ATP-dependent protease ATPase subunit HslU
Details
- Name
- ATP-dependent protease ATPase subunit HslU
- Synonyms
- Heat shock protein HslU
- htpI
- Unfoldase HslU
- Gene Name
- hslU
- Organism
- Shigella flexneri
- Amino acid sequence
>lcl|BSEQ0012296|ATP-dependent protease ATPase subunit HslU MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTG VGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNR YRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAA PMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELK QDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTD HILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMA TEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITI DADYVSKHLDALVADEDLSRFIL
- Number of residues
- 443
- Molecular Weight
- 49593.33
- Theoretical pI
- 5.0
- GO Classification
- FunctionsATP binding / ATPase activity / peptidase activity, acting on L-amino acid peptidesProcessesprotein unfoldingComponentsHslUV protease complex
- General Function
- Peptidase activity, acting on l-amino acid peptides
- Specific Function
- ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012297|ATP-dependent protease ATPase subunit HslU (hslU) ATGTCTGAAATGACCCCACGCGAAATCGTCAGCGAACTGGATAAGCACATCATCGGCCAG GACAACGCCAAGCGTTCTGTGGCGATTGCTCTGCGTAACCGCTGGCGTCGCATGCAGCTC AACGAAGAGCTGCGCCATGAAGTGACCCCGAAAAATATCCTGATGATCGGCCCGACCGGT GTCGGTAAAACTGAAATCGCCCGTCGTCTGGCTAAGCTGGCGAATGCGCCGTTCATCAAA GTTGAAGCGACCAAATTTACCGAAGTGGGCTACGTCGGTAAGGAAGTTGATTCTATTATT CGCGATCTGACCGATGCCGCCGTGAAAATGGTACGCGTCCAGGCTATCGAGAAAAACCGT TATCGCGCTGAAGAACTGGCAGAAGAACGTATTCTCGACGTGCTGATCCCACCTGCTAAA AACAACTGGGGACAGACTGAACAGCAGCAGGAACCTTCCGCTGCTCGTCAGGCATTCCGC AAAAAACTGCGTGAAGGCCAGCTTGATGACAAAGAAATCGAGATCGATCTTGCCGCAGCA CCGATGGGCGTTGAAATTATGGCTCCTCCGGGCATGGAAGAGATGACCAGCCAGCTGCAG TCCATGTTCCAGAACCTGGGCGGCCAGAAGCAAAAAGCGCGTAAGCTGAAAATCAAAGAC GCCATGAAGCTGCTGATTGAAGAAGAAGCGGCGAAACTGGTGAACCCGGAAGAGCTGAAG CAAGACGCTATCGACGCTGTTGAGCAGCACGGGATCGTGTTTATCGACGAAATCGACAAA ATCTGTAAGCGCGGCGAGTCTTCCGGTCCGGATGTTTCTCGTGAAGGCGTTCAGCGTGAC CTGCTGCCGCTGGTAGAAGGTTGCACCGTTTCCACCAAACACGGGATGGTCAAAACTGAC CACATTCTGTTTATCGCTTCTGGCGCGTTCCAGATTGCGAAACCGTCTGACCTGATCCCG GAACTGCAAGGTCGGCTGCCAATCCGCGTTGAACTGCAGGCACTGACCACCAGCGACTTC GAGCGTATTCTGACCGAGCCGAATGCCTCTATCACCGTGCAGTACAAAGCACTGATGGCG ACTGAAGGCGTAAATATCGAGTTTACCGACTCCGGTATTAAACGCATCGCGGAAGCGGCA TGGCAGGTGAACGAATCTACCGAAAACATCGGTGCTCGTCGTTTACACACTGTTCTGGAG CGTTTAATGGAAGAGATTTCCTACGACGCCAGCGATTTAAGCGGTCAAAATATCACTATT GACGCAGATTATGTGAGCAAACATCTGGATGCGTTGGTGGCAGATGAAGATCTGAGCCGT TTTATCCTATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A6H7 UniProtKB Entry Name HSLU_SHIFL GenBank Gene ID AE005674 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]