Naphthalene 1,2-dioxygenase subunit alpha

Details

Name
Naphthalene 1,2-dioxygenase subunit alpha
Synonyms
  • 1.14.12.12
  • nahA3
  • nahAC
  • Naphthalene 1,2-dioxygenase ISP alpha
  • ndoC2
Gene Name
ndoB
Organism
Pseudomonas putida
Amino acid sequence
>lcl|BSEQ0017386|Naphthalene 1,2-dioxygenase subunit alpha
MNYNNKILVSESGLSQKHLIHGDEELFQHELKTIFARNWLFLTHDSLIPAPGDYVTAKMG
IDEVIVSRQNDGSIRAFLNVCRHRGKTLVSVEAGNAKGFVCSYHGWGFGSNGELQSVPFE
KDLYGESLNKKCLGLKEVARVESFHGFIYGCFDQEAPPLMDYLGDAAWYLEPMFKHSGGL
ELVGPPGKVVIKANWKAPAENFVGDAYHVGWTHASSLRSGESIFSSLAGNAALPPEGAGL
QMTSKYGSGMGVLWDGYSGVHSADLVPELMAFGGAKQERLNKEIGDVRARIYRSHLNCTV
FPNNSMLTCSGVFKVWNPIDANTTEVWTYAIVEKDMPEDLKRRLADSVQRTFGPAGFWES
DDNDNMETASQNGKKYQSRDSDLLSNLGFGEDVYGDAVYPGVVGKSAIGETSYRGFYRAY
QAHVSSSNWAEFEHASSTWHTELTKTTDR
Number of residues
449
Molecular Weight
49607.19
Theoretical pI
5.86
GO Classification
Functions
2 iron, 2 sulfur cluster binding / iron ion binding / naphthalene 1,2-dioxygenase activity
Processes
aromatic compound catabolic process
General Function
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-naphthalene dihydrodiol.
Specific Function
2 iron, 2 sulfur cluster binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017387|PG:1343187 NAHAC, PDTG1P19; PSEUDOMONAS PUTIDA NCIB 9816-4 PLASMID PDTG1; NAPHTHALENE 1,2-DIOXYGENASE IRON SULFUR PROTEIN COMPONENT LARGE SUBUNIT; K14579 NAPHTHALENE 1,2-DIOXYGENASE SUBUNIT ALPHA [EC:1.14.12.12] (N)
ATGAATTACAATAATAAAATCTTGGTAAGTGAATCTGGTCTGAGCCAAAAGCACCTGATT
CATGGCGATGAAGAACTTTTCCAACATGAACTGAAAACCATTTTTGCGCGGAACTGGCTT
TTTCTCACTCATGATAGCCTGATTCCTGCCCCCGGCGACTATGTTACCGCAAAAATGGGG
ATTGACGAGGTCATCGTCTCCCGGCAGAACGACGGTTCGATTCGTGCTTTTCTGAACGTT
TGCCGGCATCGTGGCAAGACGCTGGTGAGCGTGGAAGCCGGCAATGCCAAAGGTTTTGTT
TGCAGCTATCACGGCTGGGGCTTCGGCTCCAACGGTGAACTGCAGAGCGTTCCATTTGAA
AAAGATCTGTACGGCGAGTCGCTCAATAAAAAATGTCTGGGGTTGAAAGAAGTCGCTCGC
GTGGAGAGCTTCCATGGCTTCATCTACGGTTGCTTCGACCAGGAGGCCCCTCCTCTTATG
GACTATCTGGGTGACGCTGCTTGGTACCTGGAACCTATGTTCAAGCATTCCGGCGGTTTA
GAACTGGTCGGTCCTCCAGGCAAGGTTGTGATCAAGGCCAACTGGAAGGCACCCGCGGAA
AACTTTGTGGGAGATGCATACCACGTGGGTTGGACGCACGCGTCTTCGCTTCGCTCGGGG
GAGTCTATCTTCTCGTCGCTCGCTGGCAATGCGGCGCTACCACCTGAAGGCGCAGGCTTG
CAAATGACCTCCAAATACGGCAGCGGCATGGGTGTGTTGTGGGACGGATATTCAGGTGTG
CATAGCGCAGACTTGGTTCCGGAATTGATGGCATTCGGAGGCGCAAAGCAGGAAAGGCTG
AACAAAGAAATTGGCGATGTTCGCGCTCGGATTTATCGCAGCCACCTCAACTGCACCGTT
TTCCCGAACAACAGCATGCTGACCTGCTCGGGTGTTTTCAAAGTATGGAACCCGATCGAC
GCAAACACCACCGAGGTCTGGACCTACGCCATTGTCGAAAAAGACATGCCTGAGGATCTC
AAGCGCCGCTTGGCCGACTCTGTTCAGCGAACGTTCGGGCCTGCTGGCTTCTGGGAAAGC
GACGACAATGACAATATGGAAACAGCTTCGCAAAACGGCAAGAAATATCAATCAAGAGAT
AGTGATCTGCTTTCAAACCTTGGTTTCGGTGAGGACGTATACGGCGACGCGGTCTATCCA
GGCGTCGTCGGCAAATCGGCGATCGGCGAGACCAGTTATCGTGGTTTCTACCGGGCTTAC
CAGGCACACGTCAGCAGCTCCAACTGGGCTGAGTTCGAGCATGCCTCTAGTACTTGGCAT
ACTGAACTTACGAAGACTACTGATCGCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A110
UniProtKB Entry NameNDOB_PSEPU
GenBank Protein ID151393
GenBank Gene IDM23914
General References
  1. Kurkela S, Lehvaslaiho H, Palva ET, Teeri TH: Cloning, nucleotide sequence and characterization of genes encoding naphthalene dioxygenase of Pseudomonas putida strain NCIB9816. Gene. 1988 Dec 20;73(2):355-62. [Article]
  2. Parales JV, Kumar A, Parales RE, Gibson DT: Cloning and sequencing of the genes encoding 2-nitrotoluene dioxygenase from Pseudomonas sp. JS42. Gene. 1996 Nov 28;181(1-2):57-61. [Article]
  3. Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ: Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4. Gene. 1993 May 15;127(1):31-7. [Article]
  4. Kauppi B, Lee K, Carredano E, Parales RE, Gibson DT, Eklund H, Ramaswamy S: Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. Structure. 1998 May 15;6(5):571-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08264(1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthaleneexperimentalunknownDetails