Pepsin A-5
Details
- Name
- Pepsin A-5
- Synonyms
- 3.4.23.1
- Pepsinogen-5
- Gene Name
- PGA5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052100|Pepsin A-5 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGS LNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGEL WILGDVFIRQYFTVFDRANNQVGLAPVA
- Number of residues
- 388
- Molecular Weight
- 41992.845
- Theoretical pI
- Not Available
- GO Classification
- Functionsaspartic-type endopeptidase activityProcessescellular protein metabolic process / digestion / protein catabolic process / proteolysisComponentsextracellular exosome / multivesicular body lumen
- General Function
- Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
- Specific Function
- Aspartic-type endopeptidase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052101|Pepsin A-5 (PGA5) ATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCGCTCTCTGAGTGCATCATGTACAAGGTC CCCCTCATCAGAAAGAAGTCCTTGAGGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGAC TTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGGAGGCTCCC ACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAGTACTTCGGCACTATC GGCATCGGAACTCCTGCCCAGGATTTCACCGTCGTCTTTGACACCGGCTCCTCCAACCTG TGGGTGCCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAACCACAACCGCTTCAACCCT GAGGATTCTTCCACCTACCAGTCCACCAGCGAGACAGTCTCCATCACCTACGGCACCGGC AGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAAT CAGATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGAT GGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCCGGGGCCACACCCGTCTTTGAC AACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGAT GACAAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGT CTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAGATCACCGTGGACAGCATCACC ATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACC TCTCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGC GAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCCATCAGCAGCCTGCCCGACATC GTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGC GAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTT TGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAAC CAGGTCGGCCTGGCCCCTGTGGCTTAA
- Chromosome Location
- 11
- Locus
- 11q12.2
- External Identifiers
Resource Link UniProtKB ID P0DJD9 UniProtKB Entry Name PEPA5_HUMAN HGNC ID HGNC:8887 - General References
- Evers MP, Zelle B, Bebelman JP, van Beusechem V, Kraakman L, Hoffer MJ, Pronk JC, Mager WH, Planta RJ, Eriksson AW, et al.: Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. Genomics. 1989 Apr;4(3):232-9. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
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- Ichihara Y, Sogawa K, Takahashi K: Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences. J Biochem. 1985 Aug;98(2):483-92. doi: 10.1093/oxfordjournals.jbchem.a135303. [Article]
- Athauda SB, Tanji M, Kageyama T, Takahashi K: A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. J Biochem. 1989 Nov;106(5):920-7. doi: 10.1093/oxfordjournals.jbchem.a122952. [Article]
- Foltmann B: Activation of human pepsinogens. FEBS Lett. 1988 Dec 5;241(1-2):69-72. doi: 10.1016/0014-5793(88)81033-0. [Article]
- Huang WY, Tang J: Carboxyl-terminal sequence of human gastricsin and pepsin. J Biol Chem. 1970 May 10;245(9):2189-93. [Article]
- Sogawa K, Fujii-Kuriyama Y, Mizukami Y, Ichihara Y, Takahashi K: Primary structure of human pepsinogen gene. J Biol Chem. 1983 Apr 25;258(8):5306-11. [Article]
- Fujinaga M, Chernaia MM, Tarasova NI, Mosimann SC, James MN: Crystal structure of human pepsin and its complex with pepstatin. Protein Sci. 1995 May;4(5):960-72. doi: 10.1002/pro.5560040516. [Article]