Non-secretory ribonuclease
Details
- Name
- Non-secretory ribonuclease
- Synonyms
- 3.1.27.5
- EDN
- Eosinophil-derived neurotoxin
- Ribonuclease 2
- Ribonuclease US
- RNase 2
- RNase UpI-2
- RNS2
- Gene Name
- RNASE2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0020520|Non-secretory ribonuclease MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNY QRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNI SNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
- Number of residues
- 161
- Molecular Weight
- 18354.09
- Theoretical pI
- 8.83
- GO Classification
- Functionsendonuclease activity / nucleic acid binding / ribonuclease A activity / ribonuclease activityProcesseschemotaxis / nucleic acid phosphodiester bond hydrolysis / positive regulation of protein targeting to mitochondrion / RNA catabolic process / RNA phosphodiester bond hydrolysisComponentsextracellular exosome / extracellular region / lysosome
- General Function
- Ribonuclease activity
- Specific Function
- This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
- Pfam Domain Function
- RnaseA (PF00074)
- Transmembrane Regions
- Not Available
- Cellular Location
- Lysosome
- Gene sequence
>lcl|BSEQ0020521|Non-secretory ribonuclease (RNASE2) ATGGTTCCAAAACTGTTCACTTCCCAAATTTGTCTGCTTCTTCTGTTGGGGCTTCTGGCT GTGGAGGGCTCACTCCATGTCAAACCTCCACAGTTTACCTGGGCTCAATGGTTTGAAACC CAGCACATCAATATGACCTCCCAGCAATGCACCAATGCAATGCAGGTCATTAACAATTAT CAACGGCGATGCAAAAACCAAAATACTTTCCTTCTTACAACTTTTGCTAACGTAGTTAAT GTTTGTGGTAACCCAAATATGACCTGTCCTAGTAACAAAACTCGCAAAAATTGTCACCAC AGTGGAAGCCAGGTGCCTTTAATCCACTGTAACCTCACAACTCCAAGTCCACAGAATATT TCAAACTGCAGGTATGCGCAGACACCAGCAAACATGTTCTATATAGTTGCATGTGACAAC AGAGATCAACGACGAGACCCTCCACAGTATCCGGTGGTTCCAGTTCACCTGGATAGAATC ATCTAA
- Chromosome Location
- 14
- Locus
- 14q24-q31
- External Identifiers
Resource Link UniProtKB ID P10153 UniProtKB Entry Name RNAS2_HUMAN GenBank Protein ID 181955 GenBank Gene ID M30510 GenAtlas ID RNASE2 HGNC ID HGNC:10045 - General References
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