Fumarate reductase subunit C

Details

Name
Fumarate reductase subunit C
Synonyms
  • Fumarate reductase 15 kDa hydrophobic protein
Gene Name
frdC
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0012754|Fumarate reductase subunit C
MTTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGF
VDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVA
TIVILFVALYW
Number of residues
131
Molecular Weight
15014.91
Theoretical pI
10.32
GO Classification
Functions
succinate dehydrogenase (ubiquinone) activity / succinate dehydrogenase activity
Processes
anaerobic respiration / bacterial-type flagellum assembly / bacterial-type flagellum-dependent cell motility / fermentation
Components
integral component of membrane / plasma membrane / plasma membrane fumarate reductase complex
General Function
Succinate dehydrogenase activity
Specific Function
Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.
Pfam Domain Function
Transmembrane Regions
22-49 66-90 105-128
Cellular Location
Cell inner membrane
Gene sequence
>lcl|BSEQ0012755|Fumarate reductase subunit C (frdC)
ATGACGACTAAACGTAAACCGTATGTACGGCCAATGACGTCCACCTGGTGGAAAAAATTG
CCGTTTTATCGCTTTTACATGCTGCGCGAAGGCACGGCGGTTCCGGCTGTGTGGTTCAGC
ATTGAACTGATTTTCGGGCTGTTTGCCCTGAAAAATGGCCCGGAAGCCTGGGCGGGATTC
GTCGACTTTTTACAAAACCCGGTTATCGTGATCATTAACCTGATCACTCTGGCGGCAGCT
CTGCTGCACACCAAAACCTGGTTTGAACTGGCACCGAAAGCGGCCAATATCATTGTAAAA
GACGAAAAAATGGGACCAGAGCCAATTATCAAAAGTCTCTGGGCGGTAACTGTGGTTGCC
ACCATCGTAATCCTGTTTGTTGCCCTGTACTGGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A8Q0
UniProtKB Entry NameFRDC_ECOLI
GenBank Protein ID7019629
GenBank Gene IDJ01611
General References
  1. Grundstrom T, Jaurin B: Overlap between ampC and frd operons on the Escherichia coli chromosome. Proc Natl Acad Sci U S A. 1982 Feb;79(4):1111-5. [Article]
  2. Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [Article]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  4. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  5. Yi X, Mroczko M, Manoj KM, Wang X, Hager LP: Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12412-7. [Article]
  6. Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G: Global topology analysis of the Escherichia coli inner membrane proteome. Science. 2005 May 27;308(5726):1321-3. [Article]
  7. Iverson TM, Luna-Chavez C, Cecchini G, Rees DC: Structure of the Escherichia coli fumarate reductase respiratory complex. Science. 1999 Jun 18;284(5422):1961-6. [Article]
  8. Iverson TM, Luna-Chavez C, Croal LR, Cecchini G, Rees DC: Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site. J Biol Chem. 2002 May 3;277(18):16124-30. Epub 2002 Feb 15. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB074902-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOLexperimentalunknownDetails
DB079182-heptyl-4-hydroxyquinoline N-oxideexperimentalunknownDetails