Aminoglycoside 3'-phosphotransferase
Details
- Name
- Aminoglycoside 3'-phosphotransferase
- Synonyms
- 2.7.1.95
- APH(3')III
- Kanamycin kinase, type III
- Neomycin-kanamycin phosphotransferase type III
- Gene Name
- aphA
- Organism
- Enterococcus faecalis
- Amino acid sequence
>lcl|BSEQ0021981|Aminoglycoside 3'-phosphotransferase MAKMRISPELKKLIEKYRCVKDTEGMSPAKVYKLVGENENLYLKMTDSRYKGTTYDVERE KDMMLWLEGKLPVPKVLHFERHDGWSNLLMSEADGVLCSEEYEDEQSPEKIIELYAECIR LFHSIDISDCPYTNSLDSRLAELDYLLNNDLADVDCENWEEDTPFKDPRELYDFLKTEKP EEELVFSHGDLGDSNIFVKDGKVSGFIDLGRSGRADKWYDIAFCVRSIREDIGEEQYVEL FFDLLGIKPDWEKIKYYILLDELF
- Number of residues
- 264
- Molecular Weight
- 30973.715
- Theoretical pI
- 4.27
- GO Classification
- FunctionsATP binding / kanamycin kinase activityProcessesresponse to antibiotic
- General Function
- Kanamycin kinase activity
- Specific Function
- Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.
- Pfam Domain Function
- APH (PF01636)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003680|795 bp ATGGCTAAAATGAGAATATCACCGGAATTGAAAAAACTGATCGAAAAATACCGCTGCGTA AAAGATACGGAAGGAATGTCTCCTGCTAAGGTATATAAGCTGGTGGGAGAAAATGAAAAC CTATATTTAAAAATGACGGACAGCCGGTATAAAGGGACCACCTATGATGTGGAACGGGAA AAGGACATGATGCTATGGCTGGAAGGAAAGCTGCCTGTTCCAAAGGTCCTGCACTTTGAA CGGCATGATGGCTGGAGCAATCTGCTCATGAGTGAGGCCGATGGCGTCCTTTGCTCGGAA GAGTATGAAGATGAACAAAGCCCTGAAAAGATTATCGAGCTGTATGCGGAGTGCATCAGG CTCTTTCACTCCATCGACATATCGGATTGTCCCTATACGAATAGCTTAGACAGCCGCTTA GCCGAATTGGATTACTTACTGAATAACGATCTGGCCGATGTGGATTGCGAAAACTGGGAA GAAGACACTCCATTTAAAGATCCGCGCGAGCTGTATGATTTTTTAAAGACGGAAAAGCCC GAAGAGGAACTTGTCTTTTCCCACGGCGACCTGGGAGACAGCAACATCTTTGTGAAAGAT GGCAAAGTAAGTGGCTTTATTGATCTTGGGAGAAGCGGCAGGGCGGACAAGTGGTATGAC ATTGCCTTCTGCGTCCGGTCGATCAGGGAGGATATCGGGGAAGAACAGTATGTCGAGCTA TTTTTTGACTTACTGGGGATCAAGCCTGATTGGGAGAAAATAAAATATTATATTTTACTG GATGAATTGTTTTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A3Y5 UniProtKB Entry Name KKA3_ENTFL GenBank Protein ID 47034 GenBank Gene ID V01547 - General References
- Trieu-Cuot P, Courvalin P: Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III. Gene. 1983 Sep;23(3):331-41. [Article]