Pepsin A-5

Details

Name
Pepsin A-5
Synonyms
  • 3.4.23.1
  • Pepsinogen-5
Gene Name
PGA5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052100|Pepsin A-5
MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP
TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGS
LNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGEL
WILGDVFIRQYFTVFDRANNQVGLAPVA
Number of residues
388
Molecular Weight
41992.845
Theoretical pI
Not Available
GO Classification
Functions
aspartic-type endopeptidase activity
Processes
cellular protein metabolic process / digestion / protein catabolic process / proteolysis
Components
extracellular exosome / multivesicular body lumen
General Function
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Specific Function
Aspartic-type endopeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0052101|Pepsin A-5 (PGA5)
ATGAAGTGGCTGCTGCTGCTGGGTCTGGTGGCGCTCTCTGAGTGCATCATGTACAAGGTC
CCCCTCATCAGAAAGAAGTCCTTGAGGCGCACCCTGTCCGAGCGTGGCCTGCTGAAGGAC
TTCCTGAAGAAGCACAACCTCAACCCAGCCAGAAAGTACTTCCCCCAGTGGGAGGCTCCC
ACCCTGGTAGATGAACAGCCCCTGGAGAACTACCTGGATATGGAGTACTTCGGCACTATC
GGCATCGGAACTCCTGCCCAGGATTTCACCGTCGTCTTTGACACCGGCTCCTCCAACCTG
TGGGTGCCCTCAGTCTACTGCTCCAGTCTTGCCTGCACCAACCACAACCGCTTCAACCCT
GAGGATTCTTCCACCTACCAGTCCACCAGCGAGACAGTCTCCATCACCTACGGCACCGGC
AGCATGACAGGCATCCTCGGATACGACACTGTCCAGGTTGGAGGCATCTCTGACACCAAT
CAGATCTTCGGCCTGAGCGAGACGGAACCTGGCTCCTTCCTGTATTATGCTCCCTTCGAT
GGCATCCTGGGGCTGGCCTACCCCAGCATTTCCTCCTCCGGGGCCACACCCGTCTTTGAC
AACATCTGGAACCAGGGCCTGGTTTCTCAGGACCTCTTCTCTGTCTACCTCAGCGCCGAT
GACAAGAGTGGCAGCGTGGTGATCTTTGGTGGCATTGACTCTTCTTACTACACTGGAAGT
CTGAACTGGGTGCCTGTTACCGTCGAGGGTTACTGGCAGATCACCGTGGACAGCATCACC
ATGAACGGAGAGACCATCGCCTGTGCTGAGGGCTGCCAGGCCATTGTTGACACCGGCACC
TCTCTGCTGACCGGCCCAACCAGCCCCATTGCCAACATCCAGAGCGACATCGGAGCCAGC
GAGAACTCAGATGGCGACATGGTGGTCAGCTGCTCAGCCATCAGCAGCCTGCCCGACATC
GTCTTCACCATCAATGGAGTCCAGTACCCCGTGCCACCCAGTGCCTACATCCTGCAGAGC
GAGGGGAGCTGCATCAGTGGCTTCCAGGGCATGAACGTCCCCACCGAATCTGGAGAGCTT
TGGATCCTGGGTGATGTCTTCATCCGCCAGTACTTTACCGTCTTCGACAGGGCAAACAAC
CAGGTCGGCCTGGCCCCTGTGGCTTAA
Chromosome Location
11
Locus
11q12.2
External Identifiers
ResourceLink
UniProtKB IDP0DJD9
UniProtKB Entry NamePEPA5_HUMAN
HGNC IDHGNC:8887
General References
  1. Evers MP, Zelle B, Bebelman JP, van Beusechem V, Kraakman L, Hoffer MJ, Pronk JC, Mager WH, Planta RJ, Eriksson AW, et al.: Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. Genomics. 1989 Apr;4(3):232-9. [Article]
  2. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Ichihara Y, Sogawa K, Takahashi K: Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences. J Biochem. 1985 Aug;98(2):483-92. doi: 10.1093/oxfordjournals.jbchem.a135303. [Article]
  5. Athauda SB, Tanji M, Kageyama T, Takahashi K: A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins. J Biochem. 1989 Nov;106(5):920-7. doi: 10.1093/oxfordjournals.jbchem.a122952. [Article]
  6. Foltmann B: Activation of human pepsinogens. FEBS Lett. 1988 Dec 5;241(1-2):69-72. doi: 10.1016/0014-5793(88)81033-0. [Article]
  7. Huang WY, Tang J: Carboxyl-terminal sequence of human gastricsin and pepsin. J Biol Chem. 1970 May 10;245(9):2189-93. [Article]
  8. Sogawa K, Fujii-Kuriyama Y, Mizukami Y, Ichihara Y, Takahashi K: Primary structure of human pepsinogen gene. J Biol Chem. 1983 Apr 25;258(8):5306-11. [Article]
  9. Fujinaga M, Chernaia MM, Tarasova NI, Mosimann SC, James MN: Crystal structure of human pepsin and its complex with pepstatin. Protein Sci. 1995 May;4(5):960-72. doi: 10.1002/pro.5560040516. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00364SucralfateapprovedyesinhibitorDetails