Adrenodoxin, mitochondrial
Details
- Name
- Adrenodoxin, mitochondrial
- Synonyms
- Adrenal ferredoxin
- ADX
- Ferredoxin-1
- Hepatoredoxin
- Gene Name
- FDX1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010215|Adrenodoxin, mitochondrial MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARAR SSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFE DHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDV GKTS
- Number of residues
- 184
- Molecular Weight
- 19392.475
- Theoretical pI
- 5.62
- GO Classification
- Functions2 iron, 2 sulfur cluster binding / electron carrier activity / iron ion bindingProcessesC21-steroid hormone biosynthetic process / cholesterol metabolic process / hormone biosynthetic process / oxidation-reduction process / small molecule metabolic process / steroid metabolic process / sterol metabolic process / xenobiotic metabolic processComponentsmitochondrial matrix / mitochondrion
- General Function
- Iron ion binding
- Specific Function
- Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
- Pfam Domain Function
- Fer2 (PF00111)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion matrix
- Gene sequence
>lcl|BSEQ0010216|Adrenodoxin, mitochondrial (FDX1) ATGGCTGCCGCTGGGGGCGCCCGGCTGCTGCGCGCCGCTTCTGCTGTCCTCGGCGGCCCG GCCGGCCGGTGGCTGCACCACGCTGGGTCCCGCGCTGGATCCAGCGGCCTGCTGAGGAAC CGGGGGCCGGGCGGGAGCGCGGAGGCGAGCCGGTCGCTGAGCGTGTCGGCGCGGGCCCGG AGCAGCTCAGAAGATAAAATAACAGTCCACTTTATAAACCGTGATGGTGAAACATTAACA ACCAAAGGAAAAGTTGGTGATTCTCTGCTAGATGTTGTGGTTGAAAATAATCTAGATATT GATGGCTTTGGTGCATGTGAGGGAACCCTGGCTTGTTCAACCTGTCACCTCATCTTTGAA GATCACATATATGAGAAGTTAGATGCAATCACTGATGAGGAGAATGACATGCTCGATCTG GCATATGGACTAACAGACAGATCACGGTTGGGCTGCCAAATCTGTTTGACAAAATCTATG GACAATATGACTGTTCGAGTGCCTGAAACAGTGGCTGATGCCAGACAATCCATTGATGTG GGCAAGACCTCCTGA
- Chromosome Location
- 11
- Locus
- 11q22
- External Identifiers
Resource Link UniProtKB ID P10109 UniProtKB Entry Name ADX_HUMAN GenBank Protein ID 557734 GenBank Gene ID M23668 GenAtlas ID FDX1 HGNC ID HGNC:3638 - General References
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