3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Details

Name
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
Synonyms
  • 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
  • 4.2.1.59
  • Beta-hydroxydecanoyl thioester dehydrase
  • Trans-2-decenoyl-[acyl-carrier-protein] isomerase
Gene Name
fabA
Organism
Shigella flexneri
Amino acid sequence
>lcl|BSEQ0011309|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELD
INPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLP
TAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF
Number of residues
172
Molecular Weight
18968.945
Theoretical pI
6.52
GO Classification
Functions
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity / 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity / trans-2-decenoyl-acyl-carrier-protein isomerase activity
Processes
fatty acid biosynthetic process
Components
cytoplasm
General Function
Trans-2-decenoyl-acyl-carrier-protein isomerase activity
Specific Function
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011310|3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (fabA)
ATGGTAGATAAACGCGAATCCTATACAAAAGAAGACCTTCTTGCCTCTGGTCGCGGTGAA
CTGTTTGGCGCTAAAGGCCCGCAATTGCCAGCACCGAACATGCTGATGATGGACCGTGTG
GTCAAAATGACCGAAACGGGTGGTAACTTCGACAAAGGGTATGTTGAAGCAGAACTGGAT
ATCAATCCGGATCTGTGGTTCTTCGGATGCCACTTTATTGGCGATCCGGTTATGCCGGGA
TGCCTGGGCCTGGACGCAATGTGGCAGCTGGTAGGGTTCTACCTCGGCTGGCTGGGCGGC
GAAGGTAAAGGCCGCGCGCTGGGCGTTGGCGAAGTGAAATTCACTGGTCAGGTACTGCCG
ACAGCGAAAAAAGTGACCTACCGTATTCACTTTAAACGCATTGTTAACCGTCGTCTGATT
ATGGGCCTGGCGGATGGCGAAGTGCTGGTTGATGGTCGTCTGATCTATACCGCCAGCGAC
CTGAAAGTCGGTCTGTTCCAGGATACGTCTGCCTTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A6Q5
UniProtKB Entry NameFABA_SHIFL
GenBank Protein ID24051235
GenBank Gene IDAE005674
General References
  1. Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
  2. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB038132-Decenoyl N-acetyl cysteamineexperimentalunknownDetails