Neocarzinostatin

Details

Name
Neocarzinostatin
Synonyms
  • Mitomalcin
  • MMC
  • NCS
Gene Name
ncsA
Organism
Streptomyces malayensis
Amino acid sequence
>lcl|BSEQ0011321|Neocarzinostatin
AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYDVGQCAWVDTGVLACNPADFSSVTADAN
GSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFN
Number of residues
113
Molecular Weight
11096.03
Theoretical pI
3.83
GO Classification
Functions
DNA binding
Processes
defense response to bacterium
General Function
Dna binding
Specific Function
NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A3S0
UniProtKB Entry NameNCZS_STRML
General References
  1. Gao XL, Burkhart W: Two- and three-dimensional proton NMR studies of apo-neocarzinostatin. Biochemistry. 1991 Aug 6;30(31):7730-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04408Ncs-ChromophoreexperimentalunknownDetails