTAA TGATAAACCAACACCATGACCTGTTAAGTTTTTAATGACTTTCAAATCATTTTGTCTAGC TGTATTATGCACCGCTTTACCAATGTTACTTAACTTAGTACCCGGTTTTACTTTTGCAAT TGCATTCTCAAATGCCATCGTTGCTACGTCACATACTTTTTGTTTCATTGGATCATCTGA TTCTCCAACGACAAATGAAATGCCTGTATCTGCATAATAGCCATTCTTCAAAGCCGATAC ATCAATATTTACTAAATCTCCTTCACGAATGACACGCTTACTTGGAATCCCATGTGCCAC CTCTTCATTGACACTAATACACGTTTGACCAGGAAAATTTTCATCATGAATTGGCGCAGA AATAGCACCGTATTCTTCAAATAACTCTTTCGCAATATTATCAAGCTCTTTCGTAGTGAT ACCTGGTTTGGTTGCAGCTTGCATTGTATTGCGCACTTTAGCGCATATGTATCCAATTTC TTTTAACGCTTGTAATTCTTCTTCTGTTTTTACAATCAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A079 UniProtKB Entry Name MAP1_STAAW GenBank Protein ID 21204998 GenBank Gene ID BA000033 - General References
- Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K: Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002 May 25;359(9320):1819-27. [Article]