Carboxymethylenebutenolidase

Details

Name
Carboxymethylenebutenolidase
Synonyms
  • 3.1.1.45
  • Dienelactone hydrolase
  • DLH
Gene Name
clcD
Organism
Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13)
Amino acid sequence
>lcl|BSEQ0010906|Carboxymethylenebutenolidase
MLTEGISIQSYDGHTFGALVGSPAKAPAPVIVIAQEIFGVNAFMRETVSWLVDQGYAAVC
PDLYARQAPGTALDPQDERQREQAYKLWQAFDMEAGVGDLEAAIRYARHQPYSNGKVGLV
GYCLGGALAFLVAAKGYVDRAVGYYGVGLEKQLKKVPEVKHPALFHMGGQDHFVPAPSRQ
LITEGFGANPLLQVHWYEEAGHSFARTSSSGYVASAAALANERRLDFLAPLQSKKP
Number of residues
236
Molecular Weight
25554.855
Theoretical pI
6.88
GO Classification
Functions
carboxymethylenebutenolidase activity
Processes
aromatic compound catabolic process
General Function
Carboxymethylenebutenolidase activity
Specific Function
Ring cleavage of cyclic ester dienelactone to produce maleylacetate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0002580|711 bp
ATGTTGACTGAAGGGATATCGATTCAATCGTATGACGGGCATACATTCGGCGCGCTCGTG
GGCTCGCCGGCCAAAGCGCCCGCTCCCGTGATTGTGATCGCTCAAGAAATATTTGGTGTG
AACGCGTTCATGCGAGAAACGGTGTCATGGCTGGTCGACCAGGGGTATGCGGCAGTTTGC
CCTGATCTGTACGCGCGCCAGGCGCCAGGTACAGCACTCGATCCGCAGGATGAGCGCCAG
AGAGAGCAAGCCTACAAGCTCTGGCAGGCCTTCGACATGGAGGCCGGCGTGGGCGATCTG
GAGGCTGCTATCCGCTATGCGCGACACCAACCCTACAGCAACGGCAAGGTGGGATTGGTG
GGGTATTGCCTGGGCGGTGCGCTTGCCTTTCTAGTGGCCGCCAAAGGATACGTGGATCGC
GCCGTAGGCTACTACGGTGTTGGACTGGAGAAGCAGCTCAAGAAGGTCCCGGAAGTCAAG
CATCCGGCGTTGTTTCACATGGGCGGCCAAGACCACTTCGTGCCCGCGCCAAGCCGCCAG
CTGATTACTGAAGGCTTCGGTGCCAATCCATTGCTGCAAGTGCACTGGTACGAAGAGGCC
GGACACTCGTTCGCCAGGACGAGCAGTTCGGGCTATGTGGCGAGTGCCGCGGCGTTGGCC
AACGAACGTAGACTGGATTTCCTGGCGCCCTTGCAGAGCAAGAAGCCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A115
UniProtKB Entry NameCLCD_PSEKB
GenBank Protein ID151137
GenBank Gene IDM15201
General References
  1. Frantz B, Ngai KL, Chatterjee DK, Ornston LN, Chakrabarty AM: Nucleotide sequence and expression of clcD, a plasmid-borne dienelactone hydrolase gene from Pseudomonas sp. strain B13. J Bacteriol. 1987 Feb;169(2):704-9. [Article]
  2. Kasberg T, Seibert V, Schlomann M, Reineke W: Cloning, characterization, and sequence analysis of the clcE gene encoding the maleylacetate reductase of Pseudomonas sp. strain B13. J Bacteriol. 1997 Jun;179(11):3801-3. [Article]
  3. Pathak D, Ngai KL, Ollis D: X-ray crystallographic structure of dienelactone hydrolase at 2.8 A. J Mol Biol. 1988 Nov 20;204(2):435-45. [Article]
  4. Pathak D, Ollis D: Refined structure of dienelactone hydrolase at 1.8 A. J Mol Biol. 1990 Jul 20;214(2):497-525. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01973O-Benzylsulfonyl-SerineexperimentalunknownDetails
DB021533-sulfino-L-alanineexperimentalunknownDetails